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Cat. No.: HY-N17882A

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Hydroxysaikosaponin D

Hydroxysaikosaponin D is a hepatocytoprotective saponin found in the roots of Bupleurum scorzonerifolium WILLD. Hydroxysaikosaponin D inhibits D-galactosamine-induced cytotoxicity in primary cultured rat hepatocytes. Hydroxysaikosaponin D mitigates D-galactosamine/LPS-induced liver injury in mice. Hydroxysaikosaponin D can be used for the research of liver injury.

For research use only. We do not sell to patients.

CAS No.: 173559-75-6
Formula: C₄₂H₇₀O₁₄
Molecular Weight:799.00

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Hydroxysaikosaponin D Chemical Structure

CAS No.: 173559-75-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

In Vitro

Hydroxysaikosaponin D (1) (0.3-30 μg/mL; 44 h) exerts a significant dose-dependent protective effect against D-galactosamine-induced cytotoxicity in primary cultured rat hepatocytes, with inhibition values ranging from 6.8% to 46.5%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 173559-75-6
Molecular Weight 799.00
Formula C₄₂H₇₀O₁₄
SMILES

C[C@]12[C@]3(C([C@@]4([H])[C@@]([C@@H](C3)O)(CCC(C)(C4)C)CO)=C[C@H]([C@]1([H])[C@@]5([C@@]([C@@](C)([C@H](CC5)O[C@H]6[C@@H]([C@H]([C@H]([C@H](O6)C)O)O[C@@H]7O[C@@H]([C@H]([C@@H]([C@H]7O)O)O)CO)O)CO)([H])CC2)C)O)C
Structure Classification
- Terpenoids
- Pentacyclic Triterpenoids
Initial Source
- Plants
- Umbelliferae
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Matsuda H, et al. New hepatoprotective saponins, bupleurosides III, VI, IX, and XIII, from Chinese Bupleuri Radix: Structure-requirements for the cytoprotective activity in primary cultured rat hepatocytes. Bioorg Med Chem Lett. 1997 Sep 9;7(17):2193-2198.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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