Antileishmanial agent-45
Antileishmanial agent-45 is a C6-substituted eugenol derivative bearing a 1,2,3-triazole linker directly attached to the aromatic ring, a free phenolic hydroxyl group, and a benzyloxy substituent. Antileishmanial agent-45 retains and enhances the antileishmanial activity of its natural-product precursor eugenol. Antileishmanial agent-45 can be used for the research of leishmaniasis.
For research use only. We do not sell to patients.
- Formula: C21H23N3O4
- Molecular Weight:381.43
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All Parasite Isoforms
More
Biological Activity
Description
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Peritoneal macrophage | CC50 |
200 μM
|
Cytotoxicity against uninfected murine intraperitoneal macrophages assessed as 50% cytotoxic concentration incubated for 72 hrs.
Cytotoxicity against uninfected murine intraperitoneal macrophages assessed as 50% cytotoxic concentration incubated for 72 hrs.
|
42662206 |
In Vitro
Antileishmanial agent-45 (compound 4D) (72 h) exhibits potent in vitro activity against L. amazonensis promastigotes with an IC50 of 11.60 μM[1].
Antileishmanial agent-45 (72 h) is the most active compound against L. amazonensis amastigotes, with an IC50 of 3.98 μM[1].
Antileishmanial agent-45 (72 h) exhibits low cytotoxicity against mouse macrophages (CC50 > 200 μM) and a high selectivity index (> 50.25)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
Molecular Weight 381.43
-
Formula C21H23N3O4
-
SMILES
C=CCC1=CC(OC)=C(O)C(N2N=NC(COCC3=CC=C(OC)C=C3)=C2)=C1
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antileishmanial agent-45 Related Classifications
HY-189345 Related Classifications
Powered by Bioz
Keywords
- Antileishmanial agent-45
- Antileishmanial agent45
- Antileishmanial agent 45
- Parasite
- Drug Derivative
- leishmaniasis
- murine macrophages
- C6-substituted eugenol derivative
- L. amazonensis promastigotes
- antileishmanial activity
- L. amazonensis amastigotes
- benzyloxy substituent
- selectivity index
- 1,2,3-triazole linker
- phenolic hydroxyl group
- Inhibitor
- inhibitor
- inhibit