Isotope-Labeled Compounds
Isotope-labeled compounds are chemical substances in which some atoms in their molecules are replaced by isotope atoms. The range of stable isotope products can cover from gases to complex molecules. Isotope-labeled compounds could provide a site-specific investigation of structures, making molecules easily detectable by mass spectrometry and NMR, and maintaining the physico-chemical properties of the target molecule at the same time.
MCE isotope-labeled compounds are all stable isotope-labeled compounds and are non-radioactive labeled substances. MCE isotope-labeled compounds are unique tools for identifying and understanding biological and chemical processes. Stable isotope-labeled products are now getting more and more popular among scientists. The scope of application is gradually penetrating into various scientific fields, such as life sciences, food and medicine, agriculture, environment, geology, etc. Stable isotope-labeled compounds have a wide range of applications in the Life Science areas, such as Metabolomics, Proteomics, Clinical studies, Deuterium drugs, etc.
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Isotope-Labeled Compounds Related Products (11100)
Related Products (11100)
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Erlotinib-d8
0 ImagesCat. No.: HY-50896S3CAS No.: 1266656-97-6Synonyms: CP-358774-d8; NSC 718781-d8; OSI-774-d8Erlotinib-d8 (CP-358774-d8) is the deuterated-labeled Erlotinib (HY-50896). Erlotinib (CP-358774) is a selective, orally active EGFR tyrosine kinase inhibitor. Erlotinib also acts as a substrate and inhibitor of OATP2B1, with an IC50 of approximately 0.079 μM for inhibiting OATP2B1-mediated uptake of estrone 3-sulfate. Erlotinib blocks EGFR phosphorylation, downstream signal transduction, as well as the growth and proliferation of cancer cells. Erlotinib inhibits MMP-10-mediated renal injury, fibrotic lesions, the ERK1/2, GSK-3β and β-catenin signaling pathways, as well as the deposition of fibronectin, α-SMA, collagen and renal injury markers. Erlotinib is metabolized via CYP3A to produce the active metabolite OSI-420. Erlotinib can be used in research related to non-small cell lung cancer, gastric cancer, papillary renal cell carcinoma, EGFR inhibitor resistance and renal fibrosis.
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Octamethylcyclotetrasiloxane-d12
0 ImagesCat. No.: HY-W116007SSynonyms: Octaphenyl silsesquioxane-d12Octamethylcyclotetrasiloxane-d12 (Octaphenyl silsesquioxane-d12) is deuterium labeled Octamethylcyclotetrasiloxane.
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NS 9283-d4
0 ImagesCat. No.: HY-110168SNS 9283-d4 is the deuterated-labeled NS 9283 (HY-110168). NS 9283 (A-969933) is a α4β2 nicotinic acetylcholine receptor (α4β2 nAChR) positive allosteric modulator that preferentially targets the (α4)3 (β2)2 stoichiometric conformation. NS 9283 increases the potency of ACh-induced currents without enhancing the maximal effect of ACh. NS 9283 also enhances prefrontal glutamate release, modulates attention-related electrophysiological responses, and potentiates the antinociceptive effects associated with α4β2 nAChR agonists. NS 9283 can be used in research related to inflammatory pain, postoperative pain, osteoarthritis pain, and Parkinson's disease.
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Taurocholic acid 3-sulfate-d4 disodium
0 ImagesCat. No.: HY-131524STaurocholic acid 3-sulfate-d4 (disodium) is the deuterium labeled Taurocholic acid 3-sulfate disodium.
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15:0 Lyso PC-d5
0 ImagesCat. No.: HY-146925SCAS No.: 2342574-95-015:0 Lyso PC-d5 is deuterium labeled 15:0 Lyso PC (HY-W329357). 15:0 Lyso PC is a lysophosphatidylcholine (Lyso PC), a product of phospholipase A2 (PLA2) hydrolysis of phosphatidylcholine (PC) and is involved in cell membrane remodeling and inflammatory signaling. 15:0 Lyso PC demonstrates significant lipid metabolism disturbances in the serum of patients with ischemic heart disease (IHD) and ischemic cardiomyopathy (ICM). 15:0 Lyso PC can be used as a lipid biomarker for cardiovascular disease.
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Octrizole-d4
0 ImagesCat. No.: HY-W009160SSynonyms: UV-329-d4Octrizole-d4 (UV-329-d4) is deuterium labeled Octrizole (HY-W009160). Octrizole (UV-329) is a UV screener/stabilizer. Octrizole can prevent products from yellowing and degradation. Octrizole exhibits significant cytotoxicity to MVLN cells at concentrations higher than 50 μM and has no obvious estrogenic activity.
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N-Acetyl-S-(2-carboxyethyl)-L-cysteine-d3
0 ImagesCat. No.: HY-144407SCAS No.: 1260619-43-9N-Acetyl-S-(2-carboxyethyl)-L-cysteine-d3 is the deuterium labeled N-Acetyl-S-(2-carboxyethyl)-L-cysteine.
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4,4′-Dibromo diphenyl ether-13C12
0 ImagesCat. No.: HY-W092778SCAS No.: 488710-17-44,4′-Dibromo diphenyl ether-13C12 is 13C labeled 4,4'-Oxybis(bromobenzene).
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2-Amino-4-methoxy-6-methyl-1,3,5-triazine-d3
0 ImagesCat. No.: HY-W010319SCAS No.: 2377723-87-8Synonyms: CGA-150829-d32-Amino-4-methoxy-6-methyl-1,3,5-triazine-d3 (CGA-150829-d3) is deuterium labeled 2-Amino-4-methoxy-6-methyl-1,3,5-triazine.
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Betrixaban-dsub>4
0 ImagesCat. No.: HY-10268S1CAS No.: 2098655-55-9Synonyms: PRT054021-dsub>4Betrixaban-d4 (PRT054021-d4) is deuterium labeled Betrixaban. Betrixaban (PRT054021) is a highly potent, selective, and orally efficacious factor Xa (fXa) inhibitor with an IC50 of 1.5 nM. Betrixaban shows antithrombotic effect.
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2-Amino-2-methylpropane-1-sulfonic acid-d6
0 ImagesCat. No.: HY-W720219S2-Amino-2-methylpropane-1-sulfonic acid-d6 is deuterium-labeled 2-Amino-2-methylpropane-1-sulfonic acid (HY-W720219).
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5'-Guanylic acid-15N5,d12 dilithium
0 ImagesCat. No.: HY-N5134S4Synonyms: 5'-GMP-15N5,d12 dilithium; 5'-guanosine monophosphate-15N5,d12 dilithium5'-Guanylic acid-15N5,d12 (5'-GMP-15N5,d12 dilithium; 5'-guanosine monophosphate-15N5,d12) dilithium is deuterium and 15N labeled 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid (5'-GMP) is involved in several metabolic disorders, including the AICA-ribosiduria pathway, adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency (aprt), and the 2-hydroxyglutric aciduria pathway.
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22:0 Lyso-PC-d4
0 ImagesCat. No.: HY-144086SCAS No.: 2483831-14-522:0 Lyso-PC-d4 is the deuterium labeled 22:0 Lyso-PC.
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MCPA-d3
0 ImagesCat. No.: HY-W713900CAS No.: 2469242-78-0MCPA-d3-1 is the deuterium labeled MCPA (HY-B0859). MCPA is an orally active phenoxyacetic acid herbicide. MCPA interferes with membrane integrity, energy metabolism (decreases ATP levels), and redox balance in plant cells. MCPA increases hepatic cytochrome P-450 levels and increases aniline hydroxylase and 7-ethoxycoumarin O-deethylase activities. MCPA can be used to control broadleaf weeds.
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Ivacaftor-13C6
0 ImagesCat. No.: HY-13017S4Synonyms: VX-770-13C6Ivacaftor-13C6 (VX-770-13C6) is 13C labeled Ivacaftor. Ivacaftor (VX-770) is a potent and orally bioavailable CFTR potentiator, targeting G551D-CFTR and F508del-CFTR with EC50s of 100 nM and 25 nM, respectively.
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Epoxiconazole-d4
0 ImagesCat. No.: HY-119683S1CAS No.: 2699607-18-4Epoxiconazole-d4 is the deuterium labeled Epoxiconazole (HY-119683). Epoxiconazole, a fungicide, is a demethylation inhibitor of the Ergosterol biosynthesis pathway. Epoxiconazole exhibits strong inhibitory effects on both carbendazim-resistant and phenamacril-resistant isolates, and can be used for controlling many crop diseases.
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9-Bromo-10-(2-naphthyl)anthracene-d15
0 ImagesCat. No.: HY-W106110SCAS No.: 1312598-80-39-Bromo-10-(2-naphthyl)anthracene-d15 is the deuterium labeled 9-Bromo-10-(2-naphthyl)anthracene.
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Atomoxetine-d7
0 ImagesCat. No.: HY-107370SCAS No.: 919104-07-7Synonyms: Tomoxetine-d7; (R)-Tomoxetine-d7Atomoxetine-d7 (Tomoxetine-d7) is deuterium labeled Atomoxetine. Atomoxetine (Tomoxetine) is a selective noradrenaline reuptake inhibitor with Ki values of 5, 77 and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine (Tomoxetine) increases of DAEX and NEEX in the PFC and enhances catecholaminergic neurotransmission. Atomoxetine (Tomoxetine) is a potent Na+ channels (VGSCs) blocker. Atomoxetine (Tomoxetine) can be used for attention-deficit hyperactivity disorder (ADHD) research.
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Dorzolamide-d5
0 ImagesCat. No.: HY-B0109SCAS No.: 1227097-70-2Dorzolamide-d5 is the deuterium labeled Dorzolamide. Dorzolamide (L671152) is a potent carbonic anhydrase II inhibitor, with IC50 values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity.
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Solabegron-d8
0 ImagesCat. No.: HY-19436SCAS No.: 1250988-09-0Synonyms: GW 427353-d8Solabegron-d8 (GW 427353-d8) is deuterium labeled Solabegron. Solabegron (GW 427353) is a selective β3-adrenergic receptor agonist, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β3-AR, with an EC50 value of 22 nM. Solabegron (GW 427353) is being developed for the treatment of overactive bladder and irritable bowel syndrome.
