2098655-55-9
2098655-55-9
Chemical Structure
Betrixaban-dsub>4
Synonym(s): PRT054021-dsub>4
- CAS No.: 2098655-55-9
- Formula:C23H18D4ClN5O3
- Molecular Weight:455.93
InChIKey: XHOLNRLADUSQLD-UGWFXTGHSA-N
SMILES: N=C(N(C)C)C(C([2H])=C1[2H])=C([2H])C([2H])=C1C(NC2=CC=C(OC)C=C2C(NC(C=C3)=NC=C3Cl)=O)=O
Biological Activity: Betrixaban-d4 (PRT054021-d4) is deuterium labeled Betrixaban. Betrixaban (PRT054021) is a highly potent, selective, and orally efficacious factor Xa (fXa) inhibitor with an IC50 of 1.5 nM. Betrixaban shows antithrombotic effect[1][3].
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Betrixaban-dsub>4 | Betrixaban-d4 (PRT054021-d4) is deuterium labeled Betrixaban. Betrixaban (PRT054021) is a highly potent, selective, and orally efficacious factor Xa (fXa) inhibitor with an IC50 of 1.5 nM. Betrixaban shows antithrombotic effect. | |||||||||||||||||||||
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Betrixaban (Standard) | 96.59% | Betrixaban (Standard) is the analytical standard of Betrixaban. This product is intended for research and analytical applications. Betrixaban (PRT054021) is a highly potent, selective, and orally efficacious factor Xa (fXa) inhibitor with an IC50 of 1.5 nM. Betrixaban shows antithrombotic effect. | ||||||||||||||||||||
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Betrixaban-13C6 | Betrixaban-13C6 (PRT054021-13C6) is 13C labeled Betrixaban. Betrixaban (PRT054021) is a highly potent, selective, and orally efficacious factor Xa (fXa) inhibitor with an IC50 of 1.5 nM. Betrixaban shows antithrombotic effect. | |||||||||||||||||||||
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Betrixaban-d6 | 99.02% | Betrixaban-d6 is a deuterium labeled Betrixaban. Betrixaban is a highly potent, selective, and orally efficacious factor Xa (fXa) inhibitor. | ||||||||||||||||||||
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Betrixaban | 98.02% | Betrixaban (PRT054021) is a highly potent, selective, and orally efficacious factor Xa (fXa) inhibitor with an IC50 of 1.5 nM. Betrixaban shows antithrombotic effect. | ||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [3]. Lu G, et al. A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa. Nat Med. 2013 Apr;19(4):446-51. [Content Brief]
