2. Signaling Pathways
  3. Vitamin D Related/Nuclear Receptor
  4. Pregnane X Receptor (PXR)
  5. Pregnane X Receptor (PXR) Ligand

Pregnane X Receptor (PXR) Ligand

Pregnane X Receptor (PXR) Ligands (4):

Cat. No. Product Name Effect Purity
  • HY-N19818
    Glycybridin C
    		Ligand
    Glycybridin C is a Protein tyrosine phosphatase 1B (PTP1B) inhibitor and pregnane X receptor (PXR) ligand. Glycybridin C inhibits insulin and leptin signaling pathway negative regulation, LPS (HY-D1056)-induced NF-κB transcriptional activity. Glycybridin C forms hydrophobic and π-π stacking interactions with Met243, Phe288, Tyr306, and His407 residues of PXR. Glycybridin C can be used for the research of hepatocellular carcinoma, colorectal adenocarcinoma, breast carcinoma.
  • HY-W023836
    4-Chloro-2-(trifluoroacetyl)aniline
    		Ligand
    4-Chloro-2-(trifluoroacetyl)aniline (Compound 10), an analog of Efavirenz (HY-10572), is a Pregnane X receptor (PXR) ligand. 4-Chloro-2-(trifluoroacetyl)aniline has no PXR activation activity without induction of Cyp3a11 mRNA expression.
  • HY-169280
    PXR Ligand 2
    		Ligand
    PXR Ligand 2 (Compound 55) is the target protein ligand for PROTAC SMARCA2/4-degrader-34 (HY-169279).
  • HY-169277
    PXR Ligand 1
    		Ligand
    PXR Ligand 1 is a PXR Ligand and can be used for synthesis of SJYHJ-026 (HY-169264) PROTACs.