SHMT2 Inhibitor
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AGF347
0 ImagesCat. No.: HY-177092CAS No.: 2294820-23-6AGF347 is a one-carbon/purine biosynthesis inhibitor. AGF347 inhibits SHMT1/2 serine hydroxymethyltransferase and GARFTase/AICARFTase de novo purine formyltransferases, with target Ki values of 2.91 µM, 2.19 µM, 3.13 µM, and 3.72 µM, respectively. AGF347 depletes adenine nucleotides, inhibits mTOR/S6K1 signaling, reduces GSH/GSSG, and induces Apoptosis. AGF347 exhibits anticancer activity against lung cancer, colon cancer, pancreatic cancer, and epithelial ovarian cancer cells.
