2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. SHMT
  5. SHMT2 Isoform
  6. SHMT2 Inhibitor

SHMT2 Inhibitor

SHMT2 Inhibitor (1):

Cat. No. Product Name Effect Purity
  • HY-177092
    AGF347
    		Inhibitor
    AGF347 is a potent and multi-targeted antifolate that targets serine hydroxymethyltransferase (SHMT)2 in the mitochondria and SHMT1 in the cytosol, and inhibits de novo purine biosynthesis. AGF347 induces apoptosis, inhibits mTOR signaling, decreases GSH pools, and increases ROS. AGF347 inhibits proliferation of Cisplatin (HY-17394) sensitive and resistant epithelial ovarian cancer (EOC) cells. AGF347 exhibits antitumor efficacy in SKOV3 EOC xenograft mouse models. AGF347 can be used for ovarian cancer research.