TrxR Substrate
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Selenomethionine selenoxide
0 ImagesCat. No.: HY-210765CAS No.: 19192-78-0Synonyms: SeOMet; SeMetOSelenomethionine selenoxide (SeOMet; SeMetO) is an oxidative metabolite of selenomethionine (SeMet). Selenomethionine selenoxide can be reduced by GSH to generate oxidized glutathione (GSSG) while regenerating the parent compound SeMet. Selenomethionine selenoxide can serve as a substrate for the thioredoxin reductase (TrxR) and glutathione reductase (GSR) systems in the presence of NADPH. Selenomethionine selenoxide can also be formed by the reaction of SeMet with N-chloramines, and the reduction of this substance supports the catalytic cycle by which selenium-containing compounds scavenge myeloperoxidase-derived oxidants. Selenomethionine selenoxide can be taken up by wheat roots and is converted to selenomethionine after root uptake. Selenomethionine selenoxide can be used in metabolism-related research.
