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Cat. No.: HY-19391

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UK-240455

Name: UK-240455
Brand: MedChemExpress
SKU: HY-19391
Price: 571.00 USD
Availability: InStock
Rating: 5 (1 reviews)

UK-240455 is a potent and selective N-methyl D-aspartate (NMDA) glycine site antagonist.

For research use only. We do not sell to patients.

CAS No.: 178908-09-3
Formula: C₁₁H₁₁Cl₂N₃O₅S
Molecular Weight:368.19

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

UK-240455 Chemical Structure

CAS No.: 178908-09-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Purity & Documentation
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Biological Activity

Description

UK-240455 is a potent and selective N-methyl D-aspartate (NMDA) glycine site antagonist.

IC₅₀ & Target

NMDA Receptor

All iGluR Isoforms :

In Vivo

UK-240455 is a potent and selective N-methyl D-aspartate (NMDA) glycine site antagonist. Following i.v. administration of UK-240455 to male rats, UK-240455 has a clearance of 12 mL/min/kg and a volume of distribution of 0.4 L/kg. The plasma concentration of UK-240455 decreases with an apparent half-life of 0.4 h. Analysis of urine (0 to 24 h) for unchanged UK-240455 indicates that 57% of the dose administered is excreted unchanged in the urine. The urinary clearance of UK-240455 in the rat is therefore 7 mL/min/kg. Following oral administration of UK-240455 to male rats, the apparent elimination half-life of UK-240455 from plasma following oral administration is 1.6 h^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 178908-09-3
Molecular Weight 368.19
Formula C₁₁H₁₁Cl₂N₃O₅S
SMILES

CS(=O)(N(C1=C(Cl)C(Cl)=CC(NC2=O)=C1NC2=O)CCO)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Webster R, et al. Pharmacokinetics and disposition of a novel NMDA glycine site antagonist (UK-240,455) in rats, dogs and man. Xenobiotica. 2003 May;33(5):541-60. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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- IC₅₀ & Target
- In Vivo
Chemical Information
Purity & Documentation
References

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UK-240455

All iGluR Isoforms

Biological Activity

Description

IC50 & Target

In Vivo

Chemical Information

Purity & Documentation

References

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UK-240455 Related Classifications

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