2. Metabolic Enzyme/Protease Apoptosis
  3. Proteasome Apoptosis
  4. VR23

VR23 is a small molecule that potently inhibits the activities of trypsin-like proteasomes (IC50=1 nM), chymotrypsin-like proteasomes (IC50=50-100 nM), and caspase-like proteasomes (IC50=3 μM).

For research use only. We do not sell to patients.

VR23 Chemical Structure

VR23 Chemical Structure

CAS No. : 1624602-30-7

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Solid + Solvent
10 mM * 1 mL in DMSO
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10 mM * 1 mL in DMSO USD 61 In-stock
Solid
5 mg USD 55 In-stock
10 mg USD 95 In-stock
50 mg USD 320 In-stock
100 mg USD 550 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

VR23 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

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Description

VR23 is a small molecule that potently inhibits the activities of trypsin-like proteasomes (IC50=1 nM), chymotrypsin-like proteasomes (IC50=50-100 nM), and caspase-like proteasomes (IC50=3 μM).

IC50 & Target

IC50: 1 nM (trypsin-like proteasome), 50-100 nM (chymotrypsin-like proteasome), 3 μM (caspase-like proteasome)
In Vitro

VR23 is a novel proteasome inhibitor targeting β2 of the 20S proteasome subunit. VR23 produces a synergistic effect in killing multiple myeloma cells, including those that were resistant to PS-341. VR23 as a structurally novel proteasome inhibitor with desirable properties as an anticancer agent.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

VR23 Related Antibodies
In Vivo

VR23 shows effective antitumor and antiangiogenic activities in mice.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

477.88

Formula

C19H16ClN5O6S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=S(N1CCN(C2=CC=NC3=CC(Cl)=CC=C23)CC1)(C4=CC=C([N+]([O-])=O)C=C4[N+]([O-])=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (69.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0926 mL 10.4629 mL 20.9258 mL
5 mM 0.4185 mL 2.0926 mL 4.1852 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0926 mL 10.4629 mL 20.9258 mL 52.3144 mL
5 mM 0.4185 mL 2.0926 mL 4.1852 mL 10.4629 mL
10 mM 0.2093 mL 1.0463 mL 2.0926 mL 5.2314 mL
15 mM 0.1395 mL 0.6975 mL 1.3951 mL 3.4876 mL
20 mM 0.1046 mL 0.5231 mL 1.0463 mL 2.6157 mL
25 mM 0.0837 mL 0.4185 mL 0.8370 mL 2.0926 mL
30 mM 0.0698 mL 0.3488 mL 0.6975 mL 1.7438 mL
40 mM 0.0523 mL 0.2616 mL 0.5231 mL 1.3079 mL
50 mM 0.0419 mL 0.2093 mL 0.4185 mL 1.0463 mL
60 mM 0.0349 mL 0.1744 mL 0.3488 mL 0.8719 mL
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VR23 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VR231624602-30-7VR 23VR-23ProteasomeApoptosisInhibitorinhibitorinhibit

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