1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. nAChR
  3. (-)-(S)-B-973B

(-)-(S)-B-973B 

Cat. No.: HY-114269 Purity: 99.93% ee.: 92.97%
Handling Instructions

(-)-(S)-B-973B is a potent allosteric agonist and positive allosteric modulator of α7 nAChR, with antinociceptive activity.

For research use only. We do not sell to patients.

(-)-(S)-B-973B Chemical Structure

(-)-(S)-B-973B Chemical Structure

CAS No. : 2244989-34-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 308 In-stock
Estimated Time of Arrival: December 31
5 mg USD 280 In-stock
Estimated Time of Arrival: December 31
10 mg USD 420 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1200 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1900 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

(-)-(S)-B-973B is a potent allosteric agonist and positive allosteric modulator of α7 nAChR, with antinociceptive activity[1].

IC50 & Target

α7 nAChR[1]

Molecular Weight

452.50

Formula

C₂₄H₂₆F₂N₆O

CAS No.

2244989-34-0

SMILES

O=C(N[[email protected]](C1=NC(N2CCN(C3=NC=CC=C3)CC2)=CN=C1)C)CCC4=CC=C(F)C(F)=C4

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 67.5 mg/mL (149.17 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2099 mL 11.0497 mL 22.0994 mL
5 mM 0.4420 mL 2.2099 mL 4.4199 mL
10 mM 0.2210 mL 1.1050 mL 2.2099 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.25 mg/mL (4.97 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.25 mg/mL (4.97 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.25 mg/mL (4.97 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
(-)-(S)-B-973B
Cat. No.:
HY-114269
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