AChE/Aβ-IN-1
AChE/Aβ-IN-1 (compound 32) is a potent and orally active inhibitor of acetylcholinesterase (AChE) with an IC50 of 86 nM, as well as an antagonist of NMDA receptor (GluN1-1b/GluN2B subunit combination) with IC50 of 3.876 μM. AChE/Aβ-IN-1 also inhibits Aβ aggregation and shows good blood-brain barrier permeability and neuroprotection. AChE/Aβ-IN-1 improves cognitive and spatial memory impairment in rats model.
For research use only. We do not sell to patients.
- Formula: C20H25BrN4
- Molecular Weight:401.34
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
IC50: 86 nM (AChE), 3.876 μM (NMDA receptor, GluN1-1b/GluN2B subunit)[1]
AChE/Aβ-IN-1 (compound 32) (5-20 μM; 48 h) inhibits Aβ1-42 (10 μM) aggregation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 401.34
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Formula C20H25BrN4
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SMILES
BrC1=CC=C(C=C1)CN2C=C(N=N2)CNC34CC(C5)CC(C4)CC5C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AChE/Aβ-IN-1 Related Classifications
HY-155733 Related Classifications
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