AChE/Aβ-IN-1
AChE/Aβ-IN-1 (compound 32) is a potent and orally active inhibitor of acetylcholinesterase (AChE) with an IC50 of 86 nM, as well as an antagonist of NMDA receptor (GluN1-1b/GluN2B subunit combination) with IC50 of 3.876 μM. AChE/Aβ-IN-1 also inhibits Aβ aggregation and shows good blood-brain barrier permeability and neuroprotection. AChE/Aβ-IN-1 improves cognitive and spatial memory impairment in rats model.
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- Fòrmula: C20H25BrN4
- Peso molecular:401.34
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
IC50 & Target
IC50: 86 nM (AChE), 3.876 μM (NMDA receptor, GluN1-1b/GluN2B subunit)[1]
In Vitro
AChE/Aβ-IN-1 (compound 32) (5-20 μM; 48 h) inhibits Aβ1-42 (10 μM) aggregation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Peso molecular 401.34
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Fòrmula C20H25BrN4
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SMILES
BrC1=CC=C(C=C1)CN2C=C(N=N2)CNC34CC(C5)CC(C4)CC5C3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AChE/Aβ-IN-1 Related Classifications
HY-155733 Related Classifications
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