Acid Red 94 sodium (80%) 

Acid Red 94 sodium (80%), a synthetic fluorescein derivative, is a deep red dye primarily composed of 4,5,6,7-tetrachloro-2,4,5,7-tetraiodo fluorescein. Acid Red 94 sodium (80%) is widely used as an ophthalmic diagnostic agent to detect dry or damaged cells on the ocular surface. Acid Red 94 sodium (80%) exhibits antitumor activity and can inhibit Friend Leukemia Virus (FLV) infection through photodynamic action. Additionally, Acid Red 94 sodium (80%) can inhibit Aβ aggregation through light irradiation. Acid Red 94 sodium (80%) holds potential for use in cancer, viral infections, and neurodegenerative disease research^{[1][2][3][4][5][6]}.

Acid Red 94 sodium (80%) (300 µM, 48 h) exerts toxic effects on MCF-7 cells by inducing apoptosis^[3].
Acid Red 94 sodium (80%) (5 µM, under light irradiation, 24 h) inhibits Aβ aggregation, likely by binding to Ab42 and preventing its conformational transition^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Acid Red 94 sodium (80%) (50 µL PV-10 (10% Rose Bengal solution), IL, once a week for 14 weeks) induced tumor-specific immune responses and reduced the number of lung metastases in the B16 melanoma mouse model^[5].
Acid Red 94 sodium (80%) (7-200 µg, i.p., single dose) inhibits FLV infection via photodynamic action^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1017.64

C₂₀H₂Cl₄I₄Na₂O₅

632-69-9

Solid

Brown to red

O=C1OC2(C3=C(OC4=C2C=C(I)C(O[Na])=C4I)C(I)=C(O[Na])C(I)=C3)C5=C1C(Cl)=C(Cl)C(Cl)=C5Cl

Room temperature in continental US; may vary elsewhere.

RT, sealed storage, away from moisture and light

• [1]. Doughty MJ, et, al. Fluorescence characteristics of sodium fluorescein-rose bengal ophthalmic solution mixtures. Cont Lens Anterior Eye. 2014 Oct; 37(5): 358-62.  [Content Brief]

  [2]. Roat MI, et, al. The antiviral effects of rose bengal and fluorescein. Arch Ophthalmol. 1987 Oct; 105(10): 1415-7.  [Content Brief]

  [3]. Mousavi SH, et al. Direct toxicity of Rose Bengal in MCF-7 cell line: role of apoptosis. Food Chem Toxicol. 2009 Apr;47(4):855-9.  [Content Brief]

  [4]. Lee JS, et al. Photo-induced inhibition of Alzheimer's β-amyloid aggregation in vitro by rose bengal. Biomaterials. 2015 Jan;38:43-9.  [Content Brief]

  [5]. Toomey P, et al. Intralesional injection of rose bengal induces a systemic tumor-specific immune response in murine models of melanoma and breast cancer. PLoS One. 2013 Jul 17;8(7):e68561.  [Content Brief]

  [6]. Stevenson NR, Lenard J. Antiretroviral activities of hypericin and rose bengal: photodynamic effects on Friend leukemia virus infection of mice. Antiviral Res. 1993 Jun;21(2):119-27.  [Content Brief]