Acorbine
Acorbine is an orally active, hepatoprotective tripeptide present in the brackish-water bivalve Corbicula japonica. Hydrolysis of Acorbine yields free β-alanine and ornithine, which mediate the host defense system of Corbicula japonica in response to biological stress and changes in growth conditions. Acorbine inhibits ethanol-induced hepatocyte death and liver injury. Acorbine can be used in studies related to liver diseases.
For research use only. We do not sell to patients.
- CAS No.: 860314-33-6
- Formula: C13H27N5O4
- Molecular Weight:317.38
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Acorbine consists of two L-ornithine residues and one β-alanine residue; low-temperature treatment of Corbicula japonica induces proteolysis and increases the contents of free L-ornithine and β-alanine[1].
Acorbine (40 μM; 24 h) protects IVLmES/iPS hepatocytes differentiated from ST1 embryonic stem cells, Bruce 4 embryonic stem cells, and iPS-MEF-Ng-20D-17 induced pluripotent stem cells against ethanol-induced death, and preserves the urea-producing function of the liver[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 J (female, 6 weeks old at study start, alcohol-induced chronic liver injury model)[2]
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Dosage:9 mg/kg
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Administration:p.o.; once daily; 21 days
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Result:Completely suppressed ethanol-induced increases in serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels for at least 3 weeks during continued ethanol intake.
Eliminated ethanol-induced ballooning hepatocytes in liver tissue at study end, with only some lipid droplets present.
Chemical Information
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CAS No. 860314-33-6
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Molecular Weight 317.38
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Formula C13H27N5O4
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SMILES
NCCC[C@@H](C(O)=O)NC([C@H](CCCN)NC(CCN)=O)=O
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Sequence
βAla-Orn-Orn
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Sequence Shortening
βAla-OO
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Uchisawa H, et al. A novel ornithine-containing tripeptide isolated from the extract of the brackish-water bivalve Corbicula japonica. Biochimica et biophysica acta. 2007 May;1770(5):790-6. [Content Brief]
[2]. Tamai M, et al. Acorbine, a Corbicula japonica-derived tripeptide containing non-proteinogenic amino acids, suppresses ethanol-induced liver injury. Biochemical and biophysical research communications. 2020 Feb 12;522(3):580-584. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Acorbine Related Classifications
HY-P12115 Related Classifications
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