AlF-NOTA-c-d-VAP 

AlF-NOTA-c-d-VAP is a peptide positron emission tomography (PET) probe that used for targeted tumor imaging of GRP78. AlF-NOTA-c-d-VAP demonstrates high stability in vitro and in vivo^[1].

Micro-PET imaging, pharmacokinetic analysis, and biodistribution studies were carried out in tumor-bearing mice to evaluate the probe’s performance. AlF-NOTA-c-DVAP is radiolabeled in just 25 min with a high yield of 51%, a radiochemical purity of 99%, and molar activity within the range of 20-50 GBq/μmol. Dynamic PET imaging of AlF-NOTA-c-DVAP in tumors showed rapid uptake and sustained retention, with minimal background uptake. Biodistribution studies revealed rapid blood clearance and excretion through the kidneys following a single-compartment reversible metabolic model^[1].
In PET imaging, the T/M ratios for A549 tumors (high GRP78 expression), MDA-MB-231 tumors (medium expression), and HepG2 tumors (low expression) at 60 min postintravenous injection are 10.48%, 6.25%, and 3.15% ID/g, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1316.35

C₅₁H₈₃AlFN₁₇O₁₉S

C[C@@H](NC([C@H](NC([C@H](NC([C@@](NC([C@H](NC([C@H](N)CO)=O)CC(N)=O)=O)([H])[C@@H](O)C)=O)CCCNC(N)=N)=O)C(C)C)=O)C(N(CCC1)[C@H]1C(N[C@@H](C(O)=O)CSC(CC2=O)C(N2CCNC(C[N]34CC[N]5(CC[N](CC4)6C7)CC(O[Al]536(F)OC7=O)=O)=O)=O)=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Jiawen Huang, et al. Synthesis and Evaluation of [18F]AlF-NOTA-c-DVAP: A Novel PET Probe for Imaging GRP78 in Cancer. Mol Pharm. 2024 Mar 30.  [Content Brief]