ALLANHEELFQTGGGSC
ALLANHEELFQTGGGSC is a Glypican-3 (GPC3) targeting peptide that can be conjugated to fluorescent dyes via cysteine residues. ALLANHEELFQTGGGSC consists of a 12-amino-acid GPC3-binding peptide (ALLANHEELFQT) and a C-terminal GGGSC linker. ALLANHEELFQTGGGSC dose-dependently competes with and inhibits the binding of GPC3-targeting fluorescent probes to Hep3B hepatocellular carcinoma cells. ALLANHEELFQTGGGSC can be used for the construction of GPC3-targeted molecular probes and hepatocellular carcinoma-related research.
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- Fòrmula: C74H115N21O26S
- Peso molecular:1746.90
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Pureza y Documentación
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Help & FAQs
Actividad biológica
ALLANHEELFQTGGGSC (0-200 μM; 30 min) dose-dependently competes with and inhibits the binding of IRDye800-labeled GPC3-targeting peptide to human Hep3B hepatocellular carcinoma cells, and concentrations of 50 μM and above significantly reduce the fluorescence intensity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:nu/nu (female, 4-6 weeks old, 20-25 g, orthotopic xenograft model)[1]
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Dosage:1.5 mM, 100 μL
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Administration:i.v.; single dose
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Result:Showed significantly reduced tumor-to-background (T/B) ratio compared with ALL*-IRDye800 alone group[1].
ALL*-IRDye800 group demonstrated 2.1-fold higher mean T/B ratio than the ALL* (block) group at 1.5 h post-injection.
Peak tumor uptake of ALL*-IRDye800 occurred at 1.5 h post-injection, with clearance by approximately 24 h.
Served as an additional control to confirm that tumor uptake was mediated by specific peptide-target binding interactions rather than nonspecific fluorophore accumulation.
Chemical Information
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Peso molecular 1746.90
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Fòrmula C74H115N21O26S
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Sequence
Ala-Leu-Leu-Ala-Asn-His-Glu-Glu-Leu-Phe-Gln-Thr-Gly-Gly-Gly-Ser-Cys
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Sequence Shortening
ALLANHEELFQTGGGSC
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ALLANHEELFQTGGGSC Related Classifications
HY-P11937 Related Classifications
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