ALLANHEELFQTGGGSC
ALLANHEELFQTGGGSC is a Glypican-3 (GPC3) targeting peptide that can be conjugated to fluorescent dyes via cysteine residues. ALLANHEELFQTGGGSC consists of a 12-amino-acid GPC3-binding peptide (ALLANHEELFQT) and a C-terminal GGGSC linker. ALLANHEELFQTGGGSC dose-dependently competes with and inhibits the binding of GPC3-targeting fluorescent probes to Hep3B hepatocellular carcinoma cells. ALLANHEELFQTGGGSC can be used for the construction of GPC3-targeted molecular probes and hepatocellular carcinoma-related research.
For research use only. We do not sell to patients.
- Formula: C74H115N21O26S
- Molecular Weight:1746.90
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
In Vitro
ALLANHEELFQTGGGSC (0-200 μM; 30 min) dose-dependently competes with and inhibits the binding of IRDye800-labeled GPC3-targeting peptide to human Hep3B hepatocellular carcinoma cells, and concentrations of 50 μM and above significantly reduce the fluorescence intensity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:nu/nu (female, 4-6 weeks old, 20-25 g, orthotopic xenograft model)[1]
-
Dosage:1.5 mM, 100 μL
-
Administration:i.v.; single dose
-
Result:Showed significantly reduced tumor-to-background (T/B) ratio compared with ALL*-IRDye800 alone group[1].
ALL*-IRDye800 group demonstrated 2.1-fold higher mean T/B ratio than the ALL* (block) group at 1.5 h post-injection.
Peak tumor uptake of ALL*-IRDye800 occurred at 1.5 h post-injection, with clearance by approximately 24 h.
Served as an additional control to confirm that tumor uptake was mediated by specific peptide-target binding interactions rather than nonspecific fluorophore accumulation.
Chemical Information
-
Molecular Weight 1746.90
-
Formula C74H115N21O26S
-
Sequence
Ala-Leu-Leu-Ala-Asn-His-Glu-Glu-Leu-Phe-Gln-Thr-Gly-Gly-Gly-Ser-Cys
-
Sequence Shortening
ALLANHEELFQTGGGSC
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ALLANHEELFQTGGGSC Related Classifications
HY-P11937 Related Classifications
Powered by Bioz