Aluminum potassium sulfate
Based on 1 Customer Validation
Aluminum potassium sulfate (Potassium alum) is an egg white adjuvant. Aluminum potassium sulfate acts as a mordant to help dyes bind to tissue components, enhancing the staining effect and stability during staining. Aluminum potassium sulfate can induce allergic reactions in mice. Aluminum potassium sulfate can be used in research for bacterial and tissue staining.
For research use only. We do not sell to patients.
- Purity: 99.6%
- CAS No.: 10043-67-1
- Formula: KAl(SO4)2
- Molecular Weight:258.21
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Storage:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Aluminum potassium sulfate (4 h) irreversibly inhibits α-amylase (70% reduction), protease (51% reduction), and lipase (31% reduction) activities in midgut extracts of adult Periplaneta americana, with greater inhibitory effects observed in females than males[1].
Aluminum potassium sulfate can be used as an adjuvant of ovalbumin to induce anaphylaxis in mice.[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Formalized Vibrio anguillarum bacterin adjuvanted with 2.5% Aluminum potassium sulfate (100-200 μL; i.p.) causes minimal mortality, a significant reduction in growth, mild to moderate organ damage in rainbow trout[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Salmo gairdneri Richardson (approximately 3 cm length, mean weight 1.5 g)[3]
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Dosage:50; 100 μl (adjuvanted with 2.5% Aluminum potassium sulfate)
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Administration:i.p.
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Result:Reached 67% cumulative mortality at 48 days post-vaccination for the 50 μl adjuvanted dose.
Reached 74% cumulative mortality at 48 days post-vaccination for the 100 μl adjuvanted dose.
Achieved 231% weight increase over six weeks for the 50 μl adjuvanted dose.
Caused severe reactive peritonitis, inflammatory oedema of visceral peritoneum, macrophage infiltration and adjuvant deposition in serosa of ovary, liver, and pancreas, progressive focal degeneration of pancreatic acini, granulomata formation, fibroblast proliferation with collagen deposition, splenic and renal haemopoietic tissue depletion, occasional subcapsular hepatic necrosis, and heavy sequestration of alum into hepatocytes.
Showed no significant additional protection against Vibrio anguillarum challenge compared to non-adjuvanted vaccine.
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Animal Model:Salmo gairdneri Richardson (20 cm length, mean weight 100 g-156 g)[3]
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Dosage:100; 200 μl (adjuvanted with 2.5% Aluminum potassium sulfate)
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Administration:i.p.
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Result:Reached 5% cumulative mortality at 48 days post-vaccination for the 100 μl adjuvanted dose.
Reached 6% cumulative mortality at 48 days post-vaccination for the 200 μl adjuvanted dose.
Achieved 53% weight increase over six weeks for the 100 μl adjuvanted dose.
Achieved 26% weight increase over six weeks for the 200 μl adjuvanted dose.
Caused peritoneal oedema, macrophage infiltration, distortion of pancreatic acini, focal hepatic necrosis, severe focal necrosis of renal haemopoietic tissue, sequestration of alum into hepatocytes, pancreatic tissue fibrosis, organizing focal necrosis of liver and kidney, increased macrophage activity in peritoneal tissues, reduction in splenic white pulp, and gonad damage with fibrosed tissue contraction by one month post-injection.
Showed no significant additional protection against Vibrio anguillarum challenge compared to non-adjuvanted vaccine.
Chemical Information
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CAS No. 10043-67-1
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Appearance Solid
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Molecular Weight 258.21
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Formula KAl(SO4)2
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Color White to off-white
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SMILES
[K][Al](S(=O)(O[O])=O)S(=O)(O[O])=O
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Synonyms
Potassium alum
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
Solvent & Solubility
H2O : 2 mg/mL (7.75 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: Saline
Solubility: 5 mg/mL (19.36 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
Purity & Documentation
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Data Sheet (279 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Salama EM, et al. A Novel Use for Potassium Alum as Controlling Agent Against Periplaneta americana (Dictyoptera: Blattidae). J Econ Entomol. 2015;108(6):2620-2629. [Content Brief]
[2]. Sevki C, et al. Reduction of house-dust mite allergen concentrations in carpets by aluminium potassium sulfate dodecahydrate (alum). Allergy Asthma Proc. 2006;27(5):350-353. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.8728 mL | 19.3641 mL | 38.7282 mL | 96.8204 mL |
| 5 mM | 0.7746 mL | 3.8728 mL | 7.7456 mL | 19.3641 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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