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Cat. No.: HY-122007

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AM-0561

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

AM-0561 is a NIK inhibitor (K_i: 0.3 nM). AM-0561 decreases p52 levels.

For research use only. We do not sell to patients.

CAS No.: 1202764-63-3
Formula: C₁₈H₁₃ClN₆OS
Molecular Weight:396.85

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

AM-0561 Chemical Structure

CAS No.: 1202764-63-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

AM-0561 is a NIK inhibitor (K_i: 0.3 nM). AM-0561 decreases p52 levels^[1].

All NF-κB Isoforms :

Chemical Information

CAS No. 1202764-63-3
Molecular Weight 396.85
Formula C₁₈H₁₃ClN₆OS
SMILES

C[C@](C1=NC=CS1)(C#CC2=CN3C(C4=NC(N)=NC=C4Cl)=CN=C3C=C2)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Journal Impact Factor

NPJ Precis Oncol

Integrative profiling strategies to guide personalized therapy in mantle cell lymphoma: a pilot study. [Abstract]

2025 Nov 21;9(1):373. PMID: 41272086

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Demchenko YN, et al. Novel inhibitors are cytotoxic for myeloma cells with NFkB inducing kinase-dependent activation of NFkB. Oncotarget. 2014 Jun 30;5(12):4554-66. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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