Aminobenzenesulfonic auristatin E

Cat. No.: HY-145989: FAQs
Data Sheet Handling Instructions

Molarity Calculator

Aminobenzenesulfonic auristatin E is a agent-linker conjugate for ADC. Aminobenzenesulfonic auristatin E has potent antitumor activity by using Auristatin E (a cytotoxic tubulin modifier), linked via the ADC linker Aminobenzenesulfonic.

For research use only. We do not sell to patients.

Aminobenzenesulfonic auristatin E Chemical Structure

CAS No. : 1800462-99-0

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250 mg		Get quote
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Other In-stock Forms of Aminobenzenesulfonic auristatin E:

Aminobenzenesulfonic auristatin E TFA Aminobenzenesulfonic auristatin E-d₈

Other Forms of Aminobenzenesulfonic auristatin E:

Aminobenzenesulfonic auristatin E TFA In-stock
Aminobenzenesulfonic auristatin E-d₈ In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

Auristatin

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

753.00

Formula

C₃₇H₆₄N₆O₈S

CAS No.

1800462-99-0

SMILES

C[C@@H](C(N[S](=O)(C(C=C1)=CC=C1N)=O)=O)[C@H]([C@@](CCC2)([H])N2C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@@H](N(C)C)C(C)C)=O)=O)=O)OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 330 mg/mL (438.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3280 mL	6.6401 mL	13.2802 mL
5 mM	0.2656 mL	1.3280 mL	2.6560 mL
10 mM	0.1328 mL	0.6640 mL	1.3280 mL

View the Complete Stock Solution Preparation Table

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kevin HAMBLETT, et al. Anti-her2 biparatopic antibody-drug conjugates and methods of use. Patent WO2019173911A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.3280 mL	6.6401 mL	13.2802 mL	33.2005 mL
	5 mM	0.2656 mL	1.3280 mL	2.6560 mL	6.6401 mL
	10 mM	0.1328 mL	0.6640 mL	1.3280 mL	3.3201 mL
	15 mM	0.0885 mL	0.4427 mL	0.8853 mL	2.2134 mL
	20 mM	0.0664 mL	0.3320 mL	0.6640 mL	1.6600 mL
	25 mM	0.0531 mL	0.2656 mL	0.5312 mL	1.3280 mL
	30 mM	0.0443 mL	0.2213 mL	0.4427 mL	1.1067 mL
	40 mM	0.0332 mL	0.1660 mL	0.3320 mL	0.8300 mL
	50 mM	0.0266 mL	0.1328 mL	0.2656 mL	0.6640 mL
	60 mM	0.0221 mL	0.1107 mL	0.2213 mL	0.5533 mL
	80 mM	0.0166 mL	0.0830 mL	0.1660 mL	0.4150 mL
	100 mM	0.0133 mL	0.0664 mL	0.1328 mL	0.3320 mL