Anti-Mouse PD-1 Antibody (29F.1A12)
Based on 1 Customer Validation
Anti-Mouse PD-1 Antibody (29F.1A12) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse PD-1. Anti-Mouse PD-1 Antibody (29F.1A12) blocks the binding of PD-1 to its two ligands, PD-L1 and PD-L2. Anti-Mouse PD-1 Antibody (29F.1A12) can be used for the researches of cancer and immunology, such as CT26 tumor and pancreatic cancer.
For research use only. We do not sell to patients.
- Purity : 99.01%
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Isotype
Rat IgG2a kappa
Recommend Isotype Controls
Species Reactivity
Mouse
IC50 & Target
PD-1
In Vitro
Anti-Mouse PD-1 Antibody (29F.1A12) (10 μg/mL, 7 days) increases IFN-γ cytokine production and Ki-67 expression companied with anti-CTLA-4 in CD8+CTLA-4+PD-1+ tumor-infiltrating lymphocytes from CT26 tumor[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
Anti-Mouse PD-1 Antibody (29F.1A12) (100 μg, i.p., days 1, 3, and 5 following BRAF inhibitor) delays tumor growth and improves survival companied with BRAF inhibitor in BP tumor mice[2].
Anti-Mouse PD-1 Antibody (29F.1A12) (200 μg, i.p., at days 4, 7 and 10) offers protection against primary PDA and liver metastases companied with PRIP1 inhibitor in pancreatic cancer mice[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Pancreatic cancer mice models[3]
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Dosage:200 μg
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Administration:Intraperitoneally injection, at days 4, 7 and 10
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Result:Reduced tumor weight.
Prolonged survival of mice.
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Product Image
Application
in vivo blocking of PD-1/PD-L signaling; in vitro PD-1 neutralization; Immunohistochemistry (froze
Chemical Information
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Appearance Liquid
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Molecular Weight 150 kDa
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Color Colorless to light yellow
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SMILES
[Anti-Mouse PD-1 Antibody (29F.1A12)]
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (261 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Duraiswamy J, et al. Dual blockade of PD-1 and CTLA-4 combined with tumor vaccine effectively restores T-cell rejection function in tumors. Cancer Res. 2013 Jun 15;73(12):3591-603. [Content Brief]
[2]. Cooper ZA, et al. Response to BRAF inhibition in melanoma is enhanced when combined with immune checkpoint blockade. Cancer Immunol Res. 2014 Jul;2(7):643-54. [Content Brief]
[3]. Wang W, et al. RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer. Cancer Cell. 2018 Nov 12;34(5):757-774.e7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse PD-1 Antibody (29F.1A12) Related Classifications
HY-P990788 Related Classifications
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