Anti-Mouse TNFR2 Antibody (TR75-54.7)
Based on 1 Customer Validation
Anti-Mouse TNFR2 Antibody (TR75-54.7) is an anti-mouse TNFR2 IgG monoclonal antibody. Anti-Mouse TNFR2 Antibody (TR75-54.7) can reduce white blood cell count (WBC) and decrease the expression of some pro-inflammatory cytokines such as CCL2 and CXCL5. Anti-Mouse TNFR2 Antibody (TR75-54.7) can be used for researches on inflammation conditions and cancer such as breast cancer.
For research use only. We do not sell to patients.
- Purity: 98.864%
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Armenian Hamster IgG
Mouse
TNFR2
Anti-Mouse TNFR2 Antibody (TR75-54.7) (5 mg/kg, i.p., twice weekly, for 3 weeks) significantly reduces white blood cell count (WBC) and downregulates some pro-inflammatory cytokines in JAK2+/VF knock-in C57BL/6 mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:1×105 4T1 cells injected female wild-type Balb/c mice (8-12 weeks)[1]
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Dosage:200 μg
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Administration:Intraperitoneal injection (i.p.), single dose, 3 days before inoculation of 4T1 tumor cells
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Result:Significantly prolonged the survival period of mice.
Significantly inhibited tumor volume.
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Animal Model:JAK2+/VF knock-in C57BL/6 mice[2]
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Dosage:5 mg/kg
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Administration:Intraperitoneal injection (i.p.), twice weekly, for 3 weeks
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Result:Significantly reduced white blood cell count (WBC), but did not significantly improve hematocrit (HCT), hemoglobin (HGB), and splenomegaly.
Downregulated some pro-inflammatory cytokines such as CCL2 and CXCL5, but upregulated other inflammatory markers such as CXCL2 and IL-12.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
in vivo TNFR2 blockade; in vitro TNFR2 blockade
Chemical Information
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Appearance Liquid
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Molecular Weight 150 kDa
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Color Colorless to light yellow
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SMILES
[Anti-Mouse TNFR2 Antibody (TR75-54.7)]
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (261 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Nie Y, et al. Blockade of TNFR2 signaling enhances the immunotherapeutic effect of CpG ODN in a mouse model of colon cancer. Sci Signal. 2018 Jan 2;11(511):eaan0790. [Content Brief]
[2]. Müller P, et al. Anti-inflammatory treatment in MPN: targeting TNFR1 and TNFR2 in JAK2-V617F-induced disease. Blood Adv. 2021 Dec 14;5(23):5349-5359. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse TNFR2 Antibody (TR75-54.7) Related Classifications
HY-P99149 Related Classifications
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