Antibacterial agent 373
Antibacterial agent 373 is a broad-spectrum antibacterial agent. Antibacterial agent 373 exhibits antibacterial activity against Gram-negative/Gram-positive bacteria and some fungi, with MIC values ranging from 11.25 to 22.5 mg/mL. Antibacterial agent 373 is predicted to target Staphylococcus aureus topoisomerase IV, occupy the novobiocin binding pocket, and form hydrogen bonds with the active site residues Asn49 and Glu53. Antibacterial agent 373 can be used in studies related to bacterial and Candida infections.
For research use only. We do not sell to patients.
- CAS No.: 668468-75-5
- Formula: C11H9Cl2N3O
- Molecular Weight:270.11
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Antibacterial agent 373 (compound 3) exhibits broad-spectrum antibacterial activity and produces measurable growth inhibition zones against Escherichia coli ATCC 25922, Helicobacter pylori ATCC 43526, Bacillus cereus ATCC 6629, Staphylococcus aureus ATCC 6538, and Candida albicans ATCC 10231 [1].
Antibacterial agent 373 exhibits stable broad-spectrum inhibitory activity, with MIC values of 22.5 × 103 μg/mL against Escherichia coli, Helicobacter pylori, and Candida albicans, and MIC values of 11.25 × 103 μg/mL against Bacillus cereus and Staphylococcus aureus[1].
Antibacterial agent 373 exhibits favorable binding to the active site of S. aureus topoisomerase IV, with a docking score of -6.49 kcal/mol, and forms distinct hydrogen bond interactions with residues Asn49 and Glu53[1].
Antibacterial agent 373 exhibits an optimal balance between lipophilicity and polarity, with a consensus logP of 2.84 and a TPSA of 47.78 Å2, a property that is consistent with its observed broad-spectrum whole-cell antibacterial activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 668468-75-5
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Molecular Weight 270.11
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Formula C11H9Cl2N3O
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SMILES
ClC1=C(N2C(C)=C(C(C)=O)N=N2)C=CC(Cl)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antibacterial agent 373 Related Classifications
HY-189127 Related Classifications
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Keywords
- Antibacterial agent 373
- 668468-75-5
- Antibacterial agent373
- Antibacterial agent-373
- Bacterial
- Fungal
- 1,2,3-triazole derivatives
- Gram-positive bacteria
- Gram-negative bacteria
- novobiocin
- Escherichia coli ATCC 25922
- Staphylococcus aureus topoisomerase IV
- Helicobacter pylori ATCC 43526
- Candida albicans
- Bacillus cereus ATCC 6629
- Staphylococcus aureus ATCC 6538
- Inhibitor
- inhibitor
- inhibit