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United States

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製品番号: HY-189127

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Antibacterial agent 373

Antibacterial agent 373 is a broad-spectrum antibacterial agent. Antibacterial agent 373 exhibits antibacterial activity against Gram-negative/Gram-positive bacteria and some fungi, with MIC values ranging from 11.25 to 22.5 mg/mL. Antibacterial agent 373 is predicted to target Staphylococcus aureus topoisomerase IV, occupy the novobiocin binding pocket, and form hydrogen bonds with the active site residues Asn49 and Glu53. Antibacterial agent 373 can be used in studies related to bacterial and Candida infections.

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CAS 番号: 668468-75-5
分子式: C₁₁H₉Cl₂N₃O
分子量:270.11

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (280 KB)

Antibacterial agent 373 構造式

CAS 番号: 668468-75-5

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

Bacterial InfectionFungal Infection

Bacterial Infection

Fungal Infection

Antibacterial agent 373 (compound 3) exhibits broad-spectrum antibacterial activity and produces measurable growth inhibition zones against Escherichia coli ATCC 25922, Helicobacter pylori ATCC 43526, Bacillus cereus ATCC 6629, Staphylococcus aureus ATCC 6538, and Candida albicans ATCC 10231 ^[1].
Antibacterial agent 373 exhibits stable broad-spectrum inhibitory activity, with MIC values of 22.5 × 10³ μg/mL against Escherichia coli, Helicobacter pylori, and Candida albicans, and MIC values of 11.25 × 10³ μg/mL against Bacillus cereus and Staphylococcus aureus^[1].

Bacterial Infection

Antibacterial agent 373 exhibits favorable binding to the active site of S. aureus topoisomerase IV, with a docking score of -6.49 kcal/mol, and forms distinct hydrogen bond interactions with residues Asn49 and Glu53^[1].
Antibacterial agent 373 exhibits an optimal balance between lipophilicity and polarity, with a consensus logP of 2.84 and a TPSA of 47.78 Å², a property that is consistent with its observed broad-spectrum whole-cell antibacterial activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

化学情報

CAS 番号 668468-75-5
分子量 270.11
分子式 C₁₁H₉Cl₂N₃O
SMILES

ClC1=C(N2C(C)=C(C(C)=O)N=N2)C=CC(Cl)=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (280 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Sallam MN, et al. Rational design, synthesis, and antimicrobial evaluation of novel 1,2,3-triazole hybrids: structure-activity relationships, molecular docking, and DFT studies. Scientific reports. 2026 Aug 11;16(1):24903.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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