CD68 Antibody (YA7191)
(Synonyms: CD68; Macrosialin; Gp110; CD68)
Based on 1 Customer Validation
CD68 Antibody (YA7191) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD68.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P, ICC/IF, FC, IF-Tissue, mIHC
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Reactivity :
Human
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Formulation:
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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mIHC
mIHC: Multiplex Immunohistochemical
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IF-Tissue
IF-Tissue: Immunofluorescence-Tissue
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|---|---|---|---|---|---|
| Dilution Ratio | 1:200-1:4000 | 1:100 | 1:500-1:1000 | 1:500-1:2000 | 1:50-1:800 |
Product Details
CD68 Antibody (YA7191) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD68.
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Host Mouse
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Clonality Monoclonal,Recombinant
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Species ReactivityHuman
Recombinant protein within Human CD68 aa 1-354.
affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CD68: This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms.
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Expression
Tissue_specificity:It is highly expressed in blood monocytes and tissue macrophages. It is also expressed in lymphocytes, fibroblasts, and endothelial cells. It is expressed in many tumor cell lines, which may enable them to attach to selectins on vascular endothelium, thereby promoting their spread to secondary sites.
Positive sample: Human spleen tissue, human diffuse large B-cell lymphoma tissue, human tonsil tissue, human liver tissue, THP-1 -
Isoforms & Post-Translational Modification
CD68 has 3 isomers: P34810-1: 37408 Da (predicted); P34810-2: 31738 Da (predicted); P34810-3: 34654 Da (predicted).
N- and O-glycosylated -
Synonyms
CD68; Macrosialin; Gp110; CD68
Documentation
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Data Sheet (234 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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User Guide for Antibodies (1077 KB)
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