CD68 - CD68 molecule Gene

Also Known as GP110; LAMP4; SCARD1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 968

About CD68

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,579,638-7,582,111 (from NCBI)

This gene has 4 transcripts (splice variants), 131 orthologues and 3 paralogues. Broad expression in spleen (RPKM 159.3), lung (RPKM 115.5) and 19 other tissues.

Summary

This gene encodes a 110-kD Transmembrane Glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]

CD68 Products (2)

mRNA	Protein	Name
NM_001040059.2	NP_001035148.1	macrosialin isoform B precursor
NM_001251.3	NP_001242.2	macrosialin isoform A precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	28601280	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD68 Protein Structure

Lamp

0
100
200
300
354 a.a.

Protein Preferred Names	Protein Names
macrosialin	CD68 antigen

CD68 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CD68	P34810	TOMM6	Homo sapiens	Q96B49	Y2H Prey Pooling	32296183
Intra	CD68	P34810	TOMM6	Homo sapiens	Q96B49	Validated Y2H	32296183
Intra	CD68	P34810	TOMM6	Homo sapiens	Q96B49	Y2H Array	32296183
Intra	CD68	P34810	TMEM179B	Homo sapiens	Q7Z7N9	Y2H Prey Pooling	32296183
Intra	CD68	P34810	TMEM179B	Homo sapiens	Q7Z7N9	Validated Y2H	32296183
Intra	CD68	P34810	TMEM179B	Homo sapiens	Q7Z7N9	Y2H Array	32296183
Intra	CD68	P34810	CLEC2D	Homo sapiens	Q9UHP7-3	Y2H Prey Pooling	32296183
Intra	CD68	P34810	CLEC2D	Homo sapiens	Q9UHP7-3	Validated Y2H	32296183
Intra	CD68	P34810	CLEC2D	Homo sapiens	Q9UHP7-3	Y2H Array	32296183
Intra	CD68	P34810	KTN1	Homo sapiens	Q86UP2-3	Validated Y2H	32296183
Intra	CD68	P34810	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	CD68	P34810	AQP6	Homo sapiens	Q13520	Validated Y2H	32296183
Intra	CD68	P34810	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	CD68	P34810	MUC1	Homo sapiens	P15941-11	Y2H Array	32296183
Intra	CD68	P34810	MUC1	Homo sapiens	P15941-11	Y2H Prey Pooling	32296183
Intra	CD68	P34810	PLEKHB2	Homo sapiens	Q96CS7	Y2H Array	32296183
Intra	CD68	P34810	PLEKHB2	Homo sapiens	Q96CS7	Y2H Prey Pooling	32296183
Intra	CD68	P34810	PLEKHB2	Homo sapiens	Q96CS7	Validated Y2H	32296183
Intra	CD68	P34810	AGR2	Homo sapiens	O95994	Y2H Prey Pooling	32296183
Intra	CD68	P34810	AGR2	Homo sapiens	O95994	Y2H Array	32296183
Intra	CD68	P34810	SGTB	Homo sapiens	Q96EQ0	Validated Y2H	32296183
Intra	CD68	P34810	SGTB	Homo sapiens	Q96EQ0	Y2H Array	32296183
Intra	CD68	P34810	SGTB	Homo sapiens	Q96EQ0	Y2H Prey Pooling	32296183
Intra	CD68	P34810	MAL2	Homo sapiens	Q969L2	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD68 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70028	CD68 Protein, Human (HEK293, Fc)	P34810 (N22-I320)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P74279	CD68 Protein, Human (sf9, His)	P34810 (N22-S319)	≥ 95%, as determined by reducing SDS-PAGE.

CD68 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80066	CD68 Antibody (YA798)	WB, IHC-P, FC	Human
HY-P80067	CD68 Antibody (YA529)	WB	Human
HY-P80605	CD68 Antibody (YA799)	IHC-P, ICC/IF	Human, Mouse, Rat
HY-P84267	CD68 Antibody (YA3964)	WB, IHC-P, ICC/IF, FC, ELISA	Human
HY-P84267A	CD68 Antibody (YA3964)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human
HY-P86360	CD68 Antibody (YA6052)	WB, IHC-P, ICC/IF, IP, ELISA	Mouse, Rat
HY-P87507	CD68 Antibody (YA7191)	IHC-P, ICC/IF, FC, IF-Tissue, mIHC	Human

Related Diseases

Diseases	Alias
Granular Cell Tumor	Abrikosov'S Tumor Neoplasm Of Granular Cell Abrikosoff'S Granulous Cell Tumor Abrikosoff'S Tumor Giant Granulocellular Abrikosov'S Tumor Malignant Variant Of Abrikosov'S Tumor Carcinoma, Granular Cell
Histiocytic Sarcoma	Malignant Histiocytosis
Malignant Fibrous Histiocytoma	Undifferentiated Pleomorphic Sarcoma Ups Histiocytoma, Malignant Fibrous Fibroxanthosarcoma Mfh Malignant Fibrohistiocytic Tumors Histiocytoma, Fibrous, Malignant
Congenital Granular Cell Tumor
Neuroma
Follicular Dendritic Cell Sarcoma	Dendritic Cell Sarcoma Dendritic Cell Sarcoma, Follicular Follicular Dendritic Cell Tumour Dendritic Cell Sarcoma, Interdigitating Dendritic Cell Sarcoma, Not Otherwise Specified
Synovitis
Multicentric Reticulohistiocytosis	Lipoid Dermatoarthritis Giant Cell Histiocytomatosis
Axillary Lipoma	Lipoma Of Axilla
Myoblastoma	Benign Granular Cell Tumor
Granulomatous Dermatitis
Xanthogranulomatous Pyelonephritis	Pyelonephritis, Xanthogranulomatous
Verruciform Xanthoma Of Skin	Verruciform Xanthoma Cutaneous Verruciform Xanthoma
Reticulosarcoma	Histiocytic Lymphoma Large-Cell Lymphomas Lymphoma, Large-Cell Lymphoma Large Cell Diffuse Large B-Cell Lymphoma Histiocytic Sarcoma
Breast Granular Cell Tumor
Balloon Cell Malignant Melanoma
Malignant Inflammatory Fibrous Histiocytoma	Inflammatory Mfh Xanthosarcoma
Langerhans Cell Histiocytosis	Histiocytosis X Lch Langerhans Cell Granulomatosis Langerhans-Cell Histiocytosis Letterer-Siwe Disease Hashimoto-Pritzger Disease Histiocytosis, Langerhans-Cell Langerhan'S Cell Histiocytosis Letterer-Siwe Disease Involving Intra-Abdominal Lymph Nodes Letterer-Siwe Disease Involving Intrapelvic Lymph Nodes Letterer-Siwe Disease Involving Intrathoracic Lymph Nodes Letterer-Siwe Disease Involving Lymph Nodes Of Axilla And Upper Limb Letterer-Siwe Disease Involving Lymph Nodes Of Head, Face And Neck Letterer-Siwe Disease Involving Lymph Nodes Of Head, Face, And Neck Letterer-Siwe Disease Involving Lymph Nodes Of Inguinal Region And Lower Limb Letterer-Siwe Disease Involving Lymph Nodes Of Multiple Sites Letterer-Siwe Disease Involving Spleen Letterer-Siwe Disease Of Intra-Abdominal Lymph Nodes Letterer-Siwe Disease Of Intrapelvic Lymph Nodes Letterer-Siwe Disease Of Intrathoracic Lymph Nodes Letterer-Siwe Disease Of Lymph Nodes Of Axilla And Upper Limb Letterer-Siwe Disease Of Lymph Nodes Of Axilla And/Or Upper Limb Letterer-Siwe Disease Of Lymph Nodes Of Head, Face And Neck Letterer-Siwe Disease Of Lymph Nodes Of Head, Face And/Or Neck Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region Amd/Or Lower Limb Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region And Lower Limb Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb Letterer-Siwe Disease Of Lymph Nodes Of Multiple Sites Letterer-Siwe Disease Of Spleen Familial Letterer-Siwe Disease Langerhans-Cell Histiocytosis Nos
Epulis	Epulides Gingival Polyp Polyp Of Gum
Congenital Epulis	Gingival Neoplasms Congenital Epulides Congenital Gingival Cell Tumor Congenital Granular Cell Tumor Neumann Tumor
Connective Tissue Benign Neoplasm	Soft Tissue Neoplasms Mesenchymal Tissue Neoplasm Neoplasm Of Soft Tissue Neoplasm Of Soft Tissues Soft Tissue Benign Neoplasm Tumor Of The Soft Tissue Soft Tissue Neoplasm
Non-Langerhans-Cell Histiocytosis	Histiocytosis, Non-Langerhans-Cell Non-Langerhans Cell Histiocytosis
Fibroma
Granuloma Annulare	Granulome Annulare Ga - [Granuloma Annulare]
Cutaneous Leiomyosarcoma	Leiomyosarcoma Of The Skin
Malignant Granular Cell Myoblastoma	Malignant Granular Cell Tumor Granular Cell Tumor, Malignant Malignant Granular Cell Neoplasm
Pulmonary Artery Leiomyosarcoma	Leiomyosarcoma Of The Pulmonary Artery
Malignant Giant Cell Tumor Of Soft Parts	Malignant Giant Cell Neoplasm Of Soft Parts
Pigmented Villonodular Synovitis	Diffuse Giant Cell Tumor Of Tenosynovium Villous Tenosynovitis Diffuse Pigmented Villonodular Synovitis Diffuse-Type Gct Diffuse-Type Giant Cell Tumor Localized Pigmented Villonodular Synovitis Tgct Tsgct Tenosynovial Giant Cell Tumor Tenosynovial Giant Cell Tumors Synovitis Pigmented Villonodular Synovitis, Pigmented Villonodular Fibrous Histiocytoma Of Tendon Sheath Testicular Germ Cell Tumor Chronic Haemorrhagic Villous Synovitis Pvns - [Pigmented Villonodular Synovitis] Villonodular Synovitis
Vulvar Granular Cell Tumor
Anterior Foramen Magnum Meningioma	Meningioma Of The Anterior Foramen Magnum
Reticulohistiocytic Granuloma	Reticulohistiocytoma Solitary Reticulohistiocytoma Solitary Histiocytoma Solitary Reticulohistiocytosis
Rhinoscleroma
Histiocytic And Dendritic Cell Cancer	Histiocytic And Dendritic Cell
Tenosynovial Giant Cell Tumor	Fibrous Histiocytoma Of Tendon Sheath Giant Cell Tumor Of Tendon Sheath Giant Cell Tumor Of Tenosynovium Giant Cell Tumour Of Tendon Sheath Giant Cell Tumour Of Tenosynovium Tenosynovial Giant Cell Tumour Diffuse-Type Gct Diffuse-Type Giant Cell Tumor Pigmented Villonodular Synovitis Tgct Tsgct
Hemangioma Of Spleen	Splenic Hemangioma
Pancytopenia
Cutaneous Fibrous Histiocytoma	Dermatofibroma Fibrohistiocytic Tumor Benign Cutaneous Fibrous Histiocytoma Fibrous Histiocytoma Of Skin Fibrous Xanthoma Of Skin Pleomorphic Fibroma Sclerosing Angioma Sclerosing Angioma Of Skin Fibrous Histiocytoma
Interdigitating Dendritic Cell Sarcoma	Interdigitating Cell Sarcoma Dendritic Cell Sarcoma, Interdigitating Reticulum Cell Sarcoma
Sarcomatoid Transitional Cell Carcinoma	Transitional Cell Carcinoma, Sarcomatoid Transitional Spindle Cell Carcinoma Transitional Cell Carcinoma, Spindle Cell
Extraosseous Osteosarcoma	Extraskeletal Osteosarcoma Extraskeletal Osteogenic Sarcoma
Granulomatous Orchitis	Non-Specific Granulomatous Orchitis
Malignant Giant Cell Tumor	Malignant Tumor, Giant Cell Type Malignant Giant Cell Neoplasm
Granulomatous Gastritis
Bone Benign Neoplasm
Glomeruloid Hemangioma
Juvenile Xanthogranuloma	Multiple Eruptive Juvenile Xanthogranuloma Naevoxanthoendothelioma Xanthoma Neviforme Xanthogranuloma, Juvenile
Liposarcoma	Lipomatous Cancer
Myoma	Muscle Benign Neoplasm Myomatous Neoplasm Neoplasms, Muscle Tissue Benign Neoplasm Of The Muscle Muscle Neoplasm Muscle Tissue Neoplasm Myomatous Tumor Neoplasm Of Muscle Muscle Neoplasms Myomas
Langerhans Cell Sarcoma	Malignant Langerhans Cell Sarcoma
Myocarditis	Myocardial Inflammation Inflammatory Cardiomyopathy
Bacterial Esophagitis
Proliferative Fasciitis
Skin Sarcoma	Cutaneous Sarcoma
Myeloid Sarcoma	Granulocytic Sarcoma Chloroma Extramedullary Myeloid Tumor Sarcoma, Granulocytic Sarcoma Granulocytic Sarcoma, Myeloid Myelosarcoma Myeloid Sarcoma Disease Myeloid Sarcoma Nos Myeloid Sarcoma Without Mention Of Remission
Giant Cell Reparative Granuloma	Central Giant Cell Granuloma Central Giant Cell Reparative Granuloma Of Jaw Central Giant Cell Granuloma Granuloma, Giant Cell Granuloma, Giant Cell Reparative Giant Cell Lesion Of Small Bones Giant Cell Granuloma, Nos
Necrobiosis Lipoidica	Oppenheim-Urbach Disease Necrobiosis Lipoidica Diabeticorum
Fibrous Histiocytoma	Benign Fibrous Histiocytoma Histiocytoma, Benign Fibrous Fibroxanthoma Histiocytoma Fibrous
Lymphoma, Hodgkin, Classic	Hodgkin Lymphoma Hodgkin Disease Hodgkin'S Lymphoma Hodgkins Lymphoma Classic Hodgkin Lymphoma CHL Hodgkin Lymphoma, Susceptibility To Hl Hodgkin'S Sarcoma Stage I Subdiaphragmatic Hodgkin Lymphoma Stage Ii Subdiaphragmatic Hodgkin Lymphoma Lymphoma, Hodgkin'S Classic Hodgkin Disease Hodgkin'S Disease Lymphoma, Hodgkin, Susceptibility To Hodgkin'S Disease Of Intrapelvic Lymph Nodes Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb Malignant Lymphogranuloma Malignant Lymphogranulomatosis Malignant Hodgkin Lymphoma Classical Hodgkin Lymphoma, Type Not Specified
Fox-Fordyce Disease	Fox Fordyce Disease Apocrine Miliaria Fox-Fordyce Syndrome Miliaria, Apocrine
Peripheral Neuropathy With Variable Spasticity, Exercise Intolerance, And Developmental Delay	Combined Oxidative Phosphorylation Deficiency 26 COXPD26 Combined Oxidative Phosphorylation Defect Type 26 PNSED Oxidative Phosphorylation Deficiency, Combined, Type 26
Temporal Arteritis	Polymyalgia Rheumatica Giant Cell Arteritis Cranial Arteritis Horton Disease Gca Horton'S Disease Rhizomelic Pseudopolyarthritis Arteritis Cranialis Arteritis Temporalis Horton'S Arteritis Horton'S Giant Cell Arteritis Horton'S Temporal Arteritis Horton'S Syndrome Gca - [Giant Cell Arteritis] Senile Arthritis Polymyalgia Arteritica Pmr - [Polymyalgia Rheumatica] Forestier-Certonciny Syndrome Rheumatic Polymyalgia Polymyalgia
Fibrosarcoma Of Bone	Malignant Histiocytosis Malignant Fibroxanthoma Malignant Fibrous Histiocytoma Histiocytic Medullary Reticulosis Nasal Type Extranodal Nk/T-Cell Lymphoma Histiocytic Sarcoma
Balo Concentric Sclerosis	Balo'S Concentric Sclerosis Balo Disease Diffuse Cerebral Sclerosis Of Schilder Tumefactive Multiple Sclerosis Concentric Demyelination Balo'S Disease Baló Concentric Sclerosis Encephalitis Periaxialis Concentrica Marburg Variant
Nodular Tenosynovitis	Synovioma, Benign Benign Synovioma Benign Tumor Of Synovium Localized Giant Cell Tumor Of Tenosynovium Giant Cell Tumor Of Tendon Sheath
Lymphoplasmacyte-Rich Meningioma	Lymphoplasmocyte-Rich Meningioma Meningioma
Conjunctival Pigmentation
Pseudosarcomatous Fibromatosis	Nodular Fasciitis Pseudosarcomatous Fasciitis Fasciitis - Nodular Fasciitis Nodular
Pleural Lipoma	Lipoma Of Pleura
Cat-Scratch Disease	Cat Scratch Disease Benign Lymphoreticulosis Cat Scratch Fever Debre'S Syndrome Bartonellosis Due To Bartonella Henselae Infection Debre-Mollaret Syndrome Foshay-Mollaret Cat Scratch Fever Oroya Fever Cat-Scratch Fever Benign Inoculation Lymphoreticulosis Catscratch Disease Or Fever Csd - [Cat Scratch Disease] Nonbacterial Regional Lymphadenitis Rochalimaea Henselae Infection
Bone Giant Cell Tumor	Giant Cell Tumor Of Bone Osteoclastoma Gct Of Bone Bone Giant Cell Tumour Giant Cell Myeloma Giant Cell Neoplasm Of Bone Giant Cell Tumour Of Bone
Histiocytosis-Lymphadenopathy Plus Syndrome	H Syndrome Histiocytosis With Joint Contractures And Sensorineural Deafness Faisalabad Histiocytosis Shml Hjcd Rosai-Dorfman Disease Pigmented Hypertrichosis With Insulin-Dependent Diabetes Mellitus Phid Sinus Histiocytosis And Massive Lymphadenopathy Familial Rosai-Dorfman Disease Slc29a3 Spectrum Disorder Sinus Histiocytosis With Massive Lymphadenopathy Histiocytosis And Lymphadenopathy With Or Without Cutaneous, Cardiac, And/Or Endocrine Features, Joint Contractures, And/Or Deafness Hyperpigmentation, Cutaneous, With Hypertrichosis, Hepatosplenomegaly, Heart Anomalies, And Hypogonadism With Or Without Hearing Loss Rosai-Dorfman Disease, Familial Cutaneous Hyperpigmentation With Hypertrichosis, Hepatosplenomegaly, Heart Anomalies, And Hypogonadism With Or Without Hearing Loss Histiocytosis And Lymphadenopathy With Or Without Cutaneous, Cardiac, And/Or Endocrine Features, Joint Contractures And/Or Deafness Rdd Rosaï-Dorfman Disease Slc29a3 Disorder Destombes-Rosai-Dorfman Disease Rosai-Dorfman-Destombes Disease HLAS Cutaneous Hyperpigmentation With Hypertrichosis Hepatosplenomegaly Heart Anomalies And Hypogonadism With Or Without Hearing Loss Histiocytosis And Lymphadenopathy With Or Without Cutaneous Cardiac And/Or Endocrine Features Joint Contractures And/Or Deafness H Disease Sinus Histiocytosis
Epididymal Neoplasm	Neoplasm Of Epididymis
Granulomatous Myositis
Orbital Cancer	Malignant Neoplasm Of Orbit Orbital Tumor Orbital Neoplasms Neoplasm Of Orbit Proper Orbit Cancer Primary Malignant Neoplasm Of Orbit Intraorbital Cancer
Orchitis	Inflammation Of Testis Orchititis Mumps Orchitis
Lung Giant Cell Carcinoma	Carcinoma, Giant Cell Giant Cell Carcinoma Giant Cell Lung Carcinoma Carcinoma Giant Cell Giant Cell Carcinoma Of Lung
Skin Benign Neoplasm	Neoplasm Of Skin By Site Tumor Of The Skin Skin Tumor Benign Neoplasm Of Skin Skin Neoplasms
Verrucous Carcinoma	Verrucous Squamous Carcinoma Verrucous Squamous Cell Carcinoma Warty Carcinoma Carcinoma Verrucous Carcinoma, Verrucous
Aortic Atherosclerosis	Atherosclerosis Of Aorta Aorta Atheroma Aorta Calcification Aorta Arteriosclerosis Aortic Degeneration Aortic Calcification Aortic Atheroma Aortic Arteriosclerotic Disease Aortic Arteriosclerosis Aorta Sclerosis Aorta Degeneration Atheromatous Aortic Calcified Aortic Stenosis Atheromatous Aorta Arteriosclerotic Aortitis Arteriosclerotic Aortic Stenosis Arteriosclerotic Aorta Disease Aortic Sclerosis
Chronic Pyelonephritis
Carotid Artery Disease	Carotid Artery Diseases Disorder Of Carotid Artery
Mooren'S Ulcer	Mooren Ulcer Moorens Ulcer
Benign Giant Cell Tumor	Giant Cell Tumors
Inflammatory Myofibroblastic Tumor	Inflammatory Fibrosarcoma
Neurosarcoidosis	Cerebral Sarcoidosis
Exophthalmos	Proptosis
Whipple Disease	Intestinal Lipodystrophy Whipple'S Disease Intestinal Lipophagic Granulomatosis Secondary Non-Tropical Sprue Tropheryma Whippelii Infection Whipples Disease
Granulomatous Angiitis	Vasculitis, Central Nervous System
Bronchopneumonia	Lobular Pneumonia Bronchial Pneumonia Chest Infection - Bronchopneumonia
Malignant Mesenchymoma	Malignant Mesenchymal Tumor Mesenchymoma, Malignant Sarcoma Rat Malignant Renal Mesenchymal Tumor
Central Nervous System Vasculitis	Vasculitis, Central Nervous System
Pericardium Disease
Cobblestone Retinal Degeneration	Paving Stone Retinal Degeneration Paving Stone Degeneration Of Retina
Lymphohistiocytoid Mesothelioma
Arteriolosclerosis
Acute Proliferative Glomerulonephritis	Acute Glomerulonephritis With Lesion Of Proliferative Glomerulonephritis Acute Post-Streptococcal Glomerulonephritis
Crescentic Glomerulonephritis	Idiopathic Crescentic Glomerulonephritis
Acute Myocarditis
Mesenchymal Cell Neoplasm	Benign Miscellaneous Mesenchymal Tumor Mesenchymal Tumor Mesenchymal Tumors
Funisitis
Pancreas Sarcoma	Sarcoma Of Pancreas
Bartonellosis	Bartonella Infections Bartonella Infectious Disease Bartonelliasis Rochalimaea Infection Bartonellosis, Unspecified
Extrinsic Cardiomyopathy
Hypersensitivity Reaction Type Iv Disease	Immunoproliferative Disorders Immunoproliferative Disease
Orbital Disease	Orbit Orbital Diseases
Pericardial Effusion	Noninflammatory Pericardial Effusion Pericardium Effusion
Vascular Cancer	Blood Vessel Tumors Malignant Vascular Neoplasm Renal Vein Leiomyosarcoma Vascular Neoplasms Blood Vessel Neoplasm Blood Vessel Tumor Blood Vessel Tumour Disorder Haemangiomatous Tumour Leiomyosarcoma Of The Renal Vein Malignant Great Vessel Tumor Malignant Tumor Of Pulmonary Artery Malignant Tumor Of Pulmonary Vein Malignant Vascular Tumor Neoplasm Of Great Vessel Pulmonary Artery Malignant Neoplasm Pulmonary Vein Malignant Neoplasm Vascular Tissue Neoplasm Vascular Tumors Blood Vessel Cancer Neoplasms, Vascular Tissue Malignant Neoplasm Of Great Vessels
Myxofibrosarcoma	Fibromyxosarcoma Fibromyxoid Sarcoma Myxoid Malignant Fibrous Histiocytoma Dermatofibrosarcoma Protuberans, Myxoid
Fibrolamellar Carcinoma	Fibrolamellar Hepatocellular Carcinoma Fhcc Fibrolamellar Hepatocarcinoma Hepatocellular Carcinoma, Fibrolamellar Oncocytic Hepatocellular Tumor Eosinophilic Glassy Cell Hepatoma Eosinophilic Hepatocellular Carcinoma With Lamellar Fibrosis Fl-Hcc Fibrolamellar Oncocytic Hepatoma Hepatocellular Carcinoma With Increased Stromal Fibrosis Polygonal Cell Hepatocellular Carcinoma With Fibrous Stroma
Chest Wall Lipoma	Lipoma Of The Chest Wall Lipoma Of Chest Wall
Heart Lymphoma	Lymphoma Of Heart Cardiac Lymphoma
Esophageal Tuberculosis	Tuberculosis Of Esophagus
Dermatofibrosarcoma Protuberans	DFSP Dermatofibrosarcoma Giant Cell Fibroblastoma Metastatic Dermatofibrosarcoma Protuberans Familial Dermatofibrosarcoma Protuberans Darier-Ferrand Tumor Darier-Hoffmann Tumor
Gaucher Disease, Perinatal Lethal	Gaucher Disease Perinatal Lethal Gaucher Disease, Collodion Type Gaucher'S Disease Perinatal Lethal Fetal Gaucher Disease Perinatal Lethal Gaucher Disease Gaucher Disease Collodion Type Gaucher Disease, Perinatal-Lethal Form GDPL
Heart Leiomyosarcoma	Leiomyosarcoma Of Heart Cardiac Leiomyosarcoma
Leukoencephalopathy, Hereditary Diffuse, With Spheroids 1	Hereditary Diffuse Leukoencephalopathy With Spheroids Adult-Onset Leukoencephalopathy With Axonal Spheroids And Pigmented Glia Alsp Gpsc Subcortical Gliosis Of Neumann Leukoencephalopathy, Diffuse Hereditary, With Spheroids 1 Autosomal Dominant Leukoencephalopathy With Neuroaxonal Spheroids Hdls HDLS1 Leukoencephalopathy, Adult-Onset, With Axonal Spheroids And Pigmented Glia Gliosis, Familial Progressive Subcortical Leukoencephalopathy, Diffuse Hereditary, With Spheroids Pold Pigmentary Orthochromatic Leukodystrophy Hereditary Diffuse Leukoencephalopathy With Axonal Spheroids And Pigmented Glia Familial Progressive Subcortical Gliosis Leukoencephalopathy With Neuroaxonal Spheroids, Autosomal Dominant Dementia, Familial, Neumann Type Adult-Onset Leukodystrophy With Neuroaxonal Spheroids Hereditary Diffuse Leukoencephalopathy With Axonal Spheroids Neuroaxonal Leukodystrophy Fpsg Familial Dementia, Neumann Type Familial Dementia Neumann Type Leukoencephalopathy, Diffuse Hereditary, With Spheroid
Meningioma, Familial	Meningioma Familial Meningioma Meningioma, Familial, Susceptibility To Meningeal Neoplasm Meningeal Neoplasms Meningiomas Meningioma, Nf2-Related, Somatic Meningioma, Sis-Related Meningothelial Cell Tumor Neoplasm Of The Meninges Primary Meningeal Tumor Familial Multiple Meningioma MNGMA Meningioma, Benign, No Icd-O Subtype Intracranial Meningioma Meningothelial Cell Neoplasm Supratentorial Meningioma Primary Neoplasm Of Spinal Meninges Benign Intracranial Meningioma Benign Meningioma Meningeal Tumours Meningeal Sarcoma Of Unspecified Site Meningothelial Sarcoma Of Unspecified Site
Encephalomalacia
Vaginal Carcinosarcoma	Malignant Vaginal Mixed Epithelial And Mesenchymal Tumor Vaginal Malignant Mixed Mesodermal Tumor Vaginal Malignant Mixed Mullerian Tumor Vaginal Mixed Epithelial And Mesenchymal Tumor
Lymph Node Disease	Abnormality Of The Lymph Nodes Disorder Of Lymph Node
Aortic Aneurysm, Familial Abdominal, 1	Abdominal Aortic Aneurysm Aortic Aneurysm, Familial Abdominal 1 Aneurysm, Abdominal Aortic AAA Aortic Aneurysm, Abdominal AAA1 Aortic Aneurysm, Familial Abdominal Aortic Aneurysm Abdominal Abdominal Aortic Aneurysms Abdominal Aortic Aneurysm Without Mention Of Perforation Or Rupture Abdomen Aneurysm Abdominal Aorta Aneurysm Aneurysm Of Abdominal Aorta Aortic Abdomen Aneurysm Aaa - [Abdominal Aortic Aneurysm] Abdominal Aneurysm Abdominal Aorta Aneurysm Rupture Abdominal Aorta Aneurysm Ruptured Abdominal Aortic Aneurysm Which Has Ruptured Ruptured Aaa Abdomen Aorta Aneurysm Ruptured Abdomen Aorta Rupture Abdomen Aortic Aneurysm Rupture Abdomen Aneurysm Rupture Abdomen Aortic Aneurysm Ruptured Abdomen Aortic Rupture Abdominal Aorta Rupture Abdominal Aortic Rupture Rupture Abdomen Aorta Aneurysm Rupture Abdominal Aortic Aneurysm Ruptured Abdomen Aneurysm Ruptured Abdomen Aorta Ruptured Abdomen Aortic Ruptured Abdominal Aneurysm Ruptured Abdominal Aorta Ruptured Abdominal Aortic Ruptured Aorta Abdominalis Aneurysm False Abdomen Aorta Aneurysm Ruptured False Abdominal Aortic Aneurysm Ruptured False Abdominal Aorta Aneurysm Ruptured False Abdomen Aortic Aneurysm Ruptured
Malignant Giant Cell Tumor Of The Tendon Sheath	Giant Cell Tumour Of Tendon Sheath, Malignant Malignant Giant Cell Neoplasm Of The Tendon Sheath
Urinary Tract Obstruction	Obstructive Uropathy Urinary Obstruction Urologic Diseases
Frontal Sinus Benign Neoplasm	Neoplasm Of Frontal Sinus Tumor Of The Frontal Sinus
Maxillonasal Dysplasia, Binder Type	Binder Syndrome Binder Type Maxillonasal Dysplasia Maxillonasal Dysplasia Maxillonasal Dysostosis
Breast Leiomyosarcoma	Leiomyosarcoma Of The Breast
Cavernous Hemangioma	Hemangioma, Cavernous Cavernoma Cavernous Haemangioma
Sarcoidosis 1	Sarcoidosis Boeck Sarcoid Besnier-Boeck-Schaumann Disease SS1 Sarcoidosis, Susceptibility To, 1 Lymphogranulomatosis Hodgkin Disease Boeck'S Disease Boeck'S Sarcoid Schaumann'S Disease Or Syndrome Hutchinson-Boeck Disease Or Syndrome
Skin Granular Cell Tumor	Granular Cell Neoplasm Of The Skin Granular Cell Tumor Of Skin Granular Cell Tumour Of Skin Skin Granular Cell Tumour
Lipoprotein Quantitative Trait Locus	Coronary Artery Disease Coronary Artery Anomaly Coronary Artery Disease, Susceptibility To Myocardial Ischemia Congenital Anomaly Of Coronary Artery Coronary Arteriosclerosis Coronary Disease Coronary Heart Disease Coronary Artery Disorder LPAQTL Lpa Deficiency, Congenital Coronary Artery Abnormality Coronary Artery Anomaly, Congenital Chd Coronary Syndrome Congenital Malformations Of Coronary Vessels Malformation Of Coronary Vessels Congenital Coronary Artery Anomaly Congenital Coronary Artery Deformity Congenital Coronary Artery Disorder Abnormal Coronary Artery Congenital Coronary Artery Malposition Congenital Coronary Disease Congenital Anomaly Of Coronary Arteries
Cardiomyopathy, Infantile Histiocytoid	Histiocytoid Cardiomyopathy Foamy Myocardial Transformation Of Infancy Infantile Histiocytoid Cardiomyopathy Infantile Xanthomatous Cardiomyopathy Oncocytic Cardiomyopathy Cardiomyopathy, Infantile Xanthomatous Cardiomyopathy, Focal Lipid Cardiomyopathy, Oncocytic Focal Lipid Cardiomyopathy Infantile Cardiomyopathy With Histiocytoid Change CMIH Cardiomyopathy Focal Lipid Cardiomyopathy Infantile Xanthomatous Cardiomyopathy Oncocytic
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Aortic Aneurysm, Familial Thoracic 1	Thoracic Aortic Aneurysm Annuloaortic Ectasia Familial Thoracic Aortic Aneurysm And Aortic Dissection Familial Aortic Dissection Familial Taad Familial Thoracic Aortic Aneurysm Congenital Aneurysm Of Ascending Aorta Familial Aortic Aneurysm Familial Thoracic Aortic Aneurysm And Dissection Aortic Aneurysm, Thoracic AAT1 Faa1 Aortic Dissection, Familial Aortic Aneurysm, Familial Thoracic Aneurysm, Thoracic Aortic Faa Ftaad Taa Taad Cystic Medial Necrosis Of Aorta Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection Aortic Aneurysm Thoracic Familial Aortic Aneurysms Aneurysm, Aortic, Thoracic, Familial, Type 1 Aneurysm Of Thoracic Aorta Intrathoracic Aneurysm Thoracic Aorta Aneurysm Thoracic Aortic Aneurysm Without Rupture Thoracic Aneurysm Thorax Arterial Aneurysm Thoracic Artery Aneurysm Thoracic Arterial Aneurysm Thorax Aneurysm Thorax Aortic Aneurysm Dissection Of Thoracic Aorta
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Connective Tissue Disease	Connective Tissue Diseases Connective Tissue Disorder Abnormality Of Connective Tissue Disorder Of Connective Tissue Connective Tissue Disorders
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Eye Disease	Eye Diseases Abnormality Of The Eye Toxoplasma Oculopathy
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-157992	LM-021	Inhibitor	98.27%	Unkown
HY-RS02261	CD68 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17050	Cd68 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23494	Cd68 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991840	Anti-CD68 Antibody (KP1)	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CD68	MGD	MGI:88342
Bos taurus	CD68	VGNC	VGNC:27042
Macaca mulatta	CD68	VGNC	VGNC:82121
Felis catus	CD68	VGNC	VGNC:98783
Rattus norvegicus	CD68	RGD	RGD:1305970
Canis familiaris	CD68	VGNC	VGNC:49704
Others	CD68	NCBI