FRK Antibody (YA5039)(PBS only)

Cat. No.: HY-P85347A: Data Sheet User Guide for Antibodies
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FRK Antibody (YA5039) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to FRK.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

* Please select Quantity before adding items.

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

FRK Antibody (YA5039) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to FRK.

Host

Mouse

Molecular Weight

Predicted band size: 58 kDa;

Species Reactivity

Human

SwissProt ID

P42685

Gene ID

2444 [NCBI]

Immunogen

Purified recombinant fragment of FRK (aa2-300) expressed in E. Coli. The exact sequence is proprietary to MCE.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:200-1:1000
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:10000

Purity	affinity purified	Conjugation	Non-conjugated
Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor

Subcellular Localization：Cytoplasm; Nucleus

Expression：
Tissue_specificity:It is primarily expressed in epithelial cell lines and tissues, particularly in normal liver, kidney, mammary gland, and colon.

Isoforms & Post-Translational Modification：P42685 has 2 isomers: P42685-1: 58254 Da (predicted); P42685-2: 41980 Da (predicted).

Subunit：Interacts (via the SH3-domain) with PTEN. Interacts with RB1

Synonyms

FRK; PTK5; RAK; Tyrosine-protein kinase FRK; FYN-related kinase; Nuclear tyrosine protein kinase RAK; Protein-tyrosine kinase 5

Documentation

User Guide for Antibodies (1077 KB)