Antifungal agent 178
Antifungal agent 178 is an indole-oxazole alkaloid analog and a fungal cell membrane disruptor that exhibits low phytotoxicity toward plants. Antifungal agent 178 disrupts the integrity of hyphal cell membranes, leading to cytoplasmic leakage and inhibition of hyphal growth, and induces morphological changes in hyphae. Antifungal agent 178 can be used in research related to fungal plant diseases.
For research use only. We do not sell to patients.
- CAS No.: 848488-07-3
- Formula: C13H12N2O
- Molecular Weight:212.25
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Antifungal agent 178 (Compound Z-2) in the mycelial growth inhibition assay exhibits EC50 = 7.03 mg/L against Rhizoctonia solani, EC50 = 13.5 mg/L against Botrytis cinerea Pers, EC50 = 6.30 mg/L against Pyricularia oryzae, and EC50 = 13.7 mg/L against Fusarium graminearum[1].
Antifungal agent 178 (EC50 100 mg/L; 20-240 min) exerts its antifungal effect by disrupting the cell membrane and increasing its permeability in R. solani and B. cinerea Pers., leading to leakage of intracellular electrolytes[1].
Antifungal agent 178 (100 mg/L) causes hyphal distortion, shrinkage, rupture, plasmolysis, and organelle disintegration in Botrytis cinerea Pers[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Antifungal agent 178 (100 mg/L; spraying) exhibits excellent control activity against Rhizoctonia solani in rice, with a chlorotic lesion diameter of 1.50 cm[1].
Antifungal agent 178 (100-200 mg/L; spraying; 48 h) exhibits low phytotoxicity and excellent safety, and does not inhibit normal mung bean growth[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Tomato fruits[1]
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Dosage:100, 200 mg/L (protective)
100, 200 mg/L (curative) -
Administration:sprayed; placed into an illumination incubator for 4 days.
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Result:At 100 mg/L, exhibited a protective efficacy of 51.2% (lesion diameter 19.8 mm) and a curative efficacy of 43.3% (lesion diameter 21.9 mm).
At 200 mg/L, exhibited a protective efficacy of 98.3% (lesion diameter 6.5 mm) and a curative efficacy of 88.8% (lesion diameter 9.1 mm).
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Animal Model:Mung bean[1]
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Dosage:100 mg/L; 200 mg/L
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Administration:applied; 48 h
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Result:Did not inhibit normal mung bean growth.
Chemical Information
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CAS No. 848488-07-3
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Molecular Weight 212.25
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Formula C13H12N2O
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SMILES
CCN1C=C(C2=CN=CO2)C3=C1C=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antifungal agent 178 Related Classifications
HY-189257 Related Classifications
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