2. Anti-infection Immunology/Inflammation
  3. Enterovirus IFNAR
  4. Antiviral agent 79

Antiviral agent 79 is a broad-spectrum antiviral agent. Antiviral agent 79 exhibits anti-EV71, anti-CVB3 and anti-ADV7 activities. Antiviral agent 79 activates the host type I interferon signaling pathway to enhance antiviral defense. Antiviral agent 79 can be used in research related to viral infections.

For research use only. We do not sell to patients.

Antiviral agent 79

Antiviral agent 79 Chemical Structure

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Antiviral agent 79 Related Antibodies

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Description

Antiviral agent 79 is a broad-spectrum antiviral agent. Antiviral agent 79 exhibits anti-EV71, anti-CVB3 and anti-ADV7 activities. Antiviral agent 79 activates the host type I interferon signaling pathway to enhance antiviral defense. Antiviral agent 79 can be used in research related to viral infections[1].

In Vitro

Antiviral agent 79 (compound 8d) (0-100 μM; 48 h) potently inhibits the replication of EV71 in Vero cells, with an EC50 of 12.86 μM and a CC50 of 175.1 μM and also reduces the production of viral progeny and the number of GFP-positive infected cells in a concentration-dependent manner[1].
Antiviral agent 79 (0-100 μM; 48 h) inhibits CVB3 replication in Hep-2 cells, with an EC50 of 19.58 μM, a CC50 of 156.6 μM and also blocks virus-induced cytopathic effect at high concentrations[1].
Antiviral agent 79 (48 h) inhibits the replication of ADV7 in HeLa cells, with an EC50 of 10.29 μM and a CC50 of 145.8 μM and also blocks virus-induced cytopathic effect at a concentration of 50 μM[1].
Antiviral agent 79 (100 μM; 4-32 h) blocks the replication of EV71 in Vero cells by inhibiting viral RNA synthesis and protein translation[1].
Antiviral agent 79 (50 μM; 32 h) significantly upregulates the expression of IFN-β mRNA and activates the host type I interferon pathway in RD cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antiviral agent 79 Related Antibodies

Real Time qPCR[1]

Cell Line: RD cells
Concentration: 50 μM
Incubation Time: 16, 32 h
Result: Significantly upregulated IFN-β mRNA levels at 32 h post-treatment.
Molecular Weight

538.04

Formula

C27H32ClN7O3
SMILES

O=C(C(NC1=C(C=NC(NC2=CC=C(C=C2)N(C(CN3CCNCC3)=O)C)=N1)Cl)CC4=CC=CC=C4)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antiviral agent 79 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antiviral agent 79Antiviral agent79Antiviral agent-79EnterovirusIFNARRhinovirusHRVHRVsHEVHEVsInterferon-α/β receptorInterferon-alpha/beta receptorCVB3Vero cellsHep-2 cellsADV7type I interferon signaling pathwayEV71HeLa cellsInhibitorinhibitorinhibit

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