2. Metabolic Enzyme/Protease
  3. PAI-1
  4. AS3288802

AS3288802, a highly selective active plasminogen activator inhibitor-1 (PAI-1) antibody, is a PAI-1 inhibitor with a human IC50 and EC50 values of 4.2 ng/mL. AS3288802 can be used for the research of thrombosis and fibrosis-related diseases.

For research use only. We do not sell to patients.

AS3288802

AS3288802 Chemical Structure

Size Stock
1 mg   Get quote  
5 mg   Get quote  
10 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

AS3288802 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

AS3288802, a highly selective active plasminogen activator inhibitor-1 (PAI-1) antibody, is a PAI-1 inhibitor with a human IC50 and EC50 values of 4.2 ng/mL. AS3288802 can be used for the research of thrombosis and fibrosis-related diseases[1].

Species Reactivity

Human
In Vitro

AS3288802 (30 min) potently and selectively binds human active PAI-1 with an EC50 of 4.2 ng/mL[1].
AS3288802 (30 min) potently and selectively binds cynomolgus monkey active PAI-1 with an EC50 of 3.6 ng/mL, while showing minimal binding to cynomolgus monkey latent PAI-1, tPA-PAI-1 complex, and uPA-PAI-1 complex[1].
AS3288802 (30 min) concentration-dependently inhibits active PAI-1 in ex vivo human obese patient plasma with an IC50 of 4.2 ng/mL and in ex vivo LPS (HY-D1056)-administrated cynomolgus monkey plasma with an IC50 of 37 ng/mL[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AS3288802 Related Antibodies
Parmacokinetics
Species Dose Route T1/2
Cynomolgus Monkey[1] 2 mg/kg i.v. 255 h
In Vivo

AS3288802 (2 mg/kg; i.v.; single dose) exhibits a half-life of 255 hours and provides 28 days of over 50% inhibition of plasma active PAI-1 in healthy cynomolgus monkeys[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cynomolgus monkeys (5-7-year-old)[1]
Dosage: 2 mg/kg
Administration: i.v.; single dose
Result: Reached plasma concentration of 51 μg/mL at 0.25 hours after administration.
Demonstrated a half-life (T1/2) of 255 hours.
Reduced plasma active PAI-1 levels to below the detection limit (0.03 ng/mL).
Provided a duration of over 50% inhibition of plasma active PAI-1 concentration of 28 days.
Gene ID

5054  [NCBI]

Accession
Target

Serpin E1/PAI-1
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

AS3288802 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AS3288802AS 3288802AS-3288802PAI-1Plasminogen activator inhibitor-1uPA-PAI-1 complexesLPS-administrated cynomolgus monkey plasmalatent PAI-1thrombosisfibrosis-related diseasescynomolgus monkeyhuman obese patient plasmatPA-PAI-1 complexesactive plasminogen activator inhibitor-1Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
AS3288802
Cat. No.:
HY-P992313
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.