AS3288802
AS3288802, a highly selective active plasminogen activator inhibitor-1 (PAI-1) antibody, is a PAI-1 inhibitor with a human IC50 and EC50 values of 4.2 ng/mL. AS3288802 can be used for the research of thrombosis and fibrosis-related diseases.
For research use only. We do not sell to patients.
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
Species Reactivity
Human
In Vitro
AS3288802 (30 min) potently and selectively binds human active PAI-1 with an EC50 of 4.2 ng/mL[1].
AS3288802 (30 min) potently and selectively binds cynomolgus monkey active PAI-1 with an EC50 of 3.6 ng/mL, while showing minimal binding to cynomolgus monkey latent PAI-1, tPA-PAI-1 complex, and uPA-PAI-1 complex[1].
AS3288802 (30 min) concentration-dependently inhibits active PAI-1 in ex vivo human obese patient plasma with an IC50 of 4.2 ng/mL and in ex vivo LPS (HY-D1056)-administrated cynomolgus monkey plasma with an IC50 of 37 ng/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Parmacokinetics
| Species | Dose | Route | T1/2 |
|---|---|---|---|
| Cynomolgus Monkey[1] | 2 mg/kg | i.v. | 255 h |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Cynomolgus monkeys (5-7-year-old)[1]
-
Dosage:2 mg/kg
-
Administration:i.v.; single dose
-
Result:Reached plasma concentration of 51 μg/mL at 0.25 hours after administration.
Demonstrated a half-life (T1/2) of 255 hours.
Reduced plasma active PAI-1 levels to below the detection limit (0.03 ng/mL).
Provided a duration of over 50% inhibition of plasma active PAI-1 concentration of 28 days.
Gene ID
Accession
Target
Serpin E1/PAI-1
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
-
Product Image
Application
ELISA, FACS, Functional assay
Chemical Information
-
Formulation
Please refer to the lot-specific COA for specific buffer information.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AS3288802 Related Classifications
HY-P992313 Related Classifications
Powered by Bioz