5-Hydroxynoracronycine
5-Hydroxynoracronycine is a selective inhibitor targeting Leishmania, HIV-1 protease, and nitric oxide (NO) production. 5-Hydroxynoracronycine has an IC50 of 93.1 μmol/L against HIV-1 protease and an IC50 of 0.19 mg/mL for scavenging DPPH free radicals. 5-Hydroxynoracronycine exerts anti-leishmanial, anti-HIV, antioxidant and antibacterial activities by inhibiting pathogen proliferation, enzyme activity and inflammation-related NO excessive production. 5-Hydroxynoracronycine can be used in the research of leishmaniasis, HIV infection, and inflammation-related diseases.
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- CAS. Nr.: 27067-70-5
- Formel: C19H17NO4
- Molecular Weight:323.34
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Beschreibung
IC50 & Target
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HIV-1 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
40 μM
Compound: 6
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Antiproliferative activity against human A549 cells after 3 days by alamar blue assay
Antiproliferative activity against human A549 cells after 3 days by alamar blue assay
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[PMID: 10217715] |
In Vitro
The 48-hour EC50 of 5-Hydroxynoracronycine against Leishmania infantum promastigotes is 4.42 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 27067-70-5
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Molecular Weight 323.34
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Formel C19H17NO4
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SMILES
O=C1C2=C(N(C)C3=C4C=CC(C)(C)OC4=CC(O)=C13)C(O)=CC=C2
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Panthong K, et al. Benzene, coumarin and quinolinone derivatives from roots of Citrus hystrix. Phytochemistry. 2013 Apr;88:79-84. [Content Brief]
[2]. Astelbauer F, et al. Anti-leishmanial activity of plant-derived acridones, flavaglines, and sulfur-containing amides. Vector Borne Zoonotic Dis. 2011 Jul;11(7):793-8. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
5-Hydroxynoracronycine Related Classifications
HY-N16745 Related Classifications
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