Lonapalene
Based on 1 Customer Validation
Lonapalene (RS4317) is a topically effective 5-lipoxygenase (5-LO) inhibitor.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.45%
- CAS. Nr.: 91431-42-4
- Formel: C16H15ClO6
- Molecular Weight:338.74
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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5-LO |
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Cell Line
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Type | Value | Description | References |
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| HaCaT | IC50 |
3.2 μM
Compound: lonapalene
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Antiproliferative activity against HaCaT cells
Antiproliferative activity against HaCaT cells
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[PMID: 8201600] |
| RBL-1 | IC50 |
0.5 μM
Compound: RS-43179
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The compound was tested for inhibitory activity against 5-Lipoxygenase in rat RBL-1
The compound was tested for inhibitory activity against 5-Lipoxygenase in rat RBL-1
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[PMID: 1635053] |
| RBL-1 | IC50 |
0.7 μM
Compound: lonapalane
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Ability to inhibit 5-lipoxygenase by using a crude preparation of the cytosolic enzyme from the rat basophilic leukemia (RBL-1) cell line
Ability to inhibit 5-lipoxygenase by using a crude preparation of the cytosolic enzyme from the rat basophilic leukemia (RBL-1) cell line
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[PMID: 2104936] |
| RBL-1 | IC50 |
0.74 μM
Compound: Lonapalene
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Inhibitory activity against 5-lipoxygenase of RBL-1 cell line
Inhibitory activity against 5-lipoxygenase of RBL-1 cell line
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[PMID: 1507204] |
Lonapalene (RS4317) may be useful in the treatment of psoriasis, and that leukotriene B4 is a relevant mediator of the pathology of this disease[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 91431-42-4
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Appearance Solid
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Molecular Weight 338.74
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Formel C16H15ClO6
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Color White to light yellow
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SMILES
COC1=C(OC)C(OC(C)=O)=C2C=CC(Cl)=CC2=C1OC(C)=O
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Synonyms
RS4317
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (295.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.38 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.9521 mL | 14.7606 mL | 29.5212 mL | 73.8029 mL |
| 5 mM | 0.5904 mL | 2.9521 mL | 5.9042 mL | 14.7606 mL | |
| 10 mM | 0.2952 mL | 1.4761 mL | 2.9521 mL | 7.3803 mL | |
| 15 mM | 0.1968 mL | 0.9840 mL | 1.9681 mL | 4.9202 mL | |
| 20 mM | 0.1476 mL | 0.7380 mL | 1.4761 mL | 3.6901 mL | |
| 25 mM | 0.1181 mL | 0.5904 mL | 1.1808 mL | 2.9521 mL | |
| 30 mM | 0.0984 mL | 0.4920 mL | 0.9840 mL | 2.4601 mL | |
| 40 mM | 0.0738 mL | 0.3690 mL | 0.7380 mL | 1.8451 mL | |
| 50 mM | 0.0590 mL | 0.2952 mL | 0.5904 mL | 1.4761 mL | |
| 60 mM | 0.0492 mL | 0.2460 mL | 0.4920 mL | 1.2300 mL | |
| 80 mM | 0.0369 mL | 0.1845 mL | 0.3690 mL | 0.9225 mL | |
| 100 mM | 0.0295 mL | 0.1476 mL | 0.2952 mL | 0.7380 mL |
Lonapalene Related Classifications
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