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Art. -Nr.: HY-146172

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Antioxidant agent-3

Antioxidant agent-3 (Compound 14q), an potent antioxidant, displays potent DPPH radicals scavenging activity and ABTS⁺ scavenging activity with IC₅₀s of 26.58 and 30.31 μM, respectively. Antioxidant agent-3 (Compound 14q) increases reactive oxygen species (ROS), superoxide dismutase (SOD) and glutathione (GSH), and reduced lactate dehydrogenase (LDH) in H₂O₂-treated HepG2 cells.

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CAS. Nr.: 2710376-48-8
Formel: C₁₈H₁₄O₈
Molecular Weight:358.30

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Antioxidant agent-3 Chemical Structure

CAS. Nr.: 2710376-48-8

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Antioxidant agent-3 (Compound 14q) exhibits good activity in DPPH radicals scavenging and ABTS + scavenging with the values of IC₅₀ is 26.58 μM and 30.31 μM respectively^[1].
Antioxidant agent-3 shows low cytotoxicity in human normal WI-38 (IC₅₀ > 100 μM) and GES (IC₅₀ > 200 μM) cells^[1].
Antioxidant agent-3 can enhance viability of H₂O₂-induced HepG2 cells^[1].
Antioxidant agent-3 decreases the apoptotic percentage of HepG2 cells^[1].
Antioxidant agent-3 reduces the ROS produce and LDH release, improves GSH and SOD levels in H₂O₂-treated HepG2 cells, and exhibits more stability in methanol solution^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

WI-38 and GES cells line
Concentration:

200, 100, 50, 25 and 12.5 μM
Incubation Time:

48 h
Result:

Showed less toxicity in hemolysis assay and weaker antiproliferative effects.

Cell Viability Assay^[1]

Cell Line:

H₂O₂-damaged WI-38 and HepG2 cells
Concentration:

50, 25 and 12.5 μM
Incubation Time:

1 h
Result:

Increased cells viability of H2O2-indcued cells and protected the H2O2-indcued cells against injury.

Apoptosis Analysis^[1]

Cell Line:

H₂O₂-damaged HepG2 cells
Concentration:

50, 25 and 12.5 μM
Incubation Time:

1 h
Result:

Protect the H₂O₂-injured HepG2 cells against apoptosis through antioxidant effect.

Chemical Information

CAS. Nr. 2710376-48-8
Molecular Weight 358.30
Formel C₁₈H₁₄O₈
SMILES

O=C(C(C1=O)=CC2=C(O1)C(O)=C(O)C=C2)OCCC3=CC=C(O)C(O)=C3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Wen-Bo Li, et al.Synthesis and antioxidant activity of conjugates of hydroxytyrosol and coumarin. Bioorg Chem. 2020 Dec;105:104427. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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