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Art. -Nr.: HY-123560

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BKM-570

BKM-570 is a nonpeptide bradykinin antagonist with anticancer effects. BKM-570 can be used in the study of lung cancer, prostate cancer and ovarian cancer.

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CAS. Nr.: 259885-54-6
Formel: C₃₄H₃₄Cl₂F₅N₃O₃
Molecular Weight:698.55

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

BKM-570 Chemical Structure

CAS. Nr.: 259885-54-6

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Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

BKM-570 is a nonpeptide bradykinin antagonist with anticancer effects. BKM-570 can be used in the study of lung cancer, prostate cancer and ovarian cancer^[1].

Alle Bradykinin Receptor Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
C6	IC₅₀	4 μM Compound: BKM-570	Cytotoxicity against rat C6 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against rat C6 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 25012567]
Cancer cell lines	IC₅₀	1.8 μM Compound: BKM-570	Cytotoxicity against human Small cell lung cancer cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human Small cell lung cancer cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 25012567]
Granta	IC₅₀	63.3 μM Compound: BKM-570	Cytotoxicity against human Granta cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human Granta cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 25012567]
HEK293	IC₅₀	3.8 μM Compound: BKM-570	Cytotoxicity against HEK293 cells overexpressing CHI3L1 gene assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against HEK293 cells overexpressing CHI3L1 gene assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 25012567]
JeKo-1	IC₅₀	49.3 μM Compound: BKM-570	Cytotoxicity against human Jeko cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human Jeko cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 25012567]
U-373MG ATCC	IC₅₀	3.3 μM Compound: BKM-570	Cytotoxicity against human U373 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human U373 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 25012567]

Chemical Information

CAS. Nr. 259885-54-6
Molecular Weight 698.55
Formel C₃₄H₃₄Cl₂F₅N₃O₃
SMILES

O=C([C@@H](NC(/C=C/C1=C(C(F)=C(C(F)=C1F)F)F)=O)CC2=CC=C(C=C2)OCC3=C(C=CC=C3Cl)Cl)NC4CC(C)(C)NC(C)(C)C4
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Stephanie Jutras, et al. Strong cytotoxic effect of the bradykinin antagonist BKM-570 in ovarian cancer cells--analysis of the molecular mechanisms of its antiproliferative action. FEBS J. 2010 Dec;277(24):5146-60. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
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BKM-570

Alle Bradykinin Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

BKM-570 Related Classifications

HY-123560 Related Classifications