BuChE-IN-7
BuChE-IN-7 is a highly selective inhibitor of hBuChe and eqBuChE with IC50 values of 40 nM, 80 nM respectively. BuChE-IN-7 can promote cognitive with blood-brain penetration and improves situational and phobic memory, showing preference for new things.
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- CAS. Nr.: 3041971-93-8
- Formel: C25H34N2O2
- Molecular Weight:394.55
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
hBCHE 40 nM (IC50) |
eqBCHE 80 nM (IC50) |
In Vitro
BuChE-IN-7 (compound (R)-29) (10 µM; 5 min) inhibits eqBuChE, hBuChE with IC50 values of 0.08 µM, 0.04 µM respectively[1].
BuChE-IN-7 (1, 10, 50 and 100 µM; 72 h) has hepatotoxicity in HepG2 cell line with an IC50 value of 2.85 µM. BuChE-IN-7 decreas the cell activity and shows weaker effect on CYP3A4[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
BuChE-IN-7 (10 mg/kg; i.p.; once daily for 6 days) has insignificant improvement the learning defect caused by scopolamine in mice[1].
BuChE-IN-7 (15 mg/kg and 30 mg/kg; i.p.; single dose) significantly promotes cognition and improves situational and phobic memory of mice, showing preference for new things[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 3041971-93-8
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Molecular Weight 394.55
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Formel C25H34N2O2
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SMILES
O=C(CC(C1=CC=CC=C1)C2=CC=CC=C2)NC[C@H](O)CNCC3CCCCC3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
BuChE-IN-7 Related Classifications
HY-152632 Related Classifications
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