180304-07-8
180304-07-8
Chemical Structure
S-22153
- CAS. Nr.: 180304-07-8
- Formula:C14H17NOS
- Molecular Weight:247.36
IUPAC Name: N-(2-(5-ethylbenzo[b]thiophen-3-yl)ethyl)acetamide
InChIKey: PICRXJDULXLJCZ-UHFFFAOYSA-N
SMILES: CC(NCCC1=CSC2=CC=C(C=C12)CC)=O
Biological Activity: S-22153 is a potent melatonin receptor antagonist with EC50 values of 19 nM, 4.6 nM for hMT1 and hMT2 melatonin receptor, respectively. S-22153 has Ki values of 8.6 nM (CHO cells) and 16.3 nM (HEK cells) for hMT1, and 6.0 nM (CHO cells) and 8.2 nM (HEK cells) for hMT2. S-22153 is a specific ligand of MT1 and MT2 melatonin receptors subtypes[1][2].
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S-22153 | 99.94% | S-22153 is a potent melatonin receptor antagonist with EC50 values of 19 nM, 4.6 nM for hMT1 and hMT2 melatonin receptor, respectively. S-22153 has Ki values of 8.6 nM (CHO cells) and 16.3 nM (HEK cells) for hMT1, and 6.0 nM (CHO cells) and 8.2 nM (HEK cells) for hMT2. S-22153 is a specific ligand of MT1 and MT2 melatonin receptors subtypes. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.67
HY-1331137-Desmethyl-agomelatine -
Similarity Score 0.67
HY-17038RAgomelatine (Standard) -
Similarity Score 0.66
HY-17038ARAgomelatine hydrochloride (Standard) -
Similarity Score 0.65
HY-1331127-Desmethyl-3-hydroxyagomelatine -
Similarity Score 0.65
HY-1331113-Hydroxy agomelatine -
Similarity Score 0.64
HY-B0075RMelatonin (standard) -
Similarity Score 0.64
HY-107854RN-Acetyl-5-hydroxytryptamine (Standard) -
Similarity Score 0.62
HY-133113S7-Desmethyl-agomelatine-d3 -
Similarity Score 0.61
HY-133111S3-Hydroxy agomelatine-d3 -
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References
- [1]. Li XM, et al. Circadian rhythm entrainment with melatonin, melatonin receptor antagonist S22153 or their combination in mice exposed to constant light. J Pineal Res. 2004;37(3):176-184. [Content Brief]
- [2]. Audinot V, et al. New selective ligands of human cloned melatonin MT1 and MT2 receptors. Naunyn Schmiedebergs Arch Pharmacol. 2003;367(6):553-561. [Content Brief]
