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SLU7 - SLU7 homolog, splicing factor Gene

Also Known as 9G8; hSlu7

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10569

About SLU7

Cytogenetic location: 5q33.3 Genomic coordinates (GRCh38): 5:160,401,641-160,419,081 (from NCBI)

This gene has 9 transcripts (splice variants) and 206 orthologues. Ubiquitous expression in brain (RPKM 16.4), thyroid (RPKM 15.4) and 25 other tissues.

Summary

Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in Other splicing factors and is involved in protein-nucleic acid and protein-protein interactions. [provided by RefSeq, Jul 2008]

SLU7 Products (7)

mRNA	Protein	Name
NM_001364517.2	NP_001351446.1	pre-mRNA-splicing factor SLU7 isoform a
NM_001364518.2	NP_001351447.1	pre-mRNA-splicing factor SLU7 isoform b
NM_001364520.2	NP_001351449.1	pre-mRNA-splicing factor SLU7 isoform b
NM_001364521.2	NP_001351450.1	pre-mRNA-splicing factor SLU7 isoform b
NM_001364522.2	NP_001351451.1	pre-mRNA-splicing factor SLU7 isoform c
NM_001364523.2	NP_001351452.1	pre-mRNA-splicing factor SLU7 isoform c
NM_006425.5	NP_006416.3	pre-mRNA-splicing factor SLU7 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables pre-mRNA 3'-splice site binding	IDA IDA: Inferred from direct assay	15728250	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables second spliceosomal transesterification activity	IDA IDA: Inferred from direct assay	10197984	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	15181151	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in RNA splicing, via transesterification reactions	IDA IDA: Inferred from direct assay	10197984	GOA
involved in alternative mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	15728250	GOA
involved in cellular response to heat	IDA IDA: Inferred from direct assay	21122810	GOA
involved in intracellular protein transport	IDA IDA: Inferred from direct assay	21122810	GOA
involved in mRNA 3'-splice site recognition	IDA IDA: Inferred from direct assay	15728250	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
part of catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	11991638	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	21122810	GOA
located in nuclear speck	IDA IDA: Inferred from direct assay	15728250	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21122810	GOA
part of small nuclear ribonucleoprotein complex	IDA IDA: Inferred from direct assay	15181151	GOA
part of spliceosomal complex	IDA IDA: Inferred from direct assay	10197984	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLU7 Protein Structure

Slu7

0
100
200
300
400
500
586 a.a.

Protein Preferred Names	Protein Names
pre-mRNA-splicing factor SLU7	SLU7 splicing factor homolog

SLU7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	SLU7	O95391	KRT40	Homo sapiens	Q6A162	Y2H Array	25416956
Intra	SLU7	O95391	KRT40	Homo sapiens	Q6A162	Validated Y2H	25416956
Intra	SLU7	O95391	NFKBID	Homo sapiens	Q8NI38	Validated Y2H	32296183
Intra	SLU7	O95391	NFKBID	Homo sapiens	Q8NI38	Y2H Array	32296183
Intra	SLU7	O95391	NFKBID	Homo sapiens	Q8NI38	Y2H Prey Pooling	32296183
Intra	SLU7	O95391	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	SLU7	O95391	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	SLU7	O95391	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	SLU7	O95391	TEPSIN	Homo sapiens	Q96N21	Validated Y2H	32296183
Intra	SLU7	O95391	TEPSIN	Homo sapiens	Q96N21	Y2H Array	32296183
Intra	SLU7	O95391	TEPSIN	Homo sapiens	Q96N21	Y2H Prey Pooling	32296183
Intra	SLU7	O95391	PIBF1	Homo sapiens	Q4G0R1	Y2H Prey Pooling	32296183
Intra	SLU7	O95391	PIBF1	Homo sapiens	Q4G0R1	Validated Y2H	32296183
Intra	SLU7	O95391	PIBF1	Homo sapiens	Q4G0R1	Y2H Array	32296183
Intra	SLU7	O95391	LONRF1	Homo sapiens	Q17RB8	Validated Y2H	32296183
Intra	SLU7	O95391	MCC	Homo sapiens	P23508	Validated Y2H	32296183
Intra	SLU7	O95391	MCC	Homo sapiens	P23508	Y2H Array	32296183
Intra	SLU7	O95391	MCC	Homo sapiens	P23508	Y2H Prey Pooling	32296183
Intra	SLU7	O95391	NSD3	Homo sapiens	Q9BZ95	Anti Tag CoIP	23455924
Intra	SLU7	O95391	NSD3	Homo sapiens	Q9BZ95	Y2H	23455924
Intra	SLU7	O95391	PRPF8	Homo sapiens	Q6P2Q9	Anti Tag CoIP	22365833
Intra	SLU7	O95391	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	SLU7	O95391	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	SLU7	O95391	GOLGA2	Homo sapiens	Q08379	Validated Y2H	32296183
Intra	SLU7	O95391	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	25416956
Intra	SLU7	O95391	ATXN10	Homo sapiens	Q9UBB4	Y2H Array	32814053
Intra	SLU7	O95391	ATXN10	Homo sapiens	Q9UBB4	Y2H Pooling	32814053
Intra	SLU7	O95391	ATXN10	Homo sapiens	Q9UBB4	Validated Y2H	32814053
Intra	SLU7	O95391	NDUFV2	Homo sapiens	P19404	Validated Y2H	32814053
Intra	SLU7	O95391	NDUFV2	Homo sapiens	P19404	Y2H Array	32814053
Intra	SLU7	O95391	NDUFV2	Homo sapiens	P19404	Y2H Pooling	32814053
Intra	SLU7	O95391	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	25416956
Intra	SLU7	O95391	LZTS2	Homo sapiens	Q9BRK4	Validated Y2H	25416956
Intra	SLU7	O95391	FHL3	Homo sapiens	Q13643	Y2H Array	32296183
Intra	SLU7	O95391	FHL3	Homo sapiens	Q13643	Validated Y2H	32296183
Intra	SLU7	O95391	FHL3	Homo sapiens	Q13643	Y2H Prey Pooling	32296183
Intra	SLU7	O95391	THAP1	Homo sapiens	Q9NVV9	Y2H Array	25416956
Intra	SLU7	O95391	GFAP	Homo sapiens	P14136	Validated Y2H	32814053
Intra	SLU7	O95391	GFAP	Homo sapiens	P14136	Y2H Pooling	32814053
Intra	SLU7	O95391	GFAP	Homo sapiens	P14136	Y2H Array	32814053
Intra	SLU7	O95391	AIMP2	Homo sapiens	Q13155	Y2H Array	32296183
Intra	SLU7	O95391	AIMP2	Homo sapiens	Q13155	Y2H Prey Pooling	32296183
Intra	SLU7	O95391	AIMP2	Homo sapiens	Q13155	Validated Y2H	32296183
Intra	SLU7	O95391	DEF6	Homo sapiens	Q9H4E7	Validated Y2H	32296183
Intra	SLU7	O95391	SF3B2	Homo sapiens	Q13435	Y2H	22365833
Intra	SLU7	O95391	PPIL3	Homo sapiens	Q9H2H8	Y2H Prey Pooling	25416956
Intra	SLU7	O95391	PPIL3	Homo sapiens	Q9H2H8	Y2H Array	25416956
Intra	SLU7	O95391	PPIL3	Homo sapiens	Q9H2H8	Y2H Pooling	16189514
Intra	SLU7	O95391	IKBKG	Homo sapiens	Q9Y6K9	Y2H Array	32296183
Intra	SLU7	O95391	IKBKG	Homo sapiens	Q9Y6K9	Y2H Prey Pooling	32296183
Intra	SLU7	O95391	IKBKG	Homo sapiens	Q9Y6K9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Alcoholic Gastritis	Alcoholic Gastritis, With Hemorrhage Alcoholic Gastritis, Without Mention Of Hemorrhage Alcohol Gastritis Etoh Gastritis
Non-Syndromic X-Linked Intellectual Disability	X-Linked Non-Syndromic Intellectual Disability Non-Specific X-Linked Mental Retardation X-Linked Non-Specific Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS13384	SLU7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22327	Slu7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28849	Slu7 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SLU7	MGD	MGI:2385598
Canis familiaris	SLU7	VGNC	VGNC:46515
Bos taurus	SLU7	VGNC	VGNC:34971
Macaca mulatta	SLU7	VGNC	VGNC:77728
Felis catus	SLU7	VGNC	VGNC:65457
Rattus norvegicus	SLU7	RGD	RGD:631432
Others	SLU7	NCBI