PPIL3 - peptidylprolyl isomerase like 3 Gene

Also Known as CYPJ

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 53938

About PPIL3

Cytogenetic location: 2q33.1 Genomic coordinates (GRCh38): 2:200,870,907-200,889,291 (from NCBI)

This gene has 15 transcripts (splice variants), 129 orthologues and 22 paralogues. Ubiquitous expression in lymph node (RPKM 8.6), ovary (RPKM 7.0) and 25 other tissues.

Summary

This gene encodes a member of the Cyclophilin family. Cyclophilins catalyze the cis-trans isomerization of peptidylprolyl imide bonds in oligopeptides. They have been proposed to act either as catalysts or as molecular chaperones in protein-folding events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2008]

PPIL3 Products (2)

mRNA Protein Name
NM_032472.4 NP_115861.1 peptidyl-prolyl cis-trans isomerase-like 3 isoform PPIL3a
NM_130906.3 NP_570981.1 peptidyl-prolyl cis-trans isomerase-like 3 isoform PPIL3b

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Cellular Component GO Annotation Evidence Verweise Source
part of catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
11991638 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPIL3 Protein Structure

Pro_isomerase

Pro_isomerase: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD (3 - 153)

  • 0
  • 100
  • 161 a.a.
Protein Preferred Names Protein Names

peptidyl-prolyl cis-trans isomerase-like 3

  • PPIase

PPIL3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
PPIL3 Q9H2H8 CENATAC Homo sapiens Q86UT8
Y2H Prey Pooling
32296183
Intra
PPIL3 Q9H2H8 CENATAC Homo sapiens Q86UT8
Y2H Array
32296183
Intra
PPIL3 Q9H2H8 SLU7 Homo sapiens O95391
Anti Tag CoIP
33961781
Intra
PPIL3 Q9H2H8 SLU7 Homo sapiens O95391
Y2H
22365833
Intra
PPIL3 Q9H2H8 SLU7 Homo sapiens O95391
Validated Y2H
25416956
Cross
PPIL3 Q9H2H8 VP3 Chicken anemia virus Q99152
Pull Down
18474220
Cross
PPIL3 Q9H2H8 VP3 Chicken anemia virus Q99152
Y2H
18474220
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Estrogen-Receptor Negative Breast Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS10956 PPIL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PPIL3 VGNC VGNC:103061
Mus musculus PPIL3 MGD MGI:1917475
Macaca mulatta PPIL3 VGNC VGNC:82208
Rattus norvegicus PPIL3 RGD RGD:631415
Bos taurus PPIL3 VGNC VGNC:33203
Others PPIL3 NCBI