Actb - actin, beta Gene

Also Known as Actx; beta-actin; E430023M04Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11461

Summary

This gene encodes a member of the actin family of proteins. Actins are highly conserved proteins that are among the most abundant proteins in eukaryotic cells and are involved in cell motility, structure, and integrity. Localization, stability, and translation of the transcribed mRNA are regulated through the binding of multiple factors to its 3' UTR sequence. Homozygous knockout mice for this gene exhibit embryonic lethality. Numerous pseudogenes of this gene have been identified in the mouse genome. [provided by RefSeq, Sep 2015]

Actb Products (1)

mRNA Protein Name
NM_007393.5 NP_031419.1 actin, cytoplasmic 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
10683146 MGI
Biological Process GO Annotation Evidence Verweise Source
involved in negative regulation of protein binding IDA
IDA: Inferred from direct assay
19118186 MGI
involved in regulation of synaptic vesicle endocytosis IDA
IDA: Inferred from direct assay
27840001 MGI
involved in regulation of synaptic vesicle endocytosis IMP
IMP: Inferred from mutant phenotype
27840001 MGI
Cellular Component GO Annotation Evidence Verweise Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
27840001 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
27840001 MGI
located in brush border IDA
IDA: Inferred from direct assay
33129760 MGI
is active in calyx of Held IDA
IDA: Inferred from direct assay
27840001 MGI
is active in calyx of Held IMP
IMP: Inferred from mutant phenotype
27840001 MGI
located in cortical cytoskeleton IDA
IDA: Inferred from direct assay
18723693 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
24327345 MGI
located in cytoskeleton IDA
IDA: Inferred from direct assay
24327345 MGI
located in cytosol IDA
IDA: Inferred from direct assay
11931770 MGI
located in nucleus IDA
IDA: Inferred from direct assay
29042633 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

actin, cytoplasmic 1

  • A-X actin-like protein

  • actin, beta, cytoplasmic

  • melanoma X-actin

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-16025 EOC317 Inhibitor 98.01% Phase 1

Pre-clinical Phase

Bioactive Molecules (8)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-184235 β-actin-IN-1 Inhibitor / Unkown
HY-N19906 Psoralenol Inhibitor / Unkown
HY-RS00215 ACTB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10891 POTEF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-185838 FAM-labeled Human beta-actin siRNA / Unkown
HY-185838A Cy3-labeled Human beta-actin siRNA / Unkown
HY-RS17630 Actb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24090 Actb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Actb NCBI NCBI:60