Gfap - glial fibrillary acidic protein Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14580

Summary

A structural constituent of Cytoskeleton. Involved in regulation of chaperone-mediated Autophagy. Acts upstream of or within with a positive effect on D-aspartate import across plasma membrane; gene expression; and intracellular protein transport. Acts upstream of or within several processes, including intermediate filament organization; long-term synaptic potentiation; and neurogenesis. Located in several cellular components, including astrocyte end-foot; cell body; and intermediate filament. Is expressed in several structures, including alimentary system; hemolymphoid system; integumental system; nervous system; and sensory organ. Used to study Alexander disease. Human ortholog(s) of this gene implicated in Alexander disease. Orthologous to human GFAP (glial fibrillary acidic protein). [provided by Alliance of Genome Resources, Apr 2022]

Gfap Products (2)

mRNA Protein Name
NM_001131020.1 NP_001124492.1 glial fibrillary acidic protein isoform 1
NM_010277.3 NP_034407.2 glial fibrillary acidic protein isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
12403814 MGI
enables structural constituent of cytoskeleton IMP
IMP: Inferred from mutant phenotype
12177195 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within Bergmann glial cell differentiation IMP
IMP: Inferred from mutant phenotype
10816608 MGI
acts upstream of or within positive effect D-aspartate import across plasma membrane IMP
IMP: Inferred from mutant phenotype
15135219 MGI
acts upstream of Schwann cell proliferation IMP
IMP: Inferred from mutant phenotype
16988027 MGI
acts upstream of or within astrocyte development IGI
IGI: Inferred from genetic interaction
11487638 MGI
acts upstream of or within extracellular matrix organization IMP
IMP: Inferred from mutant phenotype
11487638 MGI
acts upstream of or within positive effect gene expression IMP
IMP: Inferred from mutant phenotype
15135219 MGI
acts upstream of or within intermediate filament organization IGI
IGI: Inferred from genetic interaction
11487638 MGI
acts upstream of or within intermediate filament organization IMP
IMP: Inferred from mutant phenotype
8692820 MGI
acts upstream of or within intermediate filament-based process IMP
IMP: Inferred from mutant phenotype
12177195 MGI
acts upstream of or within positive effect intracellular protein transport IMP
IMP: Inferred from mutant phenotype
15135219 MGI
acts upstream of or within long-term synaptic potentiation IMP
IMP: Inferred from mutant phenotype
8692820 MGI
acts upstream of or within negative regulation of neuron projection development IGI
IGI: Inferred from genetic interaction
11487638 MGI
acts upstream of or within negative regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
11487638 MGI
acts upstream of neuron projection development IGI
IGI: Inferred from genetic interaction
11487638 MGI
acts upstream of neuron projection development IMP
IMP: Inferred from mutant phenotype
11487638 MGI
acts upstream of or within neuron projection regeneration IMP
IMP: Inferred from mutant phenotype
16988027 MGI
acts upstream of or within positive regulation of Schwann cell proliferation IMP
IMP: Inferred from mutant phenotype
16988027 MGI
involved in regulation of chaperone-mediated autophagy IMP
IMP: Inferred from mutant phenotype
20797626 MGI
acts upstream of or within regulation of neurotransmitter uptake IMP
IMP: Inferred from mutant phenotype
15135219 MGI
Cellular Component GO Annotation Evidence Verweise Source
located in astrocyte end-foot IDA
IDA: Inferred from direct assay
21212183 MGI
located in astrocyte projection IDA
IDA: Inferred from direct assay
19646951 MGI
located in cell body IDA
IDA: Inferred from direct assay
8793730 MGI
located in cell projection IDA
IDA: Inferred from direct assay
10989258 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
11064363 MGI
located in cytoskeleton IDA
IDA: Inferred from direct assay
29350434 MGI
located in glial cell projection IDA
IDA: Inferred from direct assay
20531390 MGI
located in intermediate filament IDA
IDA: Inferred from direct assay
9364068 MGI
located in membrane IDA
IDA: Inferred from direct assay
11283023 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glial fibrillary acidic protein

  • intermediate filament protein

Recombinant Gfap Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P72203 GFAP Protein, Mouse (His-SUMO) P03995 (M1-M430) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-P3392A Zilganersen sodium Inhibitor 91.43% Phase 3

Pre-clinical Phase

Bioactive Molecules (13)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-148013 K284-6111 Inhibitor 99.94% Unkown
HY-W035091 Tetrachloroauric acid 97.0% Unkown
HY-W019710 (E,E)-RGFP966 Inhibitor 99.44% Unkown
HY-N6908 Continentalic acid 99.72% Unkown
HY-176311S GFAP, U-15N / Unkown
HY-181178 (Mor-Cor)Ag(III) Inhibitor / Unkown
HY-183796 GFAP/NF-κB/APOE/NLRP3-IN-1 Inhibitor / Unkown
HY-184108 ZL006-05 / Unkown
HY-187301S [U-15N]-GFAP / Unkown
HY-P3392 Zilganersen 91.43% Unkown
HY-RS05376 GFAP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17035 Gfap Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23479 Gfap Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gfap NCBI NCBI:2670