DYRK1A - dual specificity tyrosine phosphorylation regulated kinase 1A Gene

Also Known as MNB; DYRK; HP86; MNBH; MRD7; DYRK1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1859

About DYRK1A

Cytogenetic location: 21q22.13 Genomic coordinates (GRCh38): 21:37,365,573-37,526,358 (from NCBI)

This gene has 23 transcripts (splice variants), 236 orthologues, 12 paralogues and is associated with 4 phenotypes. Ubiquitous expression in bone marrow (RPKM 11.6), testis (RPKM 9.5) and 25 other tissues.

Summary

This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat DYRK gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each Other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008]

DYRK1A Products (18)

mRNA	Protein	Name
XM_005260933.6	XP_005260990.1	dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X5
XM_006723977.4	XP_006724040.1	dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X2
NM_001396.5	NP_001387.2	dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 1
XM_024452057.2	XP_024307825.1	dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X4
XM_047440704.1	XP_047296660.1	dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X1
NM_130436.2	NP_569120.1	dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 2
XM_047440701.1	XP_047296657.1	dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X1
NM_101395.2	NP_567824.1	dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 3
XM_047440702.1	XP_047296658.1	dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X1
XM_047440706.1	XP_047296662.1	dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X3
XM_047440703.1	XP_047296659.1	dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X1
NM_001347723.2	NP_001334652.1	dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 6
NM_130437.2
NM_001347721.2	NP_001334650.1	dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 2
XM_047440705.1	XP_047296661.1	dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X1
NM_001347722.2	NP_001334651.1	dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 2
NM_130438.2	NP_569122.1	dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 5
XM_047440700.1	XP_047296656.1	dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables RNA polymerase II CTD heptapeptide repeat kinase activity	IDA IDA: Inferred from direct assay	25620562	GOA
enables actin binding	IPI IPI: Inferred from physical interaction	24327345	GOA
enables cytoskeletal protein binding	IPI IPI: Inferred from physical interaction	24327345	GOA
enables histone H3T45 kinase activity	IDA IDA: Inferred from direct assay	24820035	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	23665168	GOA
enables non-membrane spanning protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	9748265	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14500717	GOA
enables protein serine kinase activity	IDA IDA: Inferred from direct assay	30773093	GOA
enables protein serine/threonine kinase activity	IGI IGI: Inferred from genetic interaction	17906291	GOA
enables tubulin binding	IPI IPI: Inferred from physical interaction	24327345	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in amyloid-beta formation	IMP IMP: Inferred from mutant phenotype	25556849	GOA
involved in negative regulation of DNA methylation-dependent heterochromatin formation	IDA IDA: Inferred from direct assay	24820035	GOA
involved in peptidyl-serine phosphorylation	IGI IGI: Inferred from genetic interaction	25556849	GOA
involved in peptidyl-tyrosine autophosphorylation	IDA IDA: Inferred from direct assay	24327345	GOA
acts upstream of or within peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	9748265	GOA
involved in positive regulation of RNA splicing	IDA IDA: Inferred from direct assay	28377597	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
colocalizes with actin filament	IPI IPI: Inferred from physical interaction	24327345	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	15694837	GOA
colocalizes with cytoskeleton	IDA IDA: Inferred from direct assay	24327345	GOA
colocalizes with microtubule	IPI IPI: Inferred from physical interaction	24327345	GOA
colocalizes with neurofilament	IPI IPI: Inferred from physical interaction	24327345	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	25620562	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15694837	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DYRK1A Protein Structure

Pkinase

0
200
400
600
763 a.a.

Protein Preferred Names	Protein Names
dual specificity tyrosine-phosphorylation-regulated kinase 1A	MNB/DYRK protein kinase dual specificity YAK1-related kinase dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A mnb protein kinase homolog hp86 protein kinase minibrain homolog serine/threonine kinase MNB serine/threonine-specific protein kinase

DYRK1A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	DYRK1A	Q13627	IGF2BP2	Homo sapiens	Q9Y6M1	Anti Bait CoIP	36950384
Intra	DYRK1A	Q13627	IGF2BP1	Homo sapiens	Q9NZI8	Anti Bait CoIP	36950384
Intra	DYRK1A	Q13627	IGF2BP3	Homo sapiens	O00425	Anti Bait CoIP	36950384
Intra	DYRK1A	Q13627	KPRP	Homo sapiens	Q5T749	Validated Y2H	32296183
Intra	DYRK1A	Q13627	ELAVL2	Homo sapiens	Q12926	Anti Bait CoIP	36950384
Intra	DYRK1A	Q13627	FAM53C	Homo sapiens	Q9NYF3	Anti Bait CoIP	36950384
Intra	DYRK1A	Q13627	FAM53C	Homo sapiens	Q9NYF3	Y2H Fragment Pooling	35914814
Intra	DYRK1A	Q13627	FAM53C	Homo sapiens	Q9NYF3	TAP	23602568
Intra	DYRK1A	Q13627	TROAP	Homo sapiens	Q12815	TAP	23602568
Intra	DYRK1A	Q13627	TROAP	Homo sapiens	Q12815	Crosslink	26949739
Intra	DYRK1A	Q13627	TRIP12	Homo sapiens	Q14669	Anti Bait CoIP	36950384
Intra	DYRK1A	Q13627	DYNLL1	Homo sapiens	P63167	Y2H Fragment Pooling	35914814
Intra	DYRK1A	Q13627	DYNLL1	Homo sapiens	P63167	TAP	23602568
Intra	DYRK1A	Q13627	DYNLL1	Homo sapiens	P63167	Anti Bait CoIP	36950384
Intra	DYRK1A	Q13627	TRAF2	Homo sapiens	Q12933	Y2H Fragment Pooling	35914814
Intra	DYRK1A	Q13627	DCAF7	Homo sapiens	P61962	Pull Down	32707033
Intra	DYRK1A	Q13627	DCAF7	Homo sapiens	P61962	TAP	23602568
Intra	DYRK1A	Q13627	DCAF7	Homo sapiens	P61962	Anti Bait CoIP	36950384
Intra	DYRK1A	Q13627	FMR1	Homo sapiens	Q06787	Anti Bait CoIP	36950384
Intra	DYRK1A	Q13627	RB1	Homo sapiens	P06400	BiFC	23602568
Intra	DYRK1A	Q13627	RB1	Homo sapiens	P06400	Pull Down	32707033
Intra	DYRK1A	Q13627	RB1	Homo sapiens	P06400	TAP	23602568
Intra	DYRK1A	Q13627	LZTS2	Homo sapiens	Q9BRK4	Crosslink	26949739
Intra	DYRK1A	Q13627	LZTS2	Homo sapiens	Q9BRK4	TAP	23602568
Intra	DYRK1A	Q13627	LZTS2	Homo sapiens	Q9BRK4	BiFC	23602568
Intra	DYRK1A	Q13627	SATB1	Homo sapiens	Q01826	Anti Bait CoIP	36950384
Intra	DYRK1A	Q13627	ELAVL3	Homo sapiens	Q14576	Anti Bait CoIP	36950384
Intra	DYRK1A	Q13627	ZMYND8	Homo sapiens	Q9ULU4	Anti Bait CoIP	36950384
Intra	DYRK1A	Q13627	USP54	Homo sapiens	Q70EL1	Y2H Fragment Pooling	35914814
Intra	DYRK1A	Q13627	RBL1	Homo sapiens	P28749	Pull Down	32707033
Intra	DYRK1A	Q13627	RBL1	Homo sapiens	P28749	TAP	23602568
Intra	DYRK1A	Q13627	RBL1	Homo sapiens	P28749	Anti Tag CoIP	23602568

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Intellectual Developmental Disorder, Autosomal Dominant 7	MRD7 Mental Retardation, Autosomal Dominant 7 Autosomal Dominant Non-Syndromic Intellectual Disability 7 Dyrk1a Syndrome Autosomal Dominant Intellectual Developmental Disorder 7 Autosomal Dominant Mental Retardation 7 Mental Retardation, Autosomal Dominant, Type 7
Autosomal Dominant Intellectual Developmental Disorder	Autosomal Dominant Mental Retardation Autosomal Dominant Non-Syndromic Mental Retardation Autosomal Dominant Non-Syndromic Intellectual Disability Mental Retardation, Autosomal Dominant
Non-Specific Syndromic Intellectual Disability	Complex Neurodevelopmental Disorder
Primary Microcephaly	True Microcephaly Microcephaly, Primary
Chromosomal Duplication Syndrome
Myeloproliferative Syndrome, Transient	Transient Abnormal Myelopoiesis Transient Myeloproliferative Syndrome Transient Myeloproliferative Disease Mst Tam Leukemia, Transient, Of Down Syndrome Tmd Leukemia, Transient Transient Leukemia Transient Leukemia Of Down Syndrome
Acute Dacryocystitis	Dacryocystitis - Acute
Dyrk1a-Related Intellectual Disability Syndrome Due To 21q22.13q22.2 Microdeletion	21q22.13q22.2 Microdeletion Syndrome Del(21)(Q22.13q22.2) Monosomy 21q22.13q22.2
Specific Developmental Disorder
Enophthalmos
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Abdominal Obesity-Metabolic Syndrome 3	AOMS3 Central Obesity, Type 2 Diabetes, Hypertension, And Early-Onset Coronary Artery Disease Obesity, Abdominal, Metabolic Syndrome, Type 3
Chromosomal Disease	Chromosomal Disorders Congenital Chromosomal Disease
Pick Disease Of Brain	Pick Disease Pick Disease Of The Brain Lobar Atrophy Of Brain Dementia With Lobar Atrophy And Neuronal Cytoplasmic Inclusions Pick'S Disease Behavioral Variant Of Frontotemporal Dementia Dementia In Pick'S Disease Lobar Atrophy Of The Brain Bvftd Bv-Ftd PIDB Picks Disease
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Male Urethral Cancer	Male Urethral Malignant Neoplasm
Dyrk1a-Related Intellectual Disability Syndrome	Dyrk1a Syndrome
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder
Microphthalmia	Microphthalmos Isolated Anophthalmia-Microphthalmia Syndrome Isolated Microphthalmia-Anophthalmia-Coloboma Simple Microphthalmos Clinical Anophthalmia Isolated Anophthalmia - Microphthalmia Isolated Pure Microphthalmia Mac Spectrum Microphthalmia-Anophthalmia-Coloboma Spectrum Primitive Anophthalmia Globe Of Eye Small Small Eyeball Hypoplasia Of Eye Isolated Nanophthalmos Rudimentary Eye Dysplasia Of Eye
Down Syndrome	Trisomy 21 Complete Trisomy 21 Syndrome Down'S Syndrome Trisomy 21 Syndrome Down'S Syndrome - Trisomy 21 Downs Syndrome G Trisomy 47,Xx,+21 47,Xy,+21 Trisomy G Down Syndrome, Susceptibility To Chromosome 21 Trisomy Trisomy 21 Nos Abnormal Autosomes 21
Intellectual Disability Syndrome Due To A Dyrk1a Point Mutation	Dyrk1a-Related Intellectual Disability Syndrome Due To A Point Mutation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-X0009	Tambiciclib		99.68%	Phase 2
HY-X0009A	Tambiciclib dimaleate		99.53%	Phase 2

Pre-clinical Phase

Bioactive Molecules (82)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-142295	GNF2133	Inhibitor	99.67%	Unkown
HY-115470	CLK-IN-T3	Inhibitor	99.78%	Unkown
HY-129492	GNF4877	Inhibitor	99.82%	Unkown
HY-105309	GSK-626616	Inhibitor	99.88%	Unkown
HY-101298	Paprotrain	Inhibitor	99.85%	Unkown
HY-108476	INDY	Inhibitor	99.32%	Unkown
HY-112296	T025		99.64%	Unkown
HY-15569	NU6102	Inhibitor	99.23%	Unkown
HY-15951	ML167	Inhibitor	98.62%	Unkown
HY-111380	EHT 1610	Inhibitor	98.93%	Unkown
HY-132308	DYRK1-IN-1	Inhibitor	99.71%	Unkown
HY-12838	RO5454948	Inhibitor	99.53%	Unkown
HY-101029	MBM-55		99.94%	Unkown
HY-155723	Leucettinib-92	Inhibitor	98.54%	Unkown
HY-146221	Dyrk1A-IN-5	Inhibitor	98.06%	Unkown
HY-144290	ARN25068	Inhibitor	98.19%	Unkown
HY-135906	CK2/ERK8-IN-1		99.0%	Unkown
HY-P5430	DYRKtide		98.59%	Unkown
HY-147060	Dyrk1A-IN-3	Inhibitor	99.68%	Unkown
HY-147066	Dyrk1A-IN-4	Inhibitor	99.30%	Unkown
HY-111379	EHT 5372	Inhibitor	98.12%	Unkown
HY-110052	TBCA	Inhibitor	99.45%	Unkown
HY-34222	7-Deazaguanine	Inhibitor	99.73%	Unkown
HY-149262	CLK1-IN-3		98.54%	Unkown
HY-142295A	GNF2133 hydrochloride	Inhibitor	99.86%	Unkown
HY-156816	ON 108600	Inhibitor	98.65%	Unkown
HY-128758A	DYRKs-IN-1 hydrochloride	Inhibitor	98.29%	Unkown
HY-12828A	KH-CB20	Inhibitor	99.80%	Unkown
HY-176723	RD0392	Inhibitor	99.93%	Unkown
HY-148105	DS12881479		99.63%	Unkown
HY-RS04095	Dyrk1a Mouse Pre-designed siRNA Set A		/	Unkown
HY-128758	DYRKs-IN-1	Inhibitor	/	Unkown
HY-176402	Dyrk1A-IN-13	Inhibitor	99.43%	Unkown
HY-179177	AO-365/43472821	Inhibitor	99.94%	Unkown
HY-402805	DYRK2-IN-2	Inhibitor	/	Unkown
HY-402805A	DYRK2-IN-2 hydrochloride	Inhibitor	/	Unkown
HY-N12625	(R)-(+)-O-Demethylbuchenavianine	Inhibitor	98.67%	Unkown
HY-101029A	MBM-55S		/	Unkown
HY-122670	VS-II-173		/	Unkown
HY-125288	DS42450411	Inhibitor	/	Unkown
HY-128759	DYRKs-IN-2	Inhibitor	/	Unkown
HY-129449	AnnH31	Inhibitor	99.91%	Unkown
HY-139830	Dyrk1A-IN-1	Inhibitor	/	Unkown
HY-144614	JH-XVII-10		/	Unkown
HY-144617	JH-XIV-68-3	Inhibitor	/	Unkown
HY-144695	Dyrk1A/α-synuclein-IN-1	Inhibitor	/	Unkown
HY-144696	Dyrk1A/α-synuclein-IN-2	Inhibitor	/	Unkown
HY-144826	ZDWX-25	Inhibitor	/	Unkown
HY-146337	Dyrk1A/B-IN-1	Inhibitor	/	Unkown
HY-146586	Haspin-IN-1	Inhibitor	/	Unkown
HY-146587	Haspin-IN-2	Inhibitor	/	Unkown
HY-150537	AChE/GSK-3β-IN-1	Inhibitor	/	Unkown
HY-152183	FINDY	Inhibitor	/	Unkown
HY-157995	Dyrk1A-IN-7	Inhibitor	/	Unkown
HY-158212	Dyrk1A-IN-8	Inhibitor	/	Unkown
HY-159496	Dyrk1A-IN-10	Inhibitor	/	Unkown
HY-163514	hAChE-IN-8	Inhibitor	/	Unkown
HY-173615	KTD-092	Inhibitor	/	Unkown
HY-179538	CSH-4044	Inhibitor	/	Unkown
HY-179599	Dyrk1A-IN-15	Inhibitor	/	Unkown
HY-179600	Dyrk1A-IN-16	Inhibitor	/	Unkown
HY-180817	CDK2-IN-55		98.91%	Unkown
HY-183584	ARN25699		/	Unkown
HY-184276	CLK1-IN-5	Inhibitor	/	Unkown
HY-N17356	Atalaphyllidine	Inhibitor	/	Unkown
HY-N2892	Aristolactam A IIIa	Inhibitor	/	Unkown
HY-P3992	5-FAM-Dyrktide		/	Unkown
HY-RS04094	DYRK1A Human Pre-designed siRNA Set A		/	Unkown
HY-RS04096	Dyrk1a Rat Pre-designed siRNA Set A		/	Unkown
HY-W409652	CLK1/4-IN-2	Inhibitor	/	Unkown
HY-108475	ProINDY	Inhibitor	/	Unkown
HY-122989	Aristolactam BIII	Inhibitor	/	Unkown
HY-147760	Dyrk1A-IN-2	Inhibitor	/	Unkown
HY-162107	Dyrk1A-IN-6	Inhibitor	/	Unkown
HY-162597	Dyrk1A-IN-9	Inhibitor	/	Unkown
HY-168265	Dyrk1A-IN-11	Inhibitor	/	Unkown
HY-170940	Dyrk1A-IN-12	Inhibitor	/	Unkown
HY-181046	Multi-kinase-IN-14		/	Unkown
HY-181085	RD0448	Inhibitor	/	Unkown
HY-183955	GNF7156	Inhibitor	/	Unkown
HY-77324S	4-(Trifluoromethyl)aniline-d4	Inhibitor	99.23%	Unkown
HY-W067583	Norharmine	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DYRK1A	MGD	MGI:1330299
Bos taurus	DYRK1A	VGNC	VGNC:28279
Macaca mulatta	DYRK1A	VGNC	VGNC:72015
Canis familiaris	DYRK1A	VGNC	VGNC:40155
Rattus norvegicus	DYRK1A	RGD	RGD:2528
Felis catus	DYRK1A	VGNC	VGNC:61685
Others	DYRK1A	NCBI