USP54 - ubiquitin specific peptidase 54 Gene

Also Known as C10orf29; bA137L10.3; bA137L10.4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 159195

About USP54

This gene has 25 transcripts (splice variants), 205 orthologues and 1 paralogue. Broad expression in thyroid (RPKM 13.4), brain (RPKM 8.5) and 22 other tissues.

Summary

Predicted to enable thiol-dependent Deubiquitinase. Predicted to be involved in protein deubiquitination. [provided by Alliance of Genome Resources, Apr 2022]

USP54 Products (21)

mRNA Protein Name
NM_001320437.2 NP_001307366.1 inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 2
NM_001320441.2 NP_001307370.1 inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 3
NM_001350995.2 NP_001337924.1 inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 4
NM_001378208.1 NP_001365137.1 inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 5
NM_001378209.1 NP_001365138.1 inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 5
NM_001378210.1 NP_001365139.1 inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 5
NM_001391941.1 NP_001378870.1 inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 6
NM_001391942.1 NP_001378871.1 inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 4
NM_001391945.1 NP_001378874.1 inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 5
NM_001391946.1 NP_001378875.1 inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 5
NM_001391947.1 NP_001378876.1 inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 7
NM_001391948.1 NP_001378877.1 inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 5
NM_001391949.1 NP_001378878.1 inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 8
NM_001391950.1 NP_001378879.1 inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 7
NM_001391951.1 NP_001378880.1 inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 9
NM_001391952.1 NP_001378881.1 inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 8
NM_001391953.1 NP_001378882.1 inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 1
NM_001391954.1 NP_001378883.1 inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 5
NM_001391955.1 NP_001378884.1 inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 5
NM_001391956.1 NP_001378885.1 inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 1
NM_152586.4 NP_689799.3 inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables cysteine-type deubiquitinase activity IDA
IDA: Inferred from direct assay
36590171 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16713569 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP54 Protein Structure

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (39 - 349)

  • 0
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  • 1200
  • 1500
  • 1684 a.a.
Protein Preferred Names Protein Names

inactive ubiquitin carboxyl-terminal hydrolase 54

  • inactive ubiquitin-specific peptidase 54

USP54 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
USP54 Q70EL1 DYRK1A Homo sapiens Q13627
Anti Tag CoIP
33961781
Cross
USP54 Q70EL1 P0DTD1-PRO_0000449629 SARS-CoV-2 P0DTD1-PRO_0000449629
Y2H Array
36217030
Intra
USP54 Q70EL1 ATXN1 Homo sapiens P54253
Y2H
16713569
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15565 USP54 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22905 Usp54 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29419 Usp54 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus USP54 RGD RGD:1303206
Canis familiaris USP54 VGNC VGNC:48203
Bos taurus USP54 VGNC VGNC:36736
Macaca mulatta USP54 VGNC VGNC:106116
Felis catus USP54 VGNC VGNC:66896
Mus musculus USP54 MGD MGI:1926037
Others USP54 NCBI