IRF5 - interferon regulatory factor 5 Gene

Also Known as SLEB10

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3663

About IRF5

Cytogenetic location: 7q32.1 Genomic coordinates (GRCh38): 7:128,937,032-128,950,038 (from NCBI)

This gene has 22 transcripts (splice variants), 218 orthologues, 8 paralogues and is associated with 8 phenotypes. Broad expression in spleen (RPKM 8.6), lymph node (RPKM 6.5) and 25 other tissues.

Summary

This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, Apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Alternative promoter use and alternative splicing result in multiple transcript variants, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. [provided by RefSeq, Dec 2016]

IRF5 Products (7)

mRNA	Protein	Name
NM_001098627.4	NP_001092097.2	interferon regulatory factor 5 isoform b
NM_001098629.3	NP_001092099.1	interferon regulatory factor 5 isoform d
NM_001098630.3	NP_001092100.1	interferon regulatory factor 5 isoform b
NM_001242452.3	NP_001229381.1	interferon regulatory factor 5 isoform e
NM_001347928.2	NP_001334857.1	interferon regulatory factor 5 isoform d
NM_001364314.2	NP_001351243.1	interferon regulatory factor 5 isoform d
NM_032643.5	NP_116032.1	interferon regulatory factor 5 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	12600985	GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	25326418	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	18836453	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18836453	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	25326418	GOA
enables sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	23332764	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in cellular response to virus	IDA IDA: Inferred from direct assay	29046356	GOA
involved in cytokine-mediated signaling pathway	IDA IDA: Inferred from direct assay	25326418	GOA
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	22412986	GOA
involved in positive regulation of cytokine production involved in immune response	IDA IDA: Inferred from direct assay	29046356	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12600985	GOA
involved in positive regulation of type I interferon production	IDA IDA: Inferred from direct assay	32433612	GOA
involved in response to muramyl dipeptide	IDA IDA: Inferred from direct assay	22412986	GOA
involved in response to peptidoglycan	IDA IDA: Inferred from direct assay	22412986	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	22412986	GOA
located in nucleus	IDA IDA: Inferred from direct assay	22412986	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IRF5 Protein Structure

IRF

IRF-3

0
100
200
300
400
498 a.a.

Protein Preferred Names	Protein Names
interferon regulatory factor 5

IRF5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	IRF5	Q13568	SGTA	Homo sapiens	O43765	Confocal	21988832
Intra	IRF5	Q13568	CEP152	Homo sapiens	O94986	BioID	35140242
Intra	IRF5	Q13568	IRF5	Homo sapiens	Q13568	X-Ray Diffraction	18836453
Intra	IRF5	Q13568	TRIM28	Homo sapiens	Q13263	Crosslink	22995936
Intra	IRF5	Q13568	MAVS	Homo sapiens	Q7Z434	Anti Tag CoIP	21903422
Intra	IRF5	Q13568	IRF5	Homo sapiens	Q13568	GMS	18836453
Intra	IRF5	Q13568	TRIM28	Homo sapiens	Q13263	Anti Tag CoIP	22995936
Intra	IRF5	Q13568	CREBBP	Homo sapiens	Q92793	GMS	18836453
Intra	IRF5	Q13568	RELA	Homo sapiens	Q04206	Anti Bait CoIP	20237317
Intra	IRF5	Q13568	IRF5	Homo sapiens	Q13568	Solution Sedimentation	18836453
Intra	IRF5	Q13568	CEP152	Homo sapiens	O94986	Anti Tag CoIP	21903422
Intra	IRF5	Q13568	CREBBP	Homo sapiens	Q92793	Solution Sedimentation	18836453
Intra	IRF5	Q13568	CREBBP	Homo sapiens	Q92793	ITC	18836453

Cross: Cross-species interaction Intra: Intraspecies interaction

IRF5 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P82139	IRF5 Antibody (YA1884)	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
HY-P82139A	IRF5 Antibody (YA1884)(PBS only)	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Systemic Lupus Erythematosus 10	Systemic Lupus Erythematosus, Susceptibility To, 10 SLEB10 Lupus Erythematosus, Systemic, Type 10
Inflammatory Bowel Disease 14	IBD14 Inflammatory Bowel Disease 14, Susceptibility To Bowel Disease, Inflammatory, Type 14
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Limited Scleroderma	Limited Cutaneous Systemic Sclerosis Limited Systemic Sclerosis Systemic Sclerosis Sine Scleroderma Crest Syndrome Limited Cutaneous Systemic Scleroderma Scleroderma, Limited Systemic Sclerosis, Limited Progressive Systemic Sclerosis Sine Scleroderma Scleroderma, Sine Crest - [Calcinosis, Raynaud Phenomenon, Oesophageal Dysmotility, Sclerodactyly, And Telangiectasia] Syndrome Crst - [Calcinosis, Raynaud Phenomenon, Sclerodactyly And Telangiectasia] Syndrome
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Diffuse Cutaneous Systemic Sclerosis	Diffuse Cutaneous Systemic Scleroderma Progressive Cutaneous Systemic Scleroderma Progressive Cutaneous Systemic Sclerosis Dcssc Diffuse Scleroderma
Primary Biliary Cholangitis	Primary Biliary Cirrhosis Biliary Liver Cirrhosis Chronic Nonsuppurative Destructive Cholangitis Familial Primary Biliary Cirrhosis Pbc Hanot Syndrome Cholestatic Cirrhosis Biliary Cirrhosis Primary Liver Cirrhosis, Biliary Hanot'S Cirrhosis Biliary Cirrhosis Pericholangiolic Biliary Cirrhosis Tannhauser-Magendantz Syndrome Hanot-Rossle Syndrome Hypertrophic Cirrhosis Todd Cirrhosis Hanot Cirrhosis Charcot Cirrhosis Mahon-Tannhauser Syndrome Toxic Cirrhosis Hypertrophic Biliary Cirrhosis Monolobular Cirrhosis Unilobar Cirrhosis Xanthomatous Biliary Cirrhosis
Arthritis	Inflammatory Joint Disease Inflammatory Disorder Of Joint
Lupus Erythematosus	Lupus Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus, Systemic Subacute Cutaneous Lupus Le - [Lupus Erythematosus]
Ulcerative Colitis	Colitis Gravis Left Sided Ulcerative Colitis Left-Sided Ulcerative Colitis Idiopathic Proctocolitis Inflammatory Bowel Disease, Ulcerative Colitis Type Uc Colitis Ulcerative Colitis, Ulcerative Chronic Left-Sided Ulcerative Colitis Uc - [Ulcerative Colitis] Chronic Ulcerative Enteritis Mucosal Proctocolitis Ulcerative Mucosal Proctocolitis Left Hemicolitis
Colitis
Autoimmune Disease	Autoimmune Diseases Autoimmune Hypersensitivity Disease Hypersensitivity Reaction Type Ii Disease Type Ii Hypersensitivity Reaction Disease
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Systemic Scleroderma	Scleroderma Progressive Systemic Sclerosis Systemic Sclerosis Scleroderma, Systemic Scleroderma Syndrome Dermatosclerosis Familial Progressive Scleroderma Progressive Scleroderma Scleroderma Disease Scleroderma, Localized Diffuse Scleroderma Scleroderma, Familial Progressive
Macrophage Activation Syndrome
Autoimmune Disease Of Exocrine System
Chilblain Lupus 1	Chilblain Lupus CHBL1 Chilblain Lupus Erythematosus Chle Hutchinson Lupus Chilblain Lupus, Type 1
Potocki-Shaffer Syndrome	Proximal 11p Deletion Syndrome Chromosome 11p11.2 Deletion Syndrome Pss 11p11.2 Deletion P11pds Defect11 Syndrome Deletion Of Chromosome 11p11.2 POSHS
Cutaneous Lupus Erythematosus	Lupus Erythematosus, Cutaneous Lupus Erythematosus Cutaneous
Uterine Adnexa Cancer
Aicardi-Goutieres Syndrome	Aicardi Goutieres Syndrome Cree Encephalitis Aicardi-Goutières Syndrome Encephalopathy With Basal Ganglia Calcification Ags Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid Pseudotoxoplasmosis Syndrome Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis Aicardi-Goutieres Syndrome 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-146244	Agatolimod		98.84%	Unkown
HY-149652	IRF5-IN-1	Inhibitor	99.91%	Unkown
HY-150095	YE6144	Inhibitor	96.47%	Unkown
HY-175759	EN1033		99.96%	Unkown
HY-P11072	IRF5-CPP5	Inhibitor	99.23%	Unkown
HY-113509B	15(R)-Lipoxin A4		98.3%	Unkown
HY-P11003	PTD-N5-1	Inhibitor	/	Unkown
HY-RS06909	IRF5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-150095A	YE6144 free base	Inhibitor	/	Unkown
HY-RS16837	Irf5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23279	Irf5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-P991956	ABB071	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	IRF5	RGD	RGD:1310447
Macaca mulatta	IRF5	VGNC	VGNC:73763
Canis familiaris	IRF5	VGNC	VGNC:42094
Felis catus	IRF5	VGNC	VGNC:67827
Mus musculus	IRF5	MGD	MGI:1350924
Bos taurus	IRF5	VGNC	VGNC:30276
Others	IRF5	NCBI