PDE1A - phosphodiesterase 1A Gene

Also Known as HCAM1; HCAM-1; HSPDE1A; CAM-PDE 1A; CAM-PDE-1A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5136

About PDE1A

Cytogenetic location: 2q32.1 Genomic coordinates (GRCh38): 2:182,140,041-182,716,797 (from NCBI)

This gene has 8 transcripts (splice variants), 208 orthologues and 20 paralogues. Broad expression in thyroid (RPKM 7.4), brain (RPKM 6.5) and 18 other tissues.

Summary

Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are CA(2+)/Calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by Calmodulin in the presence of CA(2+) (Michibata et al., 2001 [PubMed 11342109]; Fidock et al., 2002 [PubMed 11747989]).[supplied by OMIM, Oct 2009]

PDE1A Products (25)

mRNA Protein Name
NM_001395269.1 NP_001382198.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 11
NM_001395265.2 NP_001382194.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 8
NM_001258313.3 NP_001245242.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 4
XM_017004294.3 XP_016859783.1 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X2
NM_001395259.2 NP_001382188.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 1
NM_001395266.1 NP_001382195.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 9
NM_001258314.3 NP_001245243.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 5
XM_011511324.4 XP_011509626.1 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X3
XM_047444688.1 XP_047300644.1 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X4
XM_011511325.4 XP_011509627.1 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X5
NM_001395260.2 NP_001382189.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 1
NM_001395262.1 NP_001382191.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2
NM_001395267.1 NP_001382196.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 9
NM_005019.7 NP_005010.2 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 1
NM_001395264.1 NP_001382193.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 7
NM_001395268.1 NP_001382197.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 10
NM_001003683.3 NP_001003683.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2
NM_001395261.2 NP_001382190.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 1
NM_001258312.3 NP_001245241.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 3
XM_011511326.3 XP_011509628.1 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X6
XM_011511323.3 XP_011509625.1 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1
XR_007076388.1
NM_001395258.2 NP_001382187.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 1
NM_001395263.1 NP_001382192.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2
NM_001363871.4 NP_001350800.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 6

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity IDA
IDA: Inferred from direct assay
8557689 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32814053 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDE1A Protein Structure

PDEase_I_N

PDEase_I_N: 3'5'-cyclic nucleotide phosphodiesterase N-terminal (73 - 133)

PDEase_I

PDEase_I: 3'5'-cyclic nucleotide phosphodiesterase (218 - 446)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 535 a.a.
Protein Preferred Names Protein Names

dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A

calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A

  • 61 kDa Cam-PDE

  • calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase

  • phosphodiesterase 1A, calmodulin-dependent

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (5)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-12501A ITI-214 Inhibitor 99.56% Phase 2
HY-112831 Osoresnontrine Inhibitor 99.94% Phase 2
HY-12501 ITI-214 free base Inhibitor 98.0% Phase 2
HY-111167 AN-2898 Inhibitor / Phase 2
HY-103493 TAK-915 Inhibitor 99.57% Phase 1

Pre-clinical Phase

Bioactive Molecules (9)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-136569 DSR-141562 Inhibitor 99.98% Unkown
HY-101490 PDE1-IN-2 Inhibitor 98.0% Unkown
HY-120741 PF-04822163 Inhibitor / Unkown
HY-120195 PF-04677490 Inhibitor / Unkown
HY-120195A PF-04827736 Inhibitor / Unkown
HY-147946 PDE1-IN-4 Inhibitor / Unkown
HY-RS10208 PDE1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10209 Pde1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10210 PDE1A Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PDE1A VGNC VGNC:44348
Mus musculus PDE1A MGD MGI:1201792
Rattus norvegicus PDE1A RGD RGD:68329
Macaca mulatta PDE1A VGNC VGNC:75909
Bos taurus PDE1A VGNC VGNC:32671
Felis catus PDE1A VGNC VGNC:68752
Others PDE1A NCBI