RAD52 - RAD52 homolog, DNA repair protein Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5893

About RAD52

Cytogenetic location: 12p13.33 Genomic coordinates (GRCh38): 12:911,736-991,122 (from NCBI)

This gene has 19 transcripts (splice variants) and 193 orthologues. Ubiquitous expression in fat (RPKM 4.4), skin (RPKM 4.2) and 25 other tissues.

Summary

The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. It was also found to interact with DNA recombination protein RAD51, which suggested its role in RAD51 related DNA recombination and repair. A pseudogene of this gene is present on chromosome 2. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2014]

RAD52 Products (5)

mRNA	Protein	Name
NM_001297419.1	NP_001284348.1	DNA repair protein RAD52 homolog isoform a
NM_001297420.1	NP_001284349.1	DNA repair protein RAD52 homolog isoform b
NM_001297421.2	NP_001284350.1	DNA repair protein RAD52 homolog isoform c
NM_001297422.2	NP_001284351.1	DNA repair protein RAD52 homolog isoform d
NM_134424.4	NP_602296.2	DNA repair protein RAD52 homolog isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables DNA binding	IDA IDA: Inferred from direct assay	19506022	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	10744977	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8702565	GOA
enables single-stranded DNA binding	IMP IMP: Inferred from mutant phenotype	12370410	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
acts upstream of or within DNA double-strand break processing involved in repair via single-strand annealing	IDA IDA: Inferred from direct assay	19506022	GOA
involved in DNA recombination	IMP IMP: Inferred from mutant phenotype	8702565	GOA
acts upstream of or within cellular response to oxidative stress	IDA IDA: Inferred from direct assay	19506022	GOA
acts upstream of or within regulation of nucleotide-excision repair	IDA IDA: Inferred from direct assay	19506022	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in nucleus	IDA IDA: Inferred from direct assay	19506022	GOA
part of protein-DNA complex	IMP IMP: Inferred from mutant phenotype	12370410	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	19506022	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAD52 Protein Structure

Rad52_Rad22

0
100
200
300
400
418 a.a.

Protein Preferred Names	Protein Names
DNA repair protein RAD52 homolog	recombination protein RAD52

RAD52 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	RAD52	P43351	RDM1	Homo sapiens	Q8NG50	Validated Y2H	32296183
Intra	RAD52	P43351	RDM1	Homo sapiens	Q8NG50	Y2H Prey Pooling	32296183
Intra	RAD52	P43351	RDM1	Homo sapiens	Q8NG50	Y2H Array	32296183
Intra	RAD52	P43351	NFYC	Homo sapiens	Q13952-2	Validated Y2H	32296183
Intra	RAD52	P43351	NFYC	Homo sapiens	Q13952-2	Y2H Prey Pooling	32296183
Intra	RAD52	P43351	NFYC	Homo sapiens	Q13952-2	Y2H Array	32296183
Intra	RAD52	P43351	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	RAD52	P43351	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	RAD52	P43351	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	RAD52	P43351	MEOX1	Homo sapiens	P50221	Y2H Prey Pooling	32296183
Intra	RAD52	P43351	MEOX1	Homo sapiens	P50221	Validated Y2H	32296183
Intra	RAD52	P43351	MEOX1	Homo sapiens	P50221	Y2H Array	32296183
Intra	RAD52	P43351	PAX5	Homo sapiens	Q02548	Y2H Prey Pooling	32296183
Intra	RAD52	P43351	PAX5	Homo sapiens	Q02548	Validated Y2H	32296183
Intra	RAD52	P43351	PAX5	Homo sapiens	Q02548	Y2H Array	32296183
Intra	RAD52	P43351	KPNA3	Homo sapiens	O00505	Y2H Array	32296183
Intra	RAD52	P43351	KPNA3	Homo sapiens	O00505	Y2H Prey Pooling	32296183
Intra	RAD52	P43351	WRN	Homo sapiens	Q14191	IF	12750383
Intra	RAD52	P43351	WRN	Homo sapiens	Q14191	Anti Bait CoIP	12750383
Intra	RAD52	P43351	WRN	Homo sapiens	Q14191	CoIP	12750383
Intra	RAD52	P43351	DCP1A	Homo sapiens	Q9NPI6	Y2H Array	32296183
Intra	RAD52	P43351	DCP1A	Homo sapiens	Q9NPI6	Y2H Prey Pooling	32296183
Intra	RAD52	P43351	DCP1A	Homo sapiens	Q9NPI6	Validated Y2H	32296183
Intra	RAD52	P43351	KPNA5	Homo sapiens	O15131	Y2H Prey Pooling	32296183
Intra	RAD52	P43351	KPNA5	Homo sapiens	O15131	Y2H Array	32296183
Intra	RAD52	P43351	RPA3	Homo sapiens	P35244	Anti Tag CoIP	19338310
Intra	RAD52	P43351	RAD52	Homo sapiens	P43351	3D-EM-Tomo	10744977
Intra	RAD52	P43351	RAD52	Homo sapiens	P43351	BN-PAGE	21804533
Intra	RAD52	P43351	RAD52	Homo sapiens	P43351	Y2H	12750383
Intra	RAD52	P43351	RAD52	Homo sapiens	P43351	Validated Y2H	32296183
Intra	RAD52	P43351	RAD52	Homo sapiens	P43351	TEM	10744977
Intra	RAD52	P43351	RAD52	Homo sapiens	P43351	Y2H Prey Pooling	32296183
Intra	RAD52	P43351	RAD52	Homo sapiens	P43351	Y2H Array	32296183
Intra	RAD52	P43351	PLK3	Homo sapiens	Q9H4B4	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

RAD52 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P82971	Rad52 Antibody (YA2716)	WB	Human

Related Diseases

Diseases	Alias
Non-Syndromic X-Linked Intellectual Disability 2	Mrx2
Werner Syndrome	Werner'S Syndrome WRN Adult Progeria Ws Adult Premature Ageing Syndrome Adult Premature Aging Syndrome Werners Syndrome
Short-Rib Thoracic Dysplasia 2 With Or Without Polydactyly	Asphyxiating Thoracic Dystrophy 2 SRTD2 Atd2 Jatd Jeune Asphyxiating Thoracic Dystrophy Jeune Syndrome 2
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Xeroderma Pigmentosum, Variant Type	Xeroderma Pigmentosum XPV Xeroderma Pigmentosum Variant Type Xeroderma Pigmentosum With Normal Dna Repair Rates Photosensitivity With Defective Dna Synthesis Xp De Sanctis-Cacchione Syndrome Desanctis-Cacchione Syndrome Xeroderma Pigmentosa Xerodermic Idiocy Xeroderma Pigmentosum Variant Xp - [Xeroderma Pigmentosum] Atrophoderma Pigmentosum
Idiopathic Peripheral Autonomic Neuropathy
Rothmund-Thomson Syndrome, Type 2	Rothmund-Thomson Syndrome Rts RTS2 Poikiloderma Of Rothmund-Thomson Rothmund-Thomson Syndrome Type 2 Congenital Poikiloderma Poikiloderma Congenitale Poikiloderma Atrophicans And Cataract Poikiloderma Congenitale Of Rothmund-Thomson Poikiloderma Of Rothmund-Thomson Type 2 Rothmund-Thomson Syndrome 2 Erythrokeratodermia Variabilis
Xeroderma Pigmentosum, Complementation Group G	Xeroderma Pigmentosum, Group G Xeroderma Pigmentosum Vii Xp7 XPG Xeroderma Pigmentosum Group G Xp Group G Xp, Group G Xpgc Xeroderma Pigmentosum, Group G/Cockayne Syndrome Xeroderma Pigmentosum, Type 7 Xeroderma Pigmentosum Complementation Group G XP-G Xp-G/Cs Xeroderma Pigmentosum Group G/Cockayne Syndrome
Nijmegen Breakage Syndrome	Berlin Breakage Syndrome NBS Microcephaly, Normal Intelligence And Immunodeficiency Ataxia-Telangiectasia Variant Ataxia-Telangiectasia Variant V1 Seemanova Syndrome Ii Immunodeficiency-Microcephaly-Chromosomal Instability Syndrome Seemanova Syndrome Type 2 At-V1 Microcephaly With Normal Intelligence, Immunodeficiency, And Lymphoreticular Malignancies Nonsyndromal Microcephaly, Autosomal Recessive, With Normal Intelligence Immunodeficiency, Microcephaly, And Chromosomal Instability Microcephaly-Immunodeficiency-Lymphoreticuloma Syndrome Microcephaly Immunodeficiency Lymphoreticuloma Microcephaly With Normal Intelligence Immunodeficiency And Lymphoreticular Malignancies Nonsyndromal Microcephaly Autosomal Recessive With Normal Intelligence Seemanova Syndrome 2 Ataxia-Telangiectasia Variant 1 Seemanova Syndrome At V1 Ataxia-Telangiectasia, Variant 1 Microcephaly-Immunodeficiency-Lymphoid Malignancy Syndrome V-At Ataxia Telangiectasia Variant V1
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Hereditary Breast Ovarian Cancer Syndrome	Hereditary Breast And Ovarian Cancer Syndrome Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer Breast And/Or Ovarian Cancer Breast And Ovarian Cancer Syndrome Hboc Syndrome Hereditary Breast And Ovarian Cancer Brca1- Brca2-Associated Hboc
Cockayne Syndrome B	Cockayne Syndrome Type 2 Cockayne Syndrome, Type B Cockayne Syndrome Type Ii CSB Cockayne Syndrome 2 Cockayne Syndrome Type B Ckn2 Cockayne Syndrome, Type Ii
Aplastic Anemia	Aplastic Anemia, Susceptibility To Anemia Aplastic Idiopathic Aplastic Anemia Secondary Aplastic Anemia Idiopathic Bone Marrow Failure Aplastic Anemia Idiopathic AA Anemia, Aplastic Aplastic Anemia, Idiopathic Erythroid Aplasia Aa - [Aplastic Anaemia] Haematopoietic Aplasia Aleukia Haemorrhagica Anaemia Due To Decreased Red Cell Production Aplasia Bone Marrow Aplastic Bone Marrow Hypoplastic Anaemia Nos Myeloid Bone Marrow Aplasia Pancytopenia Panhaematopenia Hypoproliferative Anaemia Medullary Hypoplasia Red Blood Cells Hypoplastic Anaemia Panmyelophthisis Panhemocytopenia Refractive Hypoproliferative Anaemia Toxic Anaemia Toxic Aplastic Anaemia Aplastic Anaemia Due To Toxic Cause Idiopathic Aplastic Anaemia Nos
Trichothiodystrophy	Ttd Amish Brittle Hair Syndrome Bids Syndrome Brittle Hair-Intellectual Impairment-Decreased Fertility-Short Stature Syndrome Ibids Pibids Trichothiodystrophy Syndromes
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-124691	D-I03	Inhibitor	99.70%	Unkown
HY-110286	6-Hydroxy-DOPA	Inhibitor	98.37%	Unkown
HY-153338	C791-0064		99.15%	Unkown
HY-122583	D-G23	Inhibitor	/	Unkown
HY-RS11610	RAD52 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17558	Rad52 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24016	Rad52 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RAD52	RGD	RGD:1304975
Canis familiaris	RAD52	VGNC	VGNC:45321
Bos taurus	RAD52	VGNC	VGNC:33688
Macaca mulatta	RAD52	VGNC	VGNC:97817
Mus musculus	RAD52	MGD	MGI:101949
Others	RAD52	NCBI