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Art. -Nr.: HY-162449

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GIC-20

GIC-20 is a dual inducer for apoptosis and ferroptosis. GIC-20 exhibits antitumor efficacy against fibrosarcoma.

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CAS. Nr.: 2942242-60-4
Formel: C₃₈H₃₇ClN₄O₅S
Molecular Weight:697.24

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

GIC-20 Chemical Structure

CAS. Nr.: 2942242-60-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

GIC-20 is a dual inducer for apoptosis and ferroptosis. GIC-20 exhibits antitumor efficacy against fibrosarcoma^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HT-1080	IC₅₀	1.6 μM Compound: GIC-20	Cytotoxicity against human HT-1080 cells incubated for 48 hrs by CCK-8 assay Cytotoxicity against human HT-1080 cells incubated for 48 hrs by CCK-8 assay	[PMID: 38593589]

In Vitro

GIC-20 (1 μM, 48 h) inhibits proliferation and migration of HT1080 fibrosarcoma cells, exhibits cytotoxicity with IC₅₀ of 1.6 μM^[1].
GIC-20 (0.5-4 μM, 24 h) induces ferroptosis by inducing intracellular lipid peroxide and ROS accumulation, or by degradation of GPX4^[1].
GIC-20 (0-1 μM, 24 h) inhibits cell viability of drug-resistant MIA-PaCa-2-AMG510R cells, enhances the sensitivity of MIA-PaCa-2-AMG510R cells to AMG510^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

HT1080
Concentration:

0-4 μM
Incubation Time:

24 h
Result:

Inhibited expression of GPX4 and Bcl-2, promoted expression of Bax.

Apoptosis Analysis^[1]

Cell Line:

HT1080
Concentration:

0-4 μM
Incubation Time:

24 h
Result:

Induced apoptosis in a dose-dependent manner.

In Vivo

GIC-20 (20-40 mg/kg, i.p., once daily for 19 days) exhibits antitumor efficacy in HT1080 xenograft BALB/c mice, without significant toxicity in major organs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

HT1080 xenograft BALB/c mice^[1]
Dosage:

20-40 mg/kg
Administration:

i.p., once a day for 19 days
Result:

Inhibited tumor growth, with a TGI of 63% at 40 mg/kg.
Maintained a complete morphology without obvious cellular inflammatory, oedema, or necrosis in major organs.

Chemical Information

CAS. Nr. 2942242-60-4
Molecular Weight 697.24
Formel C₃₈H₃₇ClN₄O₅S
SMILES

O=C1C=C(NCCCCCC(NC2=CC=C(N(C(C(NCCC3=CC=CC=C3)=O)C4=CC=CS4)C(CCl)=O)C=C2)=O)C(C5=CC=CC=C51)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Ma F, et al., ML162 derivatives incorporating a naphthoquinone unit as ferroptosis/apoptosis inducers: Design, synthesis, anti-cancer activity, and drug-resistance reversal evaluation. Eur J Med Chem. 2024 Apr 15;270:116387. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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