KS124
KS124 (compound 3) is a potent ALDH inhibitor. KS124 shows inhibition for ALDH1A1, ALDH1A3, ALDH3A1. KS124 shows antiproliferative activity. KS124 induces apoptosis and ROS production.
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- Formel: C21H12Br2N2O7
- Molecular Weight:564.14
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
KS124 (compound 3) (3 µM; 24, 48 h) induces apoptosis in a time-dependent manner in HCT-116 cells[1].
KS124 (3 µM; 48 h) increases ROS production in HCT-116 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCT-116, SKOV-3, MIA PaCa-2, HEK-293, FHC cells
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Concentration:0-50 µM
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Incubation Time:48 h
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Result:Inhibited cell viability with IC50s of 2.2, 3.8, 2.1, 8.7, 7.1 µM for HCT-116, SKOV-3, MIA PaCa-2, HEK-293, FHC cells, respectively.
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Cell Line:HCT-116 cells
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Concentration:3 µM
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Incubation Time:24 h, 48 h
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Result:Induced apoptosis with the late apoptotic cell populations of 12.30%, 15.45% at 24, 48 h, respectively.
Chemical Information
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Molecular Weight 564.14
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Formel C21H12Br2N2O7
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SMILES
O=C(C1=CC=C([N+]([O-])=O)O1)OCC2=CC=C(CN3C(C(C4=C3C(Br)=CC(Br)=C4)=O)=O)C=C2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
KS124 Related Classifications
HY-159111 Related Classifications
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