Methoxyacetic acid
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Methoxyacetic acid is a metabolite of ethylene glycol monomethyl ether. When the concentration of methoxyacetic acid reaches a certain level, it can inhibit the respiratory function of hepatic mitochondria and testicular mitochondria. Methoxyacetic acid is somewhat toxic.
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- Reinheit: 99.97%
- CAS. Nr.: 625-45-6
- Formel: C3H6O3
- Molecular Weight:90.08
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Speicherung:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Methoxyacetic acid (>5 mM) inhibits the state 3 succinate oxidation rate and the respiratory control ratio in hepatic mitochondria[1].
Methoxyacetic acid (>3 mM) inhibits the ascorbate/TMPD oxidation rate in testicular mitochondria[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Fischer 344 rats (6-8 weeks of age)[2]
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Dosage:30, 100 and 300 mg/kg
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Administration:Oral gavage (i.g.); 5 consecutive days of the first week followed by 3 more consecutive daily doses after a weekend interruption.
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Result:Led to a significant decrease in body weight compared to the control group. It also caused severe degeneration of testicular germinal epithelium, a marked reduction in the size of the thymus with depletion of thymic cortical lymphoid elements, and a reduction in bone marrow cellularity, resulting in lower red blood cell counts, hemoglobin concentration, packed cell volume, and white blood cell counts at dose of 300 mg/kg.
Had some similar but less pronounced effects, such as a significant decrease in the relative thymus weight and slight degenerative changes in testicular germinal epithelium in some rats at dose of 100 mg/kg.
Produced no apparent effects during the course of the study at dose of 30 mg/kg.
Chemical Information
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CAS. Nr. 625-45-6
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Appearance Liquid (Density: 1.174 g/cm3)
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Molecular Weight 90.08
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Formel C3H6O3
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Color Colorless to light yellow
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SMILES
O=C(O)COC
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (1110.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 100 mg/mL (1110.12 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (27.75 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (27.75 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Reinheit & Dokumentation
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Data Sheet (271 KB)
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SDS (779 KB)
- English - EN (779 KB)
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- Italian - IT (779 KB)
- Korean - KR (779 KB)
- Portuguese - PT (779 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 11.1012 mL | 55.5062 mL | 111.0124 mL | 277.5311 mL |
| 5 mM | 2.2202 mL | 11.1012 mL | 22.2025 mL | 55.5062 mL | |
| 10 mM | 1.1101 mL | 5.5506 mL | 11.1012 mL | 27.7531 mL | |
| 15 mM | 0.7401 mL | 3.7004 mL | 7.4008 mL | 18.5021 mL | |
| 20 mM | 0.5551 mL | 2.7753 mL | 5.5506 mL | 13.8766 mL | |
| 25 mM | 0.4440 mL | 2.2202 mL | 4.4405 mL | 11.1012 mL | |
| 30 mM | 0.3700 mL | 1.8502 mL | 3.7004 mL | 9.2510 mL | |
| 40 mM | 0.2775 mL | 1.3877 mL | 2.7753 mL | 6.9383 mL | |
| 50 mM | 0.2220 mL | 1.1101 mL | 2.2202 mL | 5.5506 mL | |
| 60 mM | 0.1850 mL | 0.9251 mL | 1.8502 mL | 4.6255 mL | |
| 80 mM | 0.1388 mL | 0.6938 mL | 1.3877 mL | 3.4691 mL | |
| 100 mM | 0.1110 mL | 0.5551 mL | 1.1101 mL | 2.7753 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Methoxyacetic acid Related Classifications
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