country

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-153713

Copy Link Print Information

MYC-RIBOTAC

1 Cited Publications

Kundenbewertung

Based on 1 publication(s) in Google Scholar

MYC-RIBOTAC is a nucleic acid-targeting degrader (ribonuclease-targeting chimera, RIBOTAC) that targets the MYC internal ribosome entry site (IRES). MYC-RIBOTAC contains a MYC mRNA binding component and a small molecule that recruits and locally activates RNAse L1. MYC-RIBOTAC reduces MYC mRNA and protein expression levels, induces cell apoptosis, and can be used for antitumor research. MYC-RIBOTAC consists of pre-miR-155 binder Anticancer agent 167 (HY-156839), RNA binder NCI-B16 (HY-156215), and Linker Amino-PEG4-alcohol (HY-W008005).

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 98.17%
Formel: C₅₅H₅₈N₁₀O₁₁S
Molecular Weight:1067.17

Speicherung:

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

MYC-RIBOTAC Chemical Structure

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Bioz

Biologische Aktivität

Beschreibung

MYC-RIBOTAC is a nucleic acid-targeting degrader (ribonuclease-targeting chimera, RIBOTAC) that targets the MYC internal ribosome entry site (IRES). MYC-RIBOTAC contains a MYC mRNA binding component and a small molecule that recruits and locally activates RNAse L1. MYC-RIBOTAC reduces MYC mRNA and protein expression levels, induces cell apoptosis, and can be used for antitumor research^[1]. MYC-RIBOTAC consists of pre-miR-155 binder Anticancer agent 167 (HY-156839), RNA binder NCI-B16 (HY-156215), and Linker Amino-PEG4-alcohol (HY-W008005).

In Vitro

MYC-RIBOTAC (0-10 μM; 48 hours) decreases the abundance of MYC mRNA and protein levels in HeLa cells in a dose-dependent and RNase L dependent manner^[1].
MYC-RIBOTAC (0-10 μM; 48 hours) has antiproliferative and induce-apoptotic effects in HeLa cells and Namalwa cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

HeLa cells and Namalwa cells
Concentration:

0-10 μM
Incubation Time:

48 hours
Result:

Had antiproliferative and induce-apoptotic effects in in HeLa cells.
Induced cell cycle arrest and provoked apoptosis and reduced colony formation by about 50% in Namalwa cells.

Western Blot Analysis^[1]

Cell Line:

HeLa cells
Concentration:

0-10 μM
Incubation Time:

48 hours
Result:

Decreased the abundance of MYC mRNA in HeLa cells in a dose-dependent and RNase L dependent manner, up to around 50% at a 10 μM dose with a concomitant reduction in MYC protein levels.

Chemical Information

Appearance Solid
Molecular Weight 1067.17
Formel C₅₅H₅₈N₁₀O₁₁S
Color Light yellow to yellow
SMILES

O=C(NC1=CC(NC(NC2=CC=C(C3=NCCN3)C=C2)=O)=CC(C(NCCOCCOCCOCCOC4=C(O)C=C(/C=C5SC(NC6=CC=CC=C6)=C(C(OCC)=O)C\5=O)C=C4)=O)=C1)NC7=CC=C(C8=NCCN8)C=C7
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (1)

All

Sort by:

Journal Impact Factor

bioRxiv

2026 Feb 2.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (93.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

0.9371 mL

4.6853 mL

9.3706 mL

5 mM

0.1874 mL

0.9371 mL

1.8741 mL

10 mM

0.0937 mL

0.4685 mL

0.9371 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Tong Y, et.al. Programming inactive RNA-binding small molecules into bioactive degraders. Nature. 2023 Jun;618(7963):169-179. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	0.9371 mL	4.6853 mL	9.3706 mL	23.4264 mL
	5 mM	0.1874 mL	0.9371 mL	1.8741 mL	4.6853 mL
	10 mM	0.0937 mL	0.4685 mL	0.9371 mL	2.3426 mL
	15 mM	0.0625 mL	0.3124 mL	0.6247 mL	1.5618 mL
	20 mM	0.0469 mL	0.2343 mL	0.4685 mL	1.1713 mL
	25 mM	0.0375 mL	0.1874 mL	0.3748 mL	0.9371 mL
	30 mM	0.0312 mL	0.1562 mL	0.3124 mL	0.7809 mL
	40 mM	0.0234 mL	0.1171 mL	0.2343 mL	0.5857 mL
	50 mM	0.0187 mL	0.0937 mL	0.1874 mL	0.4685 mL
	60 mM	0.0156 mL	0.0781 mL	0.1562 mL	0.3904 mL
	80 mM	0.0117 mL	0.0586 mL	0.1171 mL	0.2928 mL

Keywords

MYC-RIBOTAC

1 Cited Publications

100 mg Angebot einholen

Subscribe to the

MedChemExpress

Newsletter

100 mg

Angebot einholen Auf Lager

Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

MYC-RIBOTAC

Publications Citing Use of MedChemExpress (MCE) MYC-RIBOTAC

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

MYC-RIBOTAC Related Classifications

Art. -Nr.: HY-153713