Art. -Nr.: HY-119176

Oxyfluorfen

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Oxyfluorfen is a pre- and post-emergence diphenyl ether herbicide to control annual broad-leaved and grass weeds. Oxyfluorfen is a protoporphyrinogen oxidase inhibitor and inhibits photosynthesis by blocking chlorophyll synthesis. Oxyfluorfen can inhibit cell growth. Oxyfluorfen induces DNA damage and exhibits toxicity toward aquatic organisms such as Paramisgurnus dabryanus. Oxyfluorfen has genome-level deleterious effects on fish that can lead to stunted skeletal growth. Oxyfluorfen induces transverse limb deficiency or craniosynostosis.

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Reinheit: 99.69%
CAS. Nr.: 42874-03-3
Formel: C₁₅H₁₁ClF₃NO₄
Molecular Weight:361.70

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Oxyfluorfen Chemical Structure

CAS. Nr.: 42874-03-3

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Oxyfluorfen (10 nM, 12 d) strongly inhibits the growth of normal soybean cells but not resistant cells^[2].
Oxyfluorfen (0-100 μM) inhibits the total extractable Protox activity in normal cells but not resistant cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Oxyfluorfen (0.3-0.6 mg/L, exposure for 21 d) leads to a significant increase in CAT activity except for 0.6 mg/L at 21 days as well as an increase in GR activity, whilst it significantly inhibits SOD activity at all days in fish^[3].
Oxyfluorfen (0-800 ppm, in the diet, 7 or 28 d) exhibits liver toxicity in mice^[4].
Oxyfluorfen (40-1600 ppm, in the diet, 3 or 10 d) results in a dose-responsive induction in PPARα genes (Cyp4a10, Acox1, Cte-1 and Pmp-70) in mice model^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male CD-1 mice (up to 12 weeks) with ad libitum access to feed^[4]
Dosage:

0, 40, 200 and 800 ppm
Administration:

Added to diet for 7 or 28 days
Result:

Resulted in significant increases in absolute and relative lever weights with 800 ppm.
Increased the liver weights with no statistical significance at 200 ppm.
Increased peroxisomal ACO activity 1.5- and 5-fold above control levels after 28 days with 200 and 800 ppm, respectively.
Increased cell proliferation after 28 days with 800 ppm.
Led to hypertrophy, vacuolization, single-cell necrosis and additional liver changes in mice given 800 ppm for 28 days.

Chemical Information

CAS. Nr. 42874-03-3
Appearance Solid
Molecular Weight 361.70
Formel C₁₅H₁₁ClF₃NO₄
Color Off-white to light yellow
SMILES

FC(C1=CC=C(OC2=CC=C([N+]([O-])=O)C(OCC)=C2)C(Cl)=C1)(F)F
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (276.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.7647 mL

13.8236 mL

27.6472 mL

5 mM

0.5529 mL

2.7647 mL

5.5294 mL

10 mM

0.2765 mL

1.3824 mL

2.7647 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (6.91 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (458 KB)
- English - EN (458 KB)
- Français - FR (458 KB)
- Deutsch - DE (458 KB)
- Norwegian - NO (458 KB)
- Español - ES (458 KB)
- Swedish - SV (458 KB)
- Italian - IT (458 KB)
- Korean - KR (458 KB)
- Portuguese - PT (458 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Chi Wu, et al. Sorption, Degradation and Bioavailability of Oxyfluorfen in Biochar-Amended Soils. Sci Total Environ. 2019 Mar 25;658:87-94. [Content Brief]

[2]. E Warabi, et al. Resistance of a Soybean Cell Line to Oxyfluorfen by Overproduction of Mitochondrial Protoporphyrinogen Oxidase. Pest Manag Sci. 2001 Aug;57(8):743-8. [Content Brief]

[3]. F. Peixoto, et al., Toxicological effects of oxyfluorfen on oxidative stress enzymes in tilapia Oreochromis niloticus, Pesticide Biochemistry and Physiology, Volume 85, Issue 2, 2006, Pages 91-96, ISSN 0048-3575.

[4]. Stagg, N. J., et al., (2012). Assessment of possible carcinogenicity of oxyfluorfen to humans using mode of action analysis of rodent liver effects. Toxicological sciences: an official journal of the Society of Toxicology, 128(2), 334–345. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.7647 mL	13.8236 mL	27.6472 mL	69.1181 mL
	5 mM	0.5529 mL	2.7647 mL	5.5294 mL	13.8236 mL
	10 mM	0.2765 mL	1.3824 mL	2.7647 mL	6.9118 mL
	15 mM	0.1843 mL	0.9216 mL	1.8431 mL	4.6079 mL
	20 mM	0.1382 mL	0.6912 mL	1.3824 mL	3.4559 mL
	25 mM	0.1106 mL	0.5529 mL	1.1059 mL	2.7647 mL
	30 mM	0.0922 mL	0.4608 mL	0.9216 mL	2.3039 mL
	40 mM	0.0691 mL	0.3456 mL	0.6912 mL	1.7280 mL
	50 mM	0.0553 mL	0.2765 mL	0.5529 mL	1.3824 mL
	60 mM	0.0461 mL	0.2304 mL	0.4608 mL	1.1520 mL
	80 mM	0.0346 mL	0.1728 mL	0.3456 mL	0.8640 mL
	100 mM	0.0276 mL	0.1382 mL	0.2765 mL	0.6912 mL

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Oxyfluorfen

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Metabolism/Protease Compound Library

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Oxyfluorfen

Human Metabolite Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Pesticide Compound Library

Protein Kinase Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Environmental Pollutant Compound Library

Metabolism/Protease Compound Library

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Oxyfluorfen Related Classifications

HY-119176 Related Classifications