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Art. -Nr.: HY-155398

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PRO-HD3

PRO-HD3 is a HDAC6 PROTAC degrader. PRO-HD3 exerts antiproliferative activity in leukemia cells. PRO-HD3 can be used for leukemia research.

(Pink: HDAC6 ligand (HY-175627); Blue: Cereblon ligand (HY-41547); Black: linker (HY-W015659)).

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 3126555-94-7
Formel: C₄₀H₄₃N₅O₅S
Molecular Weight:705.86

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

PRO-HD3 Chemical Structure

CAS. Nr.: 3126555-94-7

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

PRO-HD3 is a HDAC6 PROTAC degrader. PRO-HD3 exerts antiproliferative activity in leukemia cells. PRO-HD3 can be used for leukemia research^[1].
(Pink: HDAC6 ligand (HY-175627); Blue: Cereblon ligand (HY-41547); Black: linker (HY-W015659)).

In Vitro

PRO-HD3 (500 nM-5 μM; 24 h) nearly completely degrades HDAC6 in A549 cells at a concentration of 5 μM after 24 h of incubation^[1].
PRO-HD3 (48 h) inhibits Jurkat cell proliferation with an IC₅₀ of 3.80 μM after 48 h of incubation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

adenocarcinomic human alveolar basal epithelial A549 cells
Concentration:

500 nM, 1 μM, 5 μM
Incubation Time:

24 h
Result:

Nearly completely depleted HDAC6 protein at 5 μM.
Partially degraded HDAC6 protein at lower concentrations.

Chemical Information

CAS. Nr. 3126555-94-7
Molecular Weight 705.86
Formel C₄₀H₄₃N₅O₅S
SMILES

S=C1N(CC2=CC=C(C3=CC=C(CNCCCCCCCCNC4=CC=CC(C(N5C6CCC(NC6=O)=O)=O)=C4C5=O)C=C3)C=C2)C=CC=C1O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Jia Q, et al. Cell-Specific Degradation of Histone Deacetylase Using Warhead-Caged Proteolysis Targeting Chimeras. Analytical chemistry. 2023 Nov 14;95(45):16474-16480. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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