Quinovic acid
Based on 1 Customer Validation
Quinovic acid is triterpene. Quinovic acid can ameliorate the Amyloid-β burden, p53 expression and cholesterol accumulation by deterring the oxidative stress through upregulating the Nrf2/HO-1 pathway. Quinovic acid can induce cancer cells apoptosis by upregulating death receptor 5 (DR5). Quinovic acid can be used for the researches of cancer, inflammation, metabolic and neurological disease, such as lung cancer and Alzheimer’s disease (AD).
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 96.0%
- CAS. Nr.: 465-74-7
- Formel: C30H46O5
- Molecular Weight:486.68
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Speicherung:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Quinovic acid (5-115 μM, 24 h) shows low cytotoxicity and alleviates oligomeric Aβ (AβO)-induced cell death in SH-SY5Y cells[1].
Quinovic acid (85 μM, 24 h) downregulates AβO-induced expressions of p53 and 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) in SH-SY5Y cells[1].
Quinovic acid (QA) (5-40 μM, 24-72 h) inhibits the proliferation and viability of A549, H1299, MCF-7 and MDA-MB-231 cells[2].
Quinovic acid (QA) (25-35 μM, 24 h) induces apoptosis in MDA-MB-231 and A549 cells[2].
Quinovic acid (25 μM, 4-24 h) upregulates the mRNA and protein levels of death receptor 5 (DR5) in A549, MCF-7, and MDA-MB-231 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231 and A549 cells
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Concentration:25, 30 and 35 μM
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Incubation Time:24 h
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Result:Reduced procaspase 3 and 8 levels.
Increased cleaved PARP levels.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J mice treated with Aβ(1-42)[1]
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Dosage:50 mg/kg
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Administration:Intraperitoneally injection, every other day for 3 weeks
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Result:Reduced Aβ oligomers, monomers, and BACE1 expression in cortex/hippocampus and decreased Aβ burden.
Downregulated p53 and HMGCR expressions and reduced total and free cholesterol levels.
Activated the Nrf2/HO-1 pathway, reduced ROS levels and restored GSH/GSSG ratio.
Downregulated GFAP, Iba-1, p-NF-κB, and IL-1β.
Downregulated Bax, cytochrome c, cleaved caspase-3; upregulates Bcl-2 and upregulated PSD-95 and synaptophysin.
Enhanced cognitive ability.
Chemical Information
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CAS. Nr. 465-74-7
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Appearance Solid
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Molecular Weight 486.68
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Formel C30H46O5
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Color White to off-white
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SMILES
OC([C@@]12C([C@@]3([H])[C@@](CC2)(CC[C@H]([C@@H]3C)C)C(O)=O)=CC[C@@]4([H])[C@]1(CC[C@]5([H])[C@@]4(CC[C@@H](C5(C)C)O)C)C)=O
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Reinheit & Dokumentation
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Saeed K, et al. Quinovic Acid Impedes Cholesterol Dyshomeostasis, Oxidative Stress, and Neurodegeneration in an Amyloid-β-Induced Mouse Model. Oxid Med Cell Longev. 2020 Nov 20;2020:9523758. [Content Brief]
[2]. Khayam AU, et al. Quinovic acid purified from medicinal plant Fagonia indica mediates anticancer effects via death receptor 5. Mol Cell Biochem. 2020 Nov;474(1-2):159-169. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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