RFI-641
RFI-641 is a selective inhibitor of the respiratory syncytial virus (RSV), with an IC50 of 50 nM. RFI-641 inhibit binding and fusion of enveloped virus via interaction with the viral fusion protein.
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- CAS. Nr.: 197366-24-8
- Formel: C58H60N24Na2O22S6
- Molecular Weight:1683.61
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HFF | IC50 |
0.05 μM
Compound: 3 (RF-1461)
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Inhibitory concentration against human respiratory syncytial virus strain A2 in human foreskin fibroblasts
Inhibitory concentration against human respiratory syncytial virus strain A2 in human foreskin fibroblasts
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[PMID: 15603966] |
| HFF | IC50 |
2.55 μM
Compound: 3 (RF-1461)
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Inhibitory concentration against human cytomegalovirus strain Ad169 in human foreskin fibroblasts
Inhibitory concentration against human cytomegalovirus strain Ad169 in human foreskin fibroblasts
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[PMID: 15603966] |
| Vero | IC50 |
7.72 μM
Compound: 3 (RF-1461)
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Inhibitory concentration against herpes simplex 1 strain Patton in vero cells
Inhibitory concentration against herpes simplex 1 strain Patton in vero cells
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[PMID: 15603966] |
Chemical Information
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CAS. Nr. 197366-24-8
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Molecular Weight 1683.61
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Formel C58H60N24Na2O22S6
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SMILES
O=C(CN(S(=O)(C1=CC(NC2=NC(NC3=CC(S(=O)(O[Na])=O)=C(C4=CC=C(NC5=NC(NC6=CC=CC(S(=O)(N(CC(N)=O)CC(N)=O)=O)=C6)=NC(NC7=CC=CC(S(=O)(N(CC(N)=O)CC(N)=O)=O)=C7)=N5)C=C4S(=O)(O[Na])=O)C=C3)=NC(NC8=CC=CC(S(=O)(N(CC(N)=O)CC(N)=O)=O)=C8)=N2)=CC=C1)=O)CC(N)=O)N
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Reinheit & Dokumentation
Verweise
[1]. Nikitenko AA, et, al. The discovery of RFI-641 as a potent and selective inhibitor of the respiratory syncytial virus. Bioorg Med Chem Lett. 2001 Apr 23;11(8):1041-4. [Content Brief]
[2]. Razinkov V, et, al. RFI-641 inhibits entry of respiratory syncytial virus via interactions with fusion protein. Chem Biol. 2001 Jul;8(7):645-59. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
RFI-641 Related Classifications
HY-19874 Related Classifications
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